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1. 5. Beethoven-Studienkolleg: Beethoven edieren. Einführung in die Editionstechnik

Creator:
Petra Kolátorová
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Beethoven, Ludwig van, 1770-1827, 2011-2020, hudební konference, muzikologie, conferences on music, musicology, Bonn (Německo), Bonn (Germany), 78.01, 78:005.745, and (046)
Language:
Czech
Description:
Příspěvek Petry Kolátorové je věnován mezinárodní muzikologické konferenci, která se uskutečnila v německém Bonnu ve dnech 27. až 29. srpna 2012., Petra Kolátorová., Rubrika: Konference, and Cizojazyčné resumé není.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. 7 věží: Karel IV. v hledáčku akademiků

Creator:
Marina Hužvárová
Format:
print, bez média, and svazek
Type:
article, biography, články, journal articles, model:article, and TEXT
Subject:
Historická věda. Pomocné vědy historické. Archivnictví, IV., český král a římský císař, Karel, 1316-1378, Akademie věd České republiky, historiografie, panovníci, interdisciplinární aspekty, historiography, kings and rulers, interdisciplinary aspects, Česko, Czechia, 8, and 930
Language:
Czech
Description:
The 700th birth anniversary of King of Bohemia and Holy Roman Emperor Charles IV has been designated as one of UNESCO´s important world anniversaries for 2016-2017. The Czech Academy of Sciences recreates the period of Charles IV at the exhibiton entitled Seven Towers. Charles IV through the eyes of academics (1316-2016) at the Science and Art Gallery. The visitors have an oppportunity to see the unique gold ducats with a picture of Charles IV. For this first time the most valuable archaeological discoveries of glass goblets are exhibited. Everyday items used by residents of the medieval city are also on display. The exhibition also shows a rare treasure of coins, which was hidden in the Emmaus monastery about 1370, as well as copies of the Constitutive Act of the Charles University, Charles´s Code Maiestas Carolina or late-medieval transcript of Charles´ Golden Bull. Personality of Charles IV is documented by commemorative coins, medals and seals bearing his image. Part of the exhibition is also a faithful copy of the statue of Charles IV from the Old Town Bridge Tower, the last sculptural portrait of the monarch before his death. and Marina Hužvárová.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Acrylamide: a common food toxin related to physiological functions and health

Creator:
Semla, M., Goc, Z., Martiniaková, M., Omelka, R., and Formicki, G.
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, akrylamid, genotoxicita, oxidační stres, acrylamide, genotoxicity, oxidative stress, neurotoxicity, reproductive toxicity, 14, and 612
Language:
English
Description:
Acrylamide (AA) is a highly reactive organic compound capable of polymerization to form polyacrylamide, which is commonly used throughout a variety of industries. Given its toxic effect on humans and animals, the last 20 years have seen an increased interest in research devoted to the AA. One of the main sources of AA is food. AA appears in heated food following the reaction between amino acids and reduced sugars. Large concentrations of AA can be found in popular staples such as coffee, bread or potato products. An average daily consumption of AA is between 0.3-2.0 μg/kg b.w. Inhalation of acrylamide is related with occupational exposure. AA delivered with food is metabolized in the liver by cytochrome P450. AA biotransformation and elimination result in formation of toxic glycidamide (GA). Both, AA and GA can be involved in the coupling reaction with the reduced glutathione (GSH) forming glutathione conjugates which are excreted with urine. Biotransformation of AA leads to the disturbance in the redox balance. Numerous research proved that AA and GA have significant influence on physiological functions including signal propagation in peripheral nerves, enzymatic and hormonal regulation, functions of muscles, reproduction etc. In addition AA and GA show neurotoxic, genotoxic and cancerogenic properties. In 1994, International Agency for Research on Cancer (IARC) classified acrylamide as a potentially carcinogenic substance to human., M. Semla, Z. Goc, M. Martiniaková, R. Omelka, G. Formicki., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

