Metabolic effects of a hydrophobic alginate derivative and tetrahydrolipstatin in rats fed a diet supplemented with palm fat and cholesterol

Title:

Metabolic effects of a hydrophobic alginate derivative and tetrahydrolipstatin in rats fed a diet supplemented with palm fat and cholesterol

Creator:

Marounek, Milan, Volek, Z., Taubner, T., and Czauderna, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6ed14966-c43d-44de-bad2-f693354480d5
uuid:6ed14966-c43d-44de-bad2-f693354480d5

Subject:

amidated alginate, tetrahydrolipstatin, cholesterol, rats, serum, and liver

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

The effects of octadecylamide of alginic acid (amidated alginate) and tetrahydrolipstatin on serum and hepatic cholesterol, and the faecal output of fat and sterols, were investigated in rats. Amidated alginate is a sorbent of lipids, tetrahydrolipstatin is an inhibitor of pancreatic lipase. Rats were fed diets containing cholesterol and palm fat at 10 and 70 g/kg, respectively. Palm fat was provided by coconut meal. Amidated alginate at 40 g/kg diet significantly decreased serum total cholesterol, low-density lipoprotein and hepatic cholesterol, and hepatic lipids and increased the faecal output of fat and coprostanol. Tetrahydrolipstatin at 300 mg/kg diet significantly decreased low-density lipoprotein cholesterol and hepatic lipids and increased the faecal output of fat. The intake of feed was not significantly influenced; however, the weight gains in rats fed amidated alginate were lower than in rats of the control group. Both amidated alginate and tetrahydrolipstatin modified the fatty acid profile in excreta lipids. Concentrations of saturated fatty acids were decreased and those of unsaturated fatty acids increased. Despite different modes of action, amidated alginate and tetrahydrolipstatin were equally efficient in removing the dietary fat from the body.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

143-149

Source:

Folia biologica | 2021 Volume:67 | Number:4

Harvested from:

CDK

Metadata only:

false