Influence of phenytoin and valproate on thalamocortical evoked potentials and their paired-pulse potentiation

Title:

Influence of phenytoin and valproate on thalamocortical evoked potentials and their paired-pulse potentiation

Creator:

Mareš, P., Pohl, M., and Koryntová, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6d6cb4fd-3d02-455a-80dc-b939f577a114
uuid:6d6cb4fd-3d02-455a-80dc-b939f577a114

Subject:

thalamocortical responses, potentiation, rat, phenytoin, and valproate

Type:

article, model:article, and TEXT

Description:

The action of phenytoin and valproate on thalamocortical responses was studied in adult rats. Single responses were not influenced by either drug. Paired-pulse potentiation of the initial components (first positive and first negative) observed with intervals from 50 to 200 ms under control conditions was abolished by phenytoin (60 mg/kg i.p.) but only moderately influenced by valproate (400 mg/kg i.p.). Paired-pulse potentiation of thalamocortical phenomena cannot be put into connection with the generation of the spike-and-wave rhythm.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:6

Harvested from:

CDK

Metadata only:

false