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Start Over Subject oestrogens

1. Methylene blue inhibition of oestradiol-induced increase of ceruloplasmin serum levels in rats

Creator:
Maruna, P., Mašek, Z., and Schreiber, V.
Type:
article, model:article, and TEXT
Subject:
ceruloplasmin, copper, oestrogens, and methylene blue
Language:
English
Description:
The administration of oestrogens increases the hepatic synthesis and plasma level of ceruloplasmin both in man and laboratory animals. Methylene blue, an oxidizing agent and inhibitor of soluble guanylate cyclase, is widely used to block the effects of endothelium-derived relaxing factor (nitric oxide). We describe the inhibitory effect of methylene blue on the increase of ceruloplasmin plasma level in rats during oestradiol treatment.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. The decrease of serum leptin levels in oestrogen-treated male mice

Creator:
Nedvídková, J., Haluzík, M., and Schreiber, V.
Type:
article, model:article, and TEXT
Subject:
oestrogens, oestradiol-benzoate, leptin, cAMP, body weight, and mice
Language:
English
Description:
Adipocyte hormone leptin (OB protein) is considered to be an "adiposity signal" regulating body weight homeostasis and energy balance. We have previously reported that oestrogens (oestradiol-benzoate) significantly decrease the body weight in male rats, increase anterior pituitary and serum levels of the intracellular messenger cAMP, which activates cAMP-dependent protein kinase A , their targets include hormone-sensitive lipase and they influence the brain sympathetic system. The present study tested our hypothesis that oestrogens could influence serum leptin levels in male mice. We found that chronic administration of oestradiol-benzoate significantly attenuated serum levels of leptin, in the dependence on the duration of its administration, and simultaneously decreased body weight. We suppose that oestrogens affect leptin levels interacting with the signal transmission system of cAMP, possibly at the genome level. Our observations that the food consumption of mice with simultaneously decreased body weight and levels of serum leptin support the idea that there exists a satiety factor that counters the effect of low leptin.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public