Opposite effects of nitric oxide on identified inhibitory and excitatory cholinergic synapses of aplysia californica

Title:

Opposite effects of nitric oxide on identified inhibitory and excitatory cholinergic synapses of aplysia californica

Creator:

Mothet, J. P., Fossier, P., Schirar, A., Tauc, L., and Baux, G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8b450b5e-0eb8-478a-a4af-9afe63c7b7ca
uuid:8b450b5e-0eb8-478a-a4af-9afe63c7b7ca

Subject:

nitric oxide, guanylate cyclase, synaptic transmission, and voltage-gated presynaptic currents

Type:

article, model:article, and TEXT

Description:

The effects of nitric oxide on evoked acetylcholine (ACh) release were studied at two identified cholinergic neuro-neuronal synapses of the nervous system of the mollusc Aplysia californica. The NO- donor, 3-morpholinosydnonimine (SIN-1), decreased the amplitude of evoked inhibitory postsynaptic currents (buccal ganglion) and potentiated that of evoked excitatory postsynaptic currents (abdominal ganglion). SIN-1 acted by modulating the number of ACh quanta released. 8Br-cGMP mimicked the effects of NO on ACh release in both types of synapses thus pointing to the involvement of a NO- sensitive guanylate cyclase. Presynaptic voltage-dependent Ca2+ and K+ (Ia and late outward rectifier) currents were not modified by SIN-1 suggesting another final target for NO/cGMP. The labelling of a NO-synthase by immunostaining in several neurones as well as the modulation of ACh release by L-arginine indicate that an endogenous NO-synthase is involved in the modulation of synaptic efficacy in both buccal and abdominal ganglia.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:3

Harvested from:

CDK

Metadata only:

false