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1. Effect of tubocurarine on the central generator of embryonic spontaneous motility

Creator:
Sedláček, J.
Type:
article, model:article, and TEXT
Subject:
chick embryo, spontaneous motility, d-tubocurarine, phénobarbital, and spinal cord
Language:
English
Description:
The continuous administration of d-tubocurarine (6.5 ± 0.4 mg/kg e.w./24 h) to chick embryos from the 4th to the 12th day of incubation had a positive effect on defects produced in the development of spontaneous motility either by decentralization of the spinal cord or by chemical phénobarbital depression, or by a combination of both experimental factors. In normal embryos, d-tubocurarine had no effect on the development of spontaneous motility.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Influence of phénobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis

Creator:
Staňková, L. and Mareš, P.
Type:
article, model:article, and TEXT
Subject:
EEG, pentylenetetrazol, phénobarbital, ontogenesis, and rat
Language:
English
Description:
Effect of phénobarbital (PhB, 20 and/or 40 mg/kg) on epileptic ECoG phenomena induced by metrazol was studied in acute experiments in rats aged 7, 12, 18, 25 and 90 days. Fractionated administration of metrazol (20 mg/kg i.p. each 300 s) was used to quantify the effects of PhB. First signs of metrazol action (sharp elements and/or rhythmic metrazol activity) were not reliably influenced by PhB. On the contrary, the latency of the first EEG seizures as well as of the first generalized EEG seizures was prolonged and thus a dose necessary for their elicitation was increased in all age groups. These differences reached statistical significance in 12-, 18- and 25-day-old rats. A lack of effect of PhB against the rhythmic metrazol activity supports the adequacy of this activity as a model of human absences. Differences between the development of antiepileptic and hypnotic effects of PhB (described earlier) suggest two different mechanisms of action.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public