Different functional responsibility of the small intestine to high-fat/high-energy diet determined the expression of obesity-prone and obesity-resistant phenotypes in rats

Title:

Different functional responsibility of the small intestine to high-fat/high-energy diet determined the expression of obesity-prone and obesity-resistant phenotypes in rats

Creator:

Šefčíková, Z., Hájek, T., Ľudovít Lenhardt, Raček, Ľ., and Mozeš, Š.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d79edebe-6d43-441d-9cc5-2f5ae13d3a49
uuid:d79edebe-6d43-441d-9cc5-2f5ae13d3a49
issn:0862-8408

Subject:

Obecná zoologie, fyziologie živočichů, obezita, krmiva, animal physiology, obesity, feeds, diet-induced obesity, intestinal functinality, feed efficiency, energy homeostasis, 2, and 591

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The objective of the present experiment was to assess the involvement of small intestine in expression of susceptibility or resistance to the high-fat/high-energy diet. The investigation was carried out in adult male Sprague-Dawley rats fed either standard laboratory diet (3.2 kcal/g, 9.5 % fat) or high-fat (HF) diet (4.04 kcal/g, 30 % fat) for 4 weeks as well as in HF rats that were retrospectively designated on the bases of their higher or lower weight gain as sensitive (DIO) or resistant (DR) to obesity. Our results revealed in HF group significant increase in energy intake, food efficiency, weight gain and Lee´s index of obesity. Moreover, in comparison with controls, a significantly increased duodenal and jejunal alkaline phosphatase (AP) and α-glucosidase activity as well as hypertrophy of jejunal mucosa (increased protein/DNA ratio) were observed in HF fed rats. In contrast, intestinal function was inversely related to energy intake or to the development of adiposity in DIO vs. DR rats. The DR rats had significantly greater AP and α-glucosidase activity and more pronounced suppression of energy intake than obese DIO rats. It indicates that the increase of enzyme activities and the lowered effectiveness of nutrient absorption might be a significant factor preventing the expression of obesity proneness. This information contributes to a better understanding of a complex interaction between HF diet feeding and small intestinal adaptability, which determines the energy homeostasis and predict the ability to resist or develop obesity in these phenotypes., Z. Šefčíková, T. Hájek, Ľ. Lenhardt, Ľ. Raček, Š. Možeš., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false