Sorafenib, risk of bleeding and spontaneous rupture of hepatocellular carcinoma. A clinical case

Title:

Sorafenib, risk of bleeding and spontaneous rupture of hepatocellular carcinoma. A clinical case
Sorafenib, risk of bleeding and spontaneous rupture of hepatocellular carcinoma. A clinical case

Creator:

Rombolà, Ferdinando, Caravetta, Angelo, Mollo, Francesco, Spinoso, Antonio, Peluso, Lenino, and Guarino, Raffaele

Contributor:

Rombolà, Ferdinando, Caravetta, Angelo, Mollo, Francesco, Spinoso, Antonio, Peluso, Lenino, and Guarino, Raffaele

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12000873-a856ee39-d40d-46f2-b27e-63ddd0252319
uuid:bmc12000873-a856ee39-d40d-46f2-b27e-63ddd0252319
local:bmc12000873
http://www.lfhk.cuni.cz/Data/files/Casopisy/2011/2011_177.pdf
local: bmc12000873

Subject:

staří, antitumorózní látky--škodlivé účinky, benzensulfonáty--škodlivé účinky, hepatocelulární karcinom--farmakoterapie--komplikace, krvácení--etiologie, lidé, nádory jater--farmakoterapie--komplikace, mužské pohlaví, pyridiny--škodlivé účinky, and spontánní ruptura--komplikace

Type:

model:article, article, Text, kazuistiky, and TEXT

Format:

braille, text, and regular print

Description:

Spontaneous rupture is a rare and dramatic complication of hepatocellular carcinoma (HCC), burdened by a high mortality. Here we describe a case of a 73-year-old man, who arrived at the ER because of syncope, and acute epigastric and right upper quadrant abdominal pain. He had a history of hepatitis C-related liver cirrhosis and HCC in treatment with sorafenib. The physical examination showed a state of hemorrhagic anemia with the presence of blood in the peritoneal cavity. The patient underwent an urgent liver resection. Thirty days after surgery, he was in good general condition. Sorafenib is a multikinase inhibitor recently introduced in the therapy of patients with advanced HCC. Among the various side effects reported in patients treated with sorafenib, there is a higher risk of bleeding. In conclusion, sorafenib may increase the risk of bleeding and rupture of HCC in susceptible individuals., Ferdinando Rombolà, Angelo Caravetta, Francesco Mollo, Antonio Spinoso, Lenino Peluso, Raffaele Guarino, and Literatura 15

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2011 Volume:54 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2011