The decrease of serum leptin levels in oestrogen-treated male mice

Title:

The decrease of serum leptin levels in oestrogen-treated male mice

Creator:

Nedvídková, J., Haluzík, M., and Schreiber, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b133820e-edc0-4f07-8774-4ba93fa6a2c1
uuid:b133820e-edc0-4f07-8774-4ba93fa6a2c1

Subject:

oestrogens, oestradiol-benzoate, leptin, cAMP, body weight, and mice

Type:

article, model:article, and TEXT

Description:

Adipocyte hormone leptin (OB protein) is considered to be an "adiposity signal" regulating body weight homeostasis and energy balance. We have previously reported that oestrogens (oestradiol-benzoate) significantly decrease the body weight in male rats, increase anterior pituitary and serum levels of the intracellular messenger cAMP, which activates cAMP-dependent protein kinase A , their targets include hormone-sensitive lipase and they influence the brain sympathetic system. The present study tested our hypothesis that oestrogens could influence serum leptin levels in male mice. We found that chronic administration of oestradiol-benzoate significantly attenuated serum levels of leptin, in the dependence on the duration of its administration, and simultaneously decreased body weight. We suppose that oestrogens affect leptin levels interacting with the signal transmission system of cAMP, possibly at the genome level. Our observations that the food consumption of mice with simultaneously decreased body weight and levels of serum leptin support the idea that there exists a satiety factor that counters the effect of low leptin.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1997 Volume:46 | Number:4

Harvested from:

CDK

Metadata only:

false