Two-generation diet-induced obesity model producing mice with increased amount of body fat in early adulthood

Title:

Two-generation diet-induced obesity model producing mice with increased amount of body fat in early adulthood

Creator:

Kubandová, J., Dušan Fabián, Burkuš, J., Štefan Čikoš, Soňa Czikková, Mozeš, Š., Šefčíková, Z., and Juraj Koppel

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:48bd5e7e-3276-4db4-a72e-aef2c856e4f4
uuid:48bd5e7e-3276-4db4-a72e-aef2c856e4f4

Subject:

Fyziologie člověka a srovnávací fyziologie, obezita, obesity, diet-induced obesity, fat deposits, body weight, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of our study was to develop a model producing obese mice in early adulthood (4-6 weeks) based on their over-nutrition during fetal and early postnatal development. The fertilized dams of the parental generation were fed the standard diet supplemented with high-energy nutritional product Ensure Plus during gestation and lactation. De livered weanlings were then fed with standard or supplemented diet and assessed for body fat deposits using EchoMRI at the ti me of early and late adulthood. Maternal over-feeding during th e period before weaning had the most significant effect on obesity development in the filial generation. In weanlings, signific antly higher body fat deposits and average body weight were recorded. Later, further significant increase in percentage of body fat in both male and female mice was observed. Withdrawal of the Ensure Plus supplement caused a decrease in the percentage of body fat in part of the filial generation. In offspring fed the standard diet, higher fat deposits persisted till the time of late adulthood. We conclude that this diet-induced obesity model might be used in exploration of the effects of elevated body fat on physiological functions of various organ systems during juvenile and early adulthood periods of life of a human being., J. Kubandová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:1

Harvested from:

CDK

Metadata only:

false