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1. Influence of phenytoin and valproate on thalamocortical evoked potentials and their paired-pulse potentiation

Creator:
Mareš, P., Pohl, M., and Koryntová, H.
Type:
article, model:article, and TEXT
Subject:
thalamocortical responses, potentiation, rat, phenytoin, and valproate
Language:
English
Description:
The action of phenytoin and valproate on thalamocortical responses was studied in adult rats. Single responses were not influenced by either drug. Paired-pulse potentiation of the initial components (first positive and first negative) observed with intervals from 50 to 200 ms under control conditions was abolished by phenytoin (60 mg/kg i.p.) but only moderately influenced by valproate (400 mg/kg i.p.). Paired-pulse potentiation of thalamocortical phenomena cannot be put into connection with the generation of the spike-and-wave rhythm.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Is the site of action of ethosuximide in the hindbrain ?

Creator:
Mareš, P., Pohl, M., Kubová, H., and Želízko, M.
Type:
article, model:article, and TEXT
Subject:
pentylenetetrazol, ethosuximide, valproate, clonazepam, epileptic EEG activity, and brainstem transection
Language:
English
Description:
The action of ethosuximide, valproate and clonazepam against pentylenetetrazol-induced epileptic EEG phenomena was studied in acute experiments in rats with intercollicular brainstem transection. Ethosuximide lost its action against both rhythmic metrazol activity (model of human absences) and EEG seizures. On the contrary, the action of valproate and clonazepam in cerveau isolé rats was the same as in intact animals. The site of anticonvulsant action of ethosuximide may be localized in hindbrain structures, whereas the actions of both valproate and clonazepam may be demonstrated even if hindbrain structures had been eliminated.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public