Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer

Title:

Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer
Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer

Creator:

Paulík, Adam, Grim, Jiří, and Filip, Stanislav

Contributor:

Paulík, Adam, Grim, Jiří, and Filip, Stanislav , 1961-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc13037652-88da1aee-303c-47a2-b317-8d0dfdd013f0
uuid:bmc13037652-88da1aee-303c-47a2-b317-8d0dfdd013f0
local:bmc13037652
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/
local: bmc13037652

Subject:

antitumorózní látky fytogenní--škodlivé účinky--farmakokinetika--terapeutické užití, kamptothecin--škodlivé účinky--analogy a deriváty--farmakokinetika--terapeutické užití, kolorektální nádory--genetika--patologie, průjem--chemicky indukované, lidé, neutropenie--chemicky indukované, and farmakogenetika

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, přehledy, and TEXT

Format:

print, text, and regular print

Description:

The colorectal cancer ranks high among the malignant tumours in incidence and mortality and irinotecan is standardly used in palliative treatment of metastatic disease in every therapeutic line. Unfortunately, the treatment with irinotecan is often associated with severe toxicities, especially neutropenia and diarrhea. The majority of the toxic manifestation is caused by the insufficient deactivation (glucuronidation) of irinotecan active metabolite SN-38 by UGT1A enzyme. The elevated SN-38 plasma concentration is responsible for the hematological and gastrointestinal toxicity that can become life-threatening. The patients carrying the mutation of the gene encoding UGT1A enzyme lack the ability of bilirubin glucuronidation, and suffer from the inherited un-conjugated hyperbilirubinemia (Gilbert syndrome, Crigler-Najjar type 1 and 2 syndrome). The mutations in other enzyme systems also play role in the etiopathogenesis of the irinotecan toxicity: CYP3A (cytochrome P-450), ABC family of transmembrane transporters (adenosine-triphosphate binding cassette). The goal of the contemporary research is to determine the predictive factors that will enable the individual adjustment of the individual drug dosage while minimising the adverse effects and maintaining the treatment benefit. and A. Paulík, J. Grim, S. Filip

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2012