Protein profiling of human atrial and ventricular musculature: the effect of normoxaemia and hypoxaemia in congenital heart diseases

Title:

Protein profiling of human atrial and ventricular musculature: the effect of normoxaemia and hypoxaemia in congenital heart diseases

Creator:

Pelouch, V., Milerová, M., Ošťádal, B., Šamánek, M., and Hučín, B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f50e3e76-3624-42c8-88b9-46ba4d2e90f1
uuid:f50e3e76-3624-42c8-88b9-46ba4d2e90f1

Subject:

protein profiling of cardiac muscle, contractile proteins, collagenous proteins, ATPase of atrial and ventricular myosin, congenital heart disease, tetralogy of Fallot, ventricular septal defect, and atrial septal defect

Type:

article, model:article, and TEXT

Description:

Samples of myocardial tissue were obtained during surgical intervention from children operated for different types of congenital heart disease (tetralogy of Fallot, ventricular and atrial septal defect). Sarcoplasmic, contractile and collagenous proteins were isolated by stepwise extraction from the both right ventricular and atrial musculature. It has been found that: a) the concentration of contractile proteins is significantly higher in the ventricles, b) the concentration of collagenous proteins is significantly higher in the atrium, c) the concentration of sarcoplasmic proteins was not different, d) in children with chronic hypoxia the above atrio-ventricular differences persisted. Moreover, the proportion of the soluble collagenous fraction in the atria was significantly increased.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:4

Harvested from:

CDK

Metadata only:

false