The occurrence of fetal microchimeric cells in endometrial tissues is very common phenomenon in benign uterine disorders and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses

Title:

The occurrence of fetal microchimeric cells in endometrial tissues is very common phenomenon in benign uterine disorders and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses
The occurrence of fetal microchimeric cells in endometrial tissues is very common phenomenon in benign uterine disorders and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses
Fetální mikrochimérismus v endometriální tkáni u benigních a nádorových onemocnění děložního těla

Creator:

Hromadníková, Ilona, Kotlabová, Kateřina, Pirkova, Petra, Líbalová, Pavla, Vernerová, Zdenka, Svoboda, Bohuslav, and Kučera, Eduard

Contributor:

Hromadníková, Ilona , 1970-, Kotlabová, Kateřina, Pirkova, Petra, Líbalová, Pavla, Vernerová, Zdenka , 1960-, Svoboda, Bohuslav , 1944-, and Kučera, Eduard , 1962-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14066875-f633a49b-9df5-4133-be8c-e2c2da3b3da2
uuid:bmc14066875-f633a49b-9df5-4133-be8c-e2c2da3b3da2
local:bmc14066875
http://www.actualgyn.com/pdf/cz_2014_113.pdf
local: bmc14066875

Type:

model:article, article, Text, statistics, abstrakt z konference, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Aims: This is the first study carried out to describe the role of fetal microchimerism (FM) in the pathogenesis of uterine cancer. The prevalence and concentration of male fetal microchimeric cells (FMCs) were examined in endometrial tissues in relation to subtypes of uterine cancer, and the histological grade and stage of the tumor. FM occurrence was analyzed in relation to risk factors including hypertension, obesity, type 2 diabetes, dyslipidemia, age at cancer diagnosis and patient pregnancy history. The prevalence and concentration of FMCs were examined in endometrial tissues using real-time polymerase chain reaction, SRY and b-globin sequences as markers for male fetal FMCs and total DNA. The studied group involved 47 type 1 endometrial cancers, 28 type 2 endometrial cancers and 41 benign uterine diseases. Results: While the prevalence of FM was decreased only in type 1 endometrial cancer, compared to benign uterine disorders (38.3% vs.70.7%; OR = 0.257, 95% CI: 0.105 to 0.628, p = 0.003), FMC concentrations did not differ within examined groups. The lower FM prevalence was detected in low grade (grade 1 and grade 2) endometrioid cancer (38.3% vs. 70.7%, OR = 0.256, 95% CI: 0.105 to 0.627, p = 0.003) and in FIGO 1 tumors (40.7% vs. 70.7%, OR= 0.285, 95% CI: 0.120 to 0.675, p = 0.004). No correlation between FM prevalence or FMC concentrations and risk factors was demonstrated. Conclusions: A lower prevalence of male FM seemed to be associated with better prognoses in uterine cancer based on tumor subtype, histological grade and stage of the tumor. and Ilona Hromadnikova, Katerina Kotlabova, Petra Pirkova, Pavla Libalova, Zdenka Vernerova, Bohuslav Svoboda, Eduard Kucera

Language:

Czech and English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Aktuální gynekologie a porodnictví--MED00165192

Source:

Aktuální gynekologie a porodnictví: recenzovaný on-line časopis | 2014 Volume:6

Harvested from:

CDK

Metadata only:

false

Date:

2014