Effects of Hyperoxia and Allergic Airway Inflammation on Cough Reflex Intensity in Guinea Pigs

Title:

Effects of Hyperoxia and Allergic Airway Inflammation on Cough Reflex Intensity in Guinea Pigs

Creator:

Mariana Brozmanová, Ján Hanáček, Miloš Tatár, Anna Strapková, and Peter Szépe

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4a1e426e-7cfa-4d08-a7a8-7f96b2dc68fd
uuid:4a1e426e-7cfa-4d08-a7a8-7f96b2dc68fd
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Hyperoxia, Allergic inflammation, Ovalbumin, Citric acid cough, Mechanically induced cough, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Toxic influence of high oxygen concentration on pulmonary function and structures has been known for many years. However, the influence of high oxygen concentration breathing on defensive respiratory reflexes is still not clear. In our previous experiments, we found an inhibitory effect of 100 % oxygen breathing on cough reflex intensity in healthy guinea pigs. The present study was designed to detect the effects of hyperoxia on cough reflex in guinea pigs with allergic airway inflammation. In the first phase of our experiment, the animals were sensitized with ovalbumin. Thirty-two sensitized animals were used in two separate experiments according to oxygen concentration breathing: 100 % or 50 % oxygen for 60 h continuously. In each experiment, one group of animals was exposed to hyperoxia, another to ambient air. The cough reflex was induced both by aerosol of citric acid before sensitization, then in sensitized animals at 24 h and 60 h of exposition to oxygen/air in awake animals, and by mechanical stimulation of airway mucosa in anesthetized animals just after the end of the experiment. In contrast to 50 % oxygen, 100 % oxygen breathing leads to significant decrease in chemically induced cough in guinea pigs with allergic inflammation. No significant changes were present in cough induced by mechanical stimulation of airways., M. Brozmanová, J. Hanáček, M. Tatár, A. Strapková, P. Szépe., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:5

Harvested from:

CDK

Metadata only:

false