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Start Over Creator Mareš, P. Subject hippocampus

1. Influence of flunarizine on hippocampal epileptic afterdischarges in the rat

Creator:
Pohl, M. and Mareš, P.
Type:
article, model:article, and TEXT
Subject:
epileptic afterdischarges, hippocampus, rat, and flunarizine
Language:
English
Description:
Epileptic afterdischarges elicited by electrical stimulation of the dorsal hippocampus in freely moving rats were not significantly changed by flunarizine administration in comparison with control sessions in which the animals received the solvent only. On the other hand, flunarizine significantly reduced the number of wet dog shakes, the main automatisms accompanying limbic afterdischarges.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Morphological shanges of the presynaptic and postsynaptic element in excitatory synapses during kindling

Creator:
Hovorka, J., Langmeier, M., and Mareš, P.
Type:
article, model:article, and TEXT
Subject:
kindling, hippocampus, synapse, postsynaptic element, and presynaptic bag
Language:
English
Description:
In a previous study of a kindling model using stimulation of the entorhinal cortex we found a redistribution of synaptic vesicles into the close vicinity of the active zone of synapses of Type I (Gray 1959) in the hippocampal gyrus dentatus. In this paper, ultrastructural studies of the same model are being continued using planimetry of the synaptic apparatus. A significant increase of the postsynaptic apparatus, area enlargement by 53 %, increase of the perimeter by 28 % and shape irregularity are being reported. No changes in shape or in size have been demonstrated in presynaptic structures or in the morphology of presynaptic mitochondria. These findings are discussed in relation to increased functional readiness of the synapses as signs of active reconstruction of the synaptic apparatus.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. The action of pramiracetam on consequences of hypobaric hypoxia is only moderate

Creator:
Marešová, D. and Mareš, P.
Type:
article, model:article, and TEXT
Subject:
pramiracetam, hypoxia, epileptic afterdischarges, and hippocampus
Language:
English
Description:
The possible protective action of pramiracetam, a pyrrolidinone nootropic drug, against hypobaric hypoxia was studied in two age groups of immature rats with implanted electrodes. Epileptic afterdischarges induced by hippocampal stimulation were used as a measure of hypoxic damage. Pramiracetam did not substantially change these afterdischarges in 12- and 18-day-old rat pups which were not exposed to hypoxia. Hypobaric hypoxia (simulated altitude of 7000 m for one hour) led to prolongation of the first afterdischarge in both age groups. Pramiracetam did not influence this prolongation in 12-day-old rats. The first afterdischarge was shortened significantly in 18-day-old animals but not to the level of rats not exposed to hypoxia. The afterdischarges elicited by repeated stimulations (four times at 10 min intervals) did not differ in pramiracetam-treatcd and control rats.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public