Prenatal methamphetamine exposure induces long-lasting alterations in memory and development of NMDA receptors in the hippocampus

Title:

Prenatal methamphetamine exposure induces long-lasting alterations in memory and development of NMDA receptors in the hippocampus

Creator:

Romana Šlamberová, Monika Vrajová, Barbora Schutová, Mertlová, M., Macúchová, E., Kateryna Nohejlová, Hrubá, L., Puskarčíková, J., Věra Valešová, and Anna Yamamotová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:87f48ec1-7d51-453f-aa87-8f7be28bfcea
uuid:87f48ec1-7d51-453f-aa87-8f7be28bfcea
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, pervitin, paměť, methamphetamine, memory, hippocampus, NMDA receptors, NR1, NR2A, NR2B, PSD-95, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Since close relationship was shown between drug addiction and memory formation, the aim of the present study was to investigate the effects of interaction between prenatal methamphetamine (MA) exposure and MA treatment in adulthood on spatial and non-spatial memory and on the structure of the N-methyl-D-aspartate (NMDA) receptors in the hippocampus. Adult male rats prenatally exposed to MA (5 mg/kg) or saline were tested in adulthood. Non-spatial memory was examined in the Object Recognition Test (ORT) and spatial memory in the Object Location Test (OLT) and in the Memory Retention Test (MRT) conducted in the Morris Water Maze (MWM), respectively. Based on the type of the memory test animals were injected either acutely (ORT, OLT) or long-term (MWM) with MA (1 mg/kg). After each testing, animals were sacrificed and brains were removed. The hippocampus was then examined in Western Blot analysis for occurrence of different NMDA receptors’ subtypes. Our results demonstrated that prenatal MA exposure affects the development of the NMDA receptors in the hippocampus that might correspond with improvement of spatial memory tested in adulthood in the MWM. On the other hand, the effect of prenatal MA exposure on nonspatial memory examined in the ORT was the opposite. In addition, we showed that the effect of MA administration in adulthood on NMDA receptors is influenced by prenatal MA exposure, which seems to correlate with the spatial memory examined in the OLT., R. Šlamberová, M. Vrajová, B. Schutová, M. Mertlová, E. Macúchová, K. Nohejlová, L. Hrubá, J. Puskarčíková, V. bubeníková-Valešová, A. Yamamotová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false