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1. AL-amyloidóza se zaměřením na renální manifestace

Creator:
Švec-Billá, D., Havrda, Martin, Krátká, Karolína, Gregora, Evžen, Pavlíček, P., Vernerová, Zdenka, and Kučera, Petr
Format:
print, text, and regular print
Type:
model:article, article, Text, abstrakt z konference, and TEXT
Language:
Czech
Description:
D. Švec-Billá, M. Havrda, K. Krátká, E. Gregora, P. Pavlíček, Z. Vernerová, P. Kučera
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Fetální mikrochimérismus u karcinomu endometria

Creator:
Hromadníková, Ilona, Kotlabová, Kateřina, Vernerová, Zdenka, Svoboda, Bohuslav, and Líbalová, Pavla
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, abstrakt z konference, and TEXT
Language:
Czech and English
Description:
Ilona Hromadníková, Kateřina Kotlabová, Zdeňka Vernerová, Bohuslav Svoboda, Pavla Líbalová
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

4. Pharmacological stimulation of Wnt/beta-catenin signaling pathway attenuates the course of thioacetamide-induced acute liver failure

Creator:
Koblihová, Eva, Mrázová, Iveta, Vaňourková, Zdenka, Maxová, Hana, Kikerlová, Soňa, Husková, Zuzana, Ryska, Miroslav, Froněk, Jiří, and Vernerová, Zdenka
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
acute liver failure, thioacetamide, and Wnt/β-catenin signaling pathway
Language:
English
Description:
Acute liver failure (ALF) is known for extremely high mortality rate, the result of widespread damage of hepatocytes. Orthotopic liver transplantation is the only effective therapy but its application is limited by the scarcity of donor organs. Given the importance in the liver biology of Wnt/β-catenin signaling pathway, we hypothesized that its stimulation could enhance hepatocyte regeneration and attenuate the course of thioacetamide (TAA)-induced ALF in Lewis rats. Chronic treatment with Wnt agonist was started either immediately after hepatotoxic insult (“early treatment”) or when signs of ALF had developed (“late treatment”). Only 23 % of untreated Lewis rats survived till the end of experiment. They showed marked increases in plasma alanine aminotransferase (ALT) activity and bilirubin and ammonia (NH3) levels; plasma albumin decreased significantly. “Early” and “late” Wnt agonist treatment raised the final survival rate to 69 % and 63 %, respectively, and normalized ALT, NH3, bilirubin and albumin levels. In conclusion, the results show that treatment with Wnt agonist attenuates the course of TAA-induced ALF in Lewis rats, both with treatment initiated immediately after hepatotoxic insult and in the phase when ALF has already developed. Thus, the pharmacological stimulation of Wnt/β-catenin signaling pathway can present a new approach to ALF treatment.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. The occurrence of fetal microchimeric cells in endometrial tissues is very common phenomenon in benign uterine disorders and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses

Creator:
Hromadníková, Ilona, Kotlabová, Kateřina, Pirkova, Petra, Líbalová, Pavla, Vernerová, Zdenka, Svoboda, Bohuslav, and Kučera, Eduard
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, abstrakt z konference, and TEXT
Language:
Czech and English
Description:
Aims: This is the first study carried out to describe the role of fetal microchimerism (FM) in the pathogenesis of uterine cancer. The prevalence and concentration of male fetal microchimeric cells (FMCs) were examined in endometrial tissues in relation to subtypes of uterine cancer, and the histological grade and stage of the tumor. FM occurrence was analyzed in relation to risk factors including hypertension, obesity, type 2 diabetes, dyslipidemia, age at cancer diagnosis and patient pregnancy history. The prevalence and concentration of FMCs were examined in endometrial tissues using real-time polymerase chain reaction, SRY and b-globin sequences as markers for male fetal FMCs and total DNA. The studied group involved 47 type 1 endometrial cancers, 28 type 2 endometrial cancers and 41 benign uterine diseases. Results: While the prevalence of FM was decreased only in type 1 endometrial cancer, compared to benign uterine disorders (38.3% vs.70.7%; OR = 0.257, 95% CI: 0.105 to 0.628, p = 0.003), FMC concentrations did not differ within examined groups. The lower FM prevalence was detected in low grade (grade 1 and grade 2) endometrioid cancer (38.3% vs. 70.7%, OR = 0.256, 95% CI: 0.105 to 0.627, p = 0.003) and in FIGO 1 tumors (40.7% vs. 70.7%, OR= 0.285, 95% CI: 0.120 to 0.675, p = 0.004). No correlation between FM prevalence or FMC concentrations and risk factors was demonstrated. Conclusions: A lower prevalence of male FM seemed to be associated with better prognoses in uterine cancer based on tumor subtype, histological grade and stage of the tumor. and Ilona Hromadnikova, Katerina Kotlabova, Petra Pirkova, Pavla Libalova, Zdenka Vernerova, Bohuslav Svoboda, Eduard Kucera
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public