Activity of paraoxonase 1 and lipid profile in healthy children

Title:

Activity of paraoxonase 1 and lipid profile in healthy children

Creator:

Katarína Sumegová, Nagyová, Z., Waczulíková, I., Žitňanová, I., and Zdeňka Ďuračková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e63a6206-a298-487e-99d3-4a68bef3b6df
uuid:e63a6206-a298-487e-99d3-4a68bef3b6df
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, biochemie, lipoproteiny, ateroskleróza, biochemistry, lipoproteins, atherosclerosis, vysokodenzitní lipoprotein, lipidové peroxidy, paraoxonáza 1, HDL (high-density lipoprotein), lipid peroxides, paraoxonase 1, TEAC (trolox equivalent antioxidant capacity), 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Paraoxonase 1 (PON1) seems to have a relevant role in detoxifying processes and in atherosclerosis. The aim of this study was to determine PON1 activity, the total antioxidant capacity, as well as entire lipid profile in children for screening of possible risk of atherosclerosis development. Serum PON1 arylesterase/paraoxonase activities were determined spectrophotometrically. The total antioxidant capacity of the serum was measured by TEAC method. Parameters of lipid profile were analyzed by routine laboratory methods. It has been shown that PON1 arylesterase/ paraoxonase activities were very similar to values found in adults. In children, no significant correlation between PON1 arylesterase activity and HDL was observed. PON1 paraoxonase activity correlated only with atherogenic index. PON1 arylesterase activity was significantly higher in girls than in boys. The antioxidant capacity was inversely related to the body mass index. In this study, PON1 activity was determined in healthy children aged 11 to 12 years and we found a similarity in PON1 activities of children and adults. Moreover, the results of our study support the hypothesis that higher body weight of children may contribute to a greater risk for development of atherosclerosis in which oxidative stress plays a role., K. Sumegová, Z. Nagyová, I. Waczulíková, I. Žitňanová, Z. Ďuračková., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:3

Harvested from:

CDK

Metadata only:

false