Permanent depression of plasma cGMP during long-term space flight

Title:

Permanent depression of plasma cGMP during long-term space flight

Creator:

Rössler, A., Noskov, V., László, Z., Polyakow, V. V., and Helmut Hinghofer-Szalkay

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:71ce4373-d316-4534-b7e4-82025c207736
uuid:71ce4373-d316-4534-b7e4-82025c207736
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, Long-duration space flight, head-down tilt, cyclic guanosine monophosphate, atrial natriuretic peptide, bed rest, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmonauts preflight (supine), inflight, and postflight (supine) and in five other subjects before, at the end, and 4 days after a 5-day head-down tilt (-6°) bed rest. In cosmonaut 1 (10 days in space), plasma cGMP fell from preflight 4.3 to 1.4 nM on flight day 6, and was 3.0 nM on the fourth day after landing. In cosmonaut 2 (438 days in space), it fell from preflight 4.9 to 0.5 nM on on flight day 3, and stayed <0.1 nM with 5, 9, and 14 months in space, as well as on the fourth day after landing. Three months after the flight his plasma cGMP was back to normal (6.3 nM). Cosmonaut 2 also displayed relatively low inflight ANP values but returned to preflight level immediately after landing. In a ground-based simulation on five other persons, supine plasma cGMP was reduced by an average of 30 % within 5 days of 6° head-down tilt bed rest. The data consistently demonstrate lowered plasma cGMP with real and simulated weightlessness, and a complete disappearance of cGMP from plasma during, and shortly after long-duration space flight., A. Rössler, V. Noskov, Z. László, V.V. Polyakow, H. G. Hinghofer-Szalkay., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:1

Harvested from:

CDK

Metadata only:

false