Antioxidant vitamin levels and glutathione peroxidase activity during ischemia/reperfusion in myocardial infarction

Title:

Antioxidant vitamin levels and glutathione peroxidase activity during ischemia/reperfusion in myocardial infarction

Creator:

Mužáková, V., Roman Kanďár, Pavel Vojtíšek, Jiří Skalický, Vaňková, R., Alexander Čegan, and Zuzana Červinková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c4f7750c-6a63-4bd7-9c15-4189f463555f
uuid:c4f7750c-6a63-4bd7-9c15-4189f463555f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, infarkt myokardu, oxidační stres, myocardial infarction, oxidative stress, malondialdehyde, glutathione peroxidase, alpha tocopherol, beta carotene, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The consequences of increased oxidative stress, measured as the level of malondialdehyde (MDA) during ischemia/reperfusion, were studied in 48 patients in the acute phase of myocardial infarction (AMI) and a control group (21 blood donors). The serum levels of a-tocopherol and b-carotene were followed. Immediately after the treatment onset the level of a-tocopherol started to decrease, reaching a plateau after 24 h. The consumption of b-carotene was delayed by 90 min. Steady decline was detected during the whole time interval studied (48 h). Glutathione peroxidase (GPx) activity, as a representative of antioxidant enzymes, was estimated in whole blood. The influx of oxygenated blood was accompanied by a stimulation of GPx activity, which reached its maximum at the time of completed reperfusion. When comparing the AMI patients with the control group, the levels of MDA were found significantly increased, which indicates that oxidative stress is already increased during ischemia. Lower antioxidant levels found in the patients might either already be the result of vitamin consumption during ischemia or be a manifestation of their susceptibility to AMI. Monitored consumption of a-tocopherol and b-carotene during reperfusion indicated that in the case of patients, whose level of antioxidant vitamins is below the threshold limit, a further substantial decrease of antioxidant vitamins during reperfusion could enhance the oxidative damage of the myocardium., V. Mužáková, R. Kanďár, P. Vojtíšek, J. Skalický, R. Vaňková, A. Čegan, Z. Červinková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:4

Harvested from:

CDK

Metadata only:

false