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1. Olfactory bulbectomy induced oxidative and cell damage in rat: protective effect of melatonin

Creator:
Tasset, I., Medina, F. J., Peña, J., Jimena, I., Del Carmen Muñoz, M., Salcedo, M., Ruiz, C., Feijóo, M., Montilla, P., and Túnez, I.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, antioxidanty, deprese, melatonin, oxidační stres, antioxidants, depression, oxidative stress, olfactory bublectomy, 14, and 612
Language:
English
Description:
In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations., I. Tasset ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public