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16595. Variability and systematic status of Zonorchis clathratum (Trematoda: Dicrocoeliidae), a parasite of swifts and swallows

Creator:
Sitko, J.
Format:
print
Type:
model:internalpart and TEXT
Subject:
Dicrocoeliidae, Zonorchis, and swifts and swallows
Language:
English
Description:
The morphometrical variability of Zonorchis clalhraium (Deslongschamps