Leptin and soluble leptin receptor changes after pulmonary endarterectomy: relations to cortisol and cytokine network

Title:

Leptin and soluble leptin receptor changes after pulmonary endarterectomy: relations to cortisol and cytokine network

Creator:

Pavel Maruna, Jaroslav Lindner, and Kubzová, K. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f25a55a3-6eaf-4fcd-8889-23f6114921aa
uuid:f25a55a3-6eaf-4fcd-8889-23f6114921aa

Subject:

Patologie. Klinická medicína, biochemie, leptin, biochemistry, plicní endarterektomie, pulmonary endarterectomy, soluble leptin receptor, interleukin-6, tumor necrosis factor-α, 14, and 616

Type:

article, články, model:article, and TEXT

Description:

Leptin is a hormone that regulates food intake. During inflammatory status, leptin may contribute to the anorexia and cachexia of infection. Pulmonary endarterectomy was used as a model of non-infectious cytokine network hyperstimulation. Leptin and soluble leptin receptor (SLR) were compared with evolution of cortisol and inflammatory cytokines in twenty-two patients with chronic thromboembolic pulmonary hypertension treated with pulmonary endarterectomy using cardiopulmonary bypass (CBP) and deep hypothermic circulatory arrest (DHCA). Leptin, SLR, cortisol, IL-1β, IL-6, IL-8, and TNFα concentrations in arterial blood were measured before/after sternotomy, last DHCA, separation from bypass, 12, 18, 24, 36, and 48 h after sternotomy. Mean duration of CPB was 338.2 min.; mean circulatory arrest time 39.9 min. The initial decline of leptin, SLR, TNFα, IL-6, and IL-8 was followed by an increase culminating 6-24 h after sternotomy. Leptin peak levels were detected 24 h after sternotomy (28.0 ng/ml, 21.9-37.6). IL-6 culminated after separation from CPB, IL-8 was highest 12 h after sternotomy. Leptin concentrations correlated with IL-6 (r=0.82), and TNFα (r=0.73). Large cardiovascular surgery caused a significant increase in serum leptin, indicating its acute regulation by stress factors. This effect may be secondary to the inflammatory response mediated via cytokine stimulation. Correlation between leptin and IL-6 indicates the role of IL-6 in leptin induction., P. Maruna, J. Lindner, K. M. Kubzová., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:4

Harvested from:

CDK

Metadata only:

false