Influence of phénobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis

Title:

Influence of phénobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis

Creator:

Staňková, L. and Mareš, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a0fc9c14-bb9b-40a4-bf3c-bbe0ca53555a
uuid:a0fc9c14-bb9b-40a4-bf3c-bbe0ca53555a

Subject:

EEG, pentylenetetrazol, phénobarbital, ontogenesis, and rat

Type:

article, model:article, and TEXT

Description:

Effect of phénobarbital (PhB, 20 and/or 40 mg/kg) on epileptic ECoG phenomena induced by metrazol was studied in acute experiments in rats aged 7, 12, 18, 25 and 90 days. Fractionated administration of metrazol (20 mg/kg i.p. each 300 s) was used to quantify the effects of PhB. First signs of metrazol action (sharp elements and/or rhythmic metrazol activity) were not reliably influenced by PhB. On the contrary, the latency of the first EEG seizures as well as of the first generalized EEG seizures was prolonged and thus a dose necessary for their elicitation was increased in all age groups. These differences reached statistical significance in 12-, 18- and 25-day-old rats. A lack of effect of PhB against the rhythmic metrazol activity supports the adequacy of this activity as a model of human absences. Differences between the development of antiepileptic and hypnotic effects of PhB (described earlier) suggest two different mechanisms of action.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:2

Harvested from:

CDK

Metadata only:

false