Cardiovascular parameters in rat model of chronic renal failure induced by subtotal nephrectomy

Title:

Cardiovascular parameters in rat model of chronic renal failure induced by subtotal nephrectomy

Creator:

Jitka Švíglerová, Jitka Kuncová, Lukáš Nalos, Zbyněk Tonar, Daniel Rajdl, and Milan Štengl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f25593a6-36f0-4835-bdc0-25bb701a1bfe
uuid:f25593a6-36f0-4835-bdc0-25bb701a1bfe

Subject:

Fyziologie člověka a srovnávací fyziologie, selhání ledvin, renal failure, rat, subtotal nephrectomy, cardiovascular complications, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Chronic renal failure (CRF) is associated with high incidence of cardiovascular complications. To clarify pathogenesis of CRF numerous animal models have been developed. The aim of our work was to describe methodology of subtotal surgical renal ablation in rat and to characterize some biochemical and cardiovascular parameters of this animal model. Male rats underwent 5/6 surgical nephrectomy or sham operations in two steps. The following parameters were measured on day 10 and in week 10 after the surgery: plasma concentrations of creatinine and urea, blood pressure, resting heart rate, chronotropic response to atropine and metipranol, heart ventricles weight, contraction parameters and action potential duration in the left ventricle. Increased serum concentrations of creatinine and urea, decreased creatinine clearance, polyuria and alteration of the remnant kidney tissue were found in CRF rats. Changes in cardiovascular parameters identified after subtotal nephrectomy resembled alterations of cardiovascular system in uremic patients and included hypertension, elevated resting heart rate, diminished parasympathetic cardiac tone, hypertrophy of the left ventricle associated with weakened force of contraction, prolonged contraction and relaxation and shortening of action potential duration. These data suggest that the present model can be a useful tool in the study of CRF and its cardiovascular complications., J. Švíglerová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false