Yeast as a Model Organism to Study Transport and Homeostasis of Alkali Metal Cations

Title:

Yeast as a Model Organism to Study Transport and Homeostasis of Alkali Metal Cations

Creator:

Sychrová, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7015442e-57e6-49f1-8a3f-01903d5cfd96
uuid:7015442e-57e6-49f1-8a3f-01903d5cfd96

Subject:

Alkali metal cations, Na+/H+ antiporter, Osmotolernce, Plasma membrane, and Yeast

Type:

article, model:article, and TEXT

Description:

To maintain an optimum cytoplasmic K+/Na+ ratio, cells employ three distinct strategies: 1) strict discrimination among alkali metal cations at the level of influx, 2) efficient efflux of toxic cations from cells, and 3) selective sequestration ofcations in organelles. Cation efflux and influx are mediated in cells by systems with different substrate specificities and diverse mechanisms, e.g. ATPases, symporters, antiporters, and channels. Simple eukaryotic yeast Saccharomyces cerevisiae cells proved to be an excellent model for studying the transport properties and physiological function of alkali-metal-cation transporters, and the existence of mutant strains lacking their own transport systems provided an efficient tool for a molecular study of alkali-metal-cation tr ansporters from higher eukaryotes upon their expression in yeast cells.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false