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Start Over Subject contractile proteins

2. Molecular aspects of regulation of cardiac contraction

Creator:
Pelouch, V.
Type:
article, model:article, and TEXT
Subject:
contractility of myocardium, isomyosins, contractile proteins, regulatory proteins, modulatory proteins, collagen, extracellular matrix proteins, and cardiac hypoxia
Language:
English
Description:
Contractility of the myocardium is determined by the interaction of contractile (actin and myosin) and regulatory (troponin and tropomyosin) proteins in the presence of calcium ions and chemical energy. The formation of the actomyosin complex is affected by the modulatory (C-, F-, M-proteins, actinins) and interstitial proteins (different types of collagens, glycoproteins, glycosaminoglycans, elastins). Cardiac hypoxia is accompanied by qualitative and quantitative changes in both collagenous (change in the proportion of different extracellular matrix proteins) and non-collagenous proteins (formation of different isomyosins and isoforms of actins or regulatory proteins). This remodelling of cardiac musculature influences significantly the process of contraction and relaxation in the hypoxic myocardium.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Protein profiling of human atrial and ventricular musculature: the effect of normoxaemia and hypoxaemia in congenital heart diseases

Creator:
Pelouch, V., Milerová, M., Ošťádal, B., Šamánek, M., and Hučín, B.
Type:
article, model:article, and TEXT
Subject:
protein profiling of cardiac muscle, contractile proteins, collagenous proteins, ATPase of atrial and ventricular myosin, congenital heart disease, tetralogy of Fallot, ventricular septal defect, and atrial septal defect
Language:
English
Description:
Samples of myocardial tissue were obtained during surgical intervention from children operated for different types of congenital heart disease (tetralogy of Fallot, ventricular and atrial septal defect). Sarcoplasmic, contractile and collagenous proteins were isolated by stepwise extraction from the both right ventricular and atrial musculature. It has been found that: a) the concentration of contractile proteins is significantly higher in the ventricles, b) the concentration of collagenous proteins is significantly higher in the atrium, c) the concentration of sarcoplasmic proteins was not different, d) in children with chronic hypoxia the above atrio-ventricular differences persisted. Moreover, the proportion of the soluble collagenous fraction in the atria was significantly increased.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public