Trichostatin A inhibits rhabdomyosarcoma proliferation and induces differentiation through myomiR reactivation

Title:

Trichostatin A inhibits rhabdomyosarcoma proliferation and induces differentiation through myomiR reactivation

Creator:

Tarnowski, M., Tkacz, M., Kopytko, P., Bujak, J., Piotrowska, K., and Pawlik, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a2cf7f39-66fb-41d0-a541-8ff123527e2a
uuid:a2cf7f39-66fb-41d0-a541-8ff123527e2a

Subject:

rhabdomyosarcoma, TsA, muscle differentiation, myomiR, and miRNA

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Rhabdomyosarcoma (RMS) is a malignant tumour of soft tissues, occurring mainly in children and young adults. RMS cells derive from muscle cells, which due to mutations and epigenetic modifications have lost their ability to differentiate. Epigenetic modifications regulate expression of genes responsible for cell proliferation, maturation, differentiation and apoptosis. HDAC inhibitors suppress histone acetylation; therefore, they are a promising tool used in cancer therapy. Trichostatin A (TsA) is a pan-inhibitor of HDAC. In our study, we investigated the effect of TsA on RMS cell biology. Our findings strongly suggest that TsA inhibits RMS cell proliferation, induces cell apoptosis, and reactivates tumour cell differentiation. TsA up-regulates miR-27b expression, which is involved in the process of myogenesis. Moreover, TsA increases susceptibility of RMS cells to routinely used chemotherapeutics. In conclusion, TsA exhibits anti-cancer properties, triggers differentiation, and thereby can complement an existing spectrum of chemotherapeutics used in RMS therapy. and Corresponding author: Maciej Tarnowski

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

[43]-52

Source:

Folia biologica | 2019 Volume:65 | Number:1

Harvested from:

CDK

Metadata only:

false