4. Adult neurogenesis in the hippocampus from a perspective of discrimination and generalization: a hypothesis

Creator:
Pistikova, A., Brozka, H., and Aleš Stuchlík
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, diskriminace, fyziologie, discrimination, physiology, adult neurogenesis, function, generalization, spatial memory, pattern Separation, 14, and 612
Language:
English
Description:
The function of adult neurogenesis in the dentate gyrus is not yet completely understood, though many competing theories have attempted to explain the function of these newly -generated neurons. Most theories give adult neurogenesis a role in aiding known hippocampal/dentate gyrus functions. Other theories offer a novel role for these new cells based on their unique physiological qualities, such as their low excitability threshold. Many behavioral tests have been used to test these theories, but results have been inconsistent and often contradictory. Substantial variability in tests and protocols may be at least partially responsible for the mixed results. On the other hand, conflicting results arising from the same tests can serve as aids in elucidating the function of adult neurogenesis. Here, we offer a hypothesis that considers the cognitive nature of tasks commonly used to assess the function of adult neurogenesis, and introduce a dichotomy between tasks focused on discrimination vs. generalization. We view these two aspects as opposite ends of the continuous spectrum onto which traditional tests can be mapped. We propose that high neurogenesis favors behavioral discrimination while low adult neurogenesis favors behavioral generalization of a knowledge or rule. Since many tasks require both, the effects of neurogenesis could be cancelled out in many cases. Although speculative, we hope that our view presents an interesting and testable hypothesis of the effect of adult neurogenesis in traditional behavioral tasks. We conclude that new, carefully designed behavioral tests may be necessary to reach a final consensus on the role of adult neurogenesis in behavior., A. Pistikova, H. Brozka, A. Stuchlik., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. Aerobic exercise of low to moderate intensity corrects unequal changes in BKCa subunit expression in the mesenteric arteries of spontaneously hypertensive rats

Creator:
Zhang, Y., Chen, Y., Zhang, L., Lu, N., and Shi, L.
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, hypertenze, hypertension, exercise intensity, BKCa channel, 14, and 612
Language:
English
Description:
Accumulating evidence indicates that hypertension is associated with "ion channel remodeling" of vascular smooth muscle cells (VSMCs). The objective of this study was to determine the effects of exercise intensity/volume on hypertension-associated changes in large-conductance Ca2+-activated K+ (BKCa) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHR). Male SHRs were randomly assigned to three groups: a low-intensity aerobic exercise group (SHR-L: 14 m/min), a moderate-intensity aerobic exercise group (SHR-M: 20 m/min), and a sedentary group (SHR). Age-matched Wistar-Kyoto rats (WKYs) were used as normotensive controls. Exercise groups completed an 8-week exercise program. Elevation of the α and β1 proteins was unequal in MA myocytes from SHRs, with the β1 subunit increasing more than the α subunit. BKCa contribution to vascular tone regulation was higher in the myocytes and arteries of SHRs compared to WKYs. SHR BKCa channel subunit protein expression, β1/α ratio, whole cell current density and single-channel open probability was also increased compared with WKYs. Aerobic exercise lowered systemic blood pressure and normalized hypertension-associated BKCa alterations to normotensive control levels in the SHRs. These effects were more pronounced in the moderate-intensity group than in the low-intensity group. There is a dose-effect for aerobic exercise training in the range of low to moderate-intensity and accompanying volume for the correction of the pathological adaptation of BKCa channels in myocytes of MAs from SHR., Y. Zhang, Y. Chen, L. Zhang, N. Lu, L. Shi., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

7. Algoritmy pro detekci život ohrožujících arytmií

Creator:
Filip Plešinger Filip Plešinger, Klimeš, Petr, Pavel Jurák, and Josef Halámek
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Ústav přístrojové techniky (Akademie věd ČR), lékařské přístroje, elektrofyziologie, algoritmy, medical instruments and apparatus, electrophysiology, algorithms, 12, and 00
Language:
Czech
Description:
Filip Plešinger, Petr Klimeš, Josef Halámek, Pavel Jurák.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8. Americké protiraketové základny v ČR a Polsku z pohledu domácí veřejnosti

Creator:
Jan Červenka
Format:
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Type:
article, články, journal articles, model:article, and TEXT
Subject:
Společenské vědy, výzkum veřejného mínění, public opinion polls, U.S. missile defence, public opinion, Czech Republic, Poland, 18, and 3
Language:
Czech
Description:
V ČR a Polsku se v posledním období významným zahraničněpolitickým i vnitropolitickým tématem stal záměr vlády USA umístit v těchto zemích některé komponenty budovaného amerického systému obrany proti mezikontinentálním balistickým střelám, který by podle deklarovaného záměru měl chránit kontinentální území Spojených států před případným útokem prostřednictvím menšího počtu raket dlouhého doletu z tzv. „ničemných států“ (rogue states), jak je označuje americká administrativa. Vlády ČR a Polska byly v tomto směru nedávno oficiálně americkou stranou požádány diplomatickou nótou o jednání v této záležitosti. V případě Polska by se mělo jednat o odpalovací zařízení raket určených k ničení mezikontinentálních balistických střel, na českém území by pak měl být dislokován radar, jehož prostřednictvím protiraketový systém vyhledává nepřátelské střely a navádí na ně své rakety. Probíhající diskuse jak uvnitř obou oslovených středoevropských států, tak i na mezinárodním foru zřetelně ukazují, že jak konkrétní plán umístit základny antibalistické obrany v ČR a Polsku, tak zejména samotný záměr budovat byť i jen omezený systém strategické obrany tohoto druhu, představuje závažnou, značně citlivou a kontroverzní otázku s globálním dosahem. Pochopitelný a průběžně sílící zájem o věc projevují také obyvatelé obou zemí. A právě postojům české a polské veřejnosti k celému projektu, jejich aktuálnímu stavu a také možnému dalšímu vývoji se bude věnovat tento text., The text focuses on public opinion in Czech Republic and Poland relating to the plan of U.S. government to locate some parts of U.S. national missile defence in these countries. It describes and compares main shifts of developments of public attitudes in both countries to the project as well as to eventual referendum in this matter within the period up to the first half of 2007. The text shows main demographical, societal and political differences in both countries and discusses reasons and motives behind particular attitudes of Czech and Polish citizens., Jan Červenka., and Seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

