Early and late effects of hyperbaric oxygen treatment on oxidative stress parameters in diabetic patients

Title:

Early and late effects of hyperbaric oxygen treatment on oxidative stress parameters in diabetic patients

Creator:

Gürdöl, Figen, Cimşit, M., Öner-İyidoğan, Y., Körpinar, Ş., Yalçinkaya, S., and Koçak, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d7f67357-a083-49f6-8a18-5aa6e58ae600
uuid:d7f67357-a083-49f6-8a18-5aa6e58ae600
issn:0862-8408

Subject:

Biochemie. Molekulární biologie. Biofyzika, biochemie, hyperbarická oxygenoterapie, diabetická noha, biochemistry, hyperbaric medicine, diabetic foot, isoprostanes, malondialdehyde, advanced oxidation protein products, 2, and 577

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Exposure to hyperbaric oxygen leads to increased amount of reactive oxygen species (ROS) that are derived from various sources. After the discovery that ROS can function as signaling molecules, the idea of ROS being hazardous to biological tissues has been challenged. The aim of this study was to examine the changes in oxidative stress parameters in diabetics undergoing hyperbaric oxygen therapy (HBOT) due to foot ulcers. Twenty patients, who received HBOT for diabetic foot ulcers, were included in the study. Blood samples were taken before HBOT and 30 min after exit from the chamber, on the day of the first and the 15th HBOT sessions. They were used for the determinations of malondialdehyde (MDA), 8-isoprostane and advanced oxidation protein products (AOPPs). 8-Isoprostane and AOPP levels were not altered significantly after the first HBOT session, while both were increased on the fifteenth day (p<0.05). MDA was significantly increased only after the first HBOT session, and remained unchanged on the fifteenth day (within-day variations). Plasma AOPP levels were lowered significantly after fifteen consecutive HBOT sessions (between-day variations). Decreased AOPP levels suggest that increased oxygenation of tissues due to HBO therapy may activate some endogenous factors that prevent hazardous effects of the disease itself., F. Gürdöl, M. Cimşit, Y. Öner-İyidoğan, Ş. Körpinar, S. Yalçinkaya, H. Koçak., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false