Effect of white wine consumption on oxidative stress markers and homocysteine levels

Title:

Effect of white wine consumption on oxidative stress markers and homocysteine levels

Creator:

Daniel Rajdl, Jaroslav Racek, Ladislav Trefil, and Konrad Siala

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4a903713-0b32-42a5-9209-028947ad197d
uuid:4a903713-0b32-42a5-9209-028947ad197d
issn:0862-8408

Subject:

Patologie. Klinická medicína, klinické lékařství, víno, oxidační stres, homocystein, clinical medicine, wine, oxidative stress, homocysteine, bílé víno, white wine, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of this study was to assess the influence of regular daily consumption of white wine on oxidative stress and cardiovascular risk markers. Forty-two healthy male volunteers consumed 375 ml of white wine daily. Each participant provided three venous blood samples (before wine consumption, following the wine consumption period and again a month later). Levels of superoxide dismutase, glutathione peroxidase, reduced glutathione, total antioxidant capacity, total cholesterol, HDL-cholesterol, apolipoprotein A I, apolipoprotein B, triglycerides, paraoxonase 1, C-reactive protein, homocysteine, thiobarbituric acid reactive substances (TBARS) and advanced oxidation protein products (AOPP) were measured. Immediately following the month of white wine consumption there was a significant increase in HDL-cholesterol (p<0.0001), paraoxonase 1 (p<0.001), glutathione peroxidase (p<0.001) and reduced glutathione (p<0.01) levels, a decrease in superoxide dismutase activities (p<0.0001), and a decrease in oxidation protein products (p<0.001) and TBARS (p<0.05) concentrations. However, there was also a clear increase in homocysteine (p<0.0001) after a month of white wine consumption. The results of our non-placebo controlled trial suggest that regular daily white wine consumption is associated not only with both antioxidative and antiatherogenic effects but also with a potentially proatherogenic increase of homocysteine concentrations. and D. Rajdl, J. Racek, L. Trefil, K. Siala.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:2

Harvested from:

CDK

Metadata only:

false