9. An alternatively activated macrophage marker CD163 in severely obese patients: the influence of very low-calorie diet and bariatric surgery

Creator:
Cinkajzlová, A., Zdeňka Lacinová, Kloučková, J., Petra Kaválková, Trachta, P., Mikuláš Kosák, Krátký, J., Mojmír Kasalický, Karin Doležalová, Mráz, M., and Martin Haluzík
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, obezita, diabetes mellitus, tuková tkáň, obesity, adipose tissue, type 2 diabetes mellitus, macrophages, 14, and 612
Language:
English
Description:
CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients. Plasma sCD163 levels were increased in obese and T2DM subjects relative to control subjects (467.2±40.2 and 513.8±37.0 vs. 334.4±24.8 ng/ml, p=0.001) and decreased after both interventions. Obesity decreased percentage of CD163+CD14+ monocytes in peripheral blood compared to controls (78.9±1.48 vs. 86.2±1.31 %, p=0.003) and bariatric surgery decreased CD163+CD14+HLA-DR+ macrophages in SAT (19.4±2.32 vs. 11.3±0.90 %, p=0.004). Our data suggest that increased basal sCD163 levels are related to obesity and its metabolic complications. On the contrary, sCD163 or CD163 positive cell changes do not precisely reflect metabolic improvements after weight loss., A. Cinkajzlová, Z. Lacinová, J. Kloučková, P. Kaválková, P. Trachta, M. Kosák, J. Krátký, M. Kasalický, K. Doležalová, M. Mráz, M. Haluzík., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

10. An evaluation of velocity estimates with a correlated noise: case study of IGS ITRF2014 European stations

Creator:
Klos, Anna and Bogusz, Janusz
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, GPS sítě, GPS netwoks, ITRF2014, noise analysis, velocity, 7, and 551
Language:
English
Description:
The velocities of the Global Positioning System (GPS) stations are widely employed for numerous geodynamical studies. The aim of this paper is to investigate the reliability of station velocities and to draw reader’s attention that for proper estimates of velocity, we need to consider the optimal character of noise. We focus on a set of 115 European GPS stations which contributed to the newest release of the International Terrestrial Reference Frame (ITRF), i.e. ITRF2014. Based on stacked Power Spectral Densities (PSDs), we show that amplitudes o f seasonal signals are significant for nine harmonics of tropical year (365.25 days) and two harmonics of draconitic year (351.60 days). The amplitudes of tropical annual signal fall between 0.1-8.4 mm and are much higher for vertical component than for horizontal. Draconitic annual signal reaches the maximum amplitudes of 1.2 and 0.9 mm for North and East, respectively, whereas is slightly higher for the Up component with a maximum of 3.1 mm. We performed a noise analysis with Maximum Like lihood Estimation (MLE) and found that stations in Central and Northern Europe are characterized by spectral index between flicker and random-walk noise, while stations in Southern and Western Europe: between white and flicker noise. Both amplitudes and spectral indices of power-law noise show a spatial correlation for Up component. We compared the uncertainties of velocities derived in this study with a combination of power-law and white noises to the ones offici ally released in the ITRF2014 with a pure white noise. A ratio of the two estimates is larger than 10 for 13 % and 30 % of stations in horizontal and vertical direction, respectively with medians of 6 and 7. The large differences support the fact that at the velocity determination the proper noise characteristic should be taken into account to avoid any mislead interpretation., Anna Klos and Janusz Bogusz., and Obsahuje bibliografické odkazy
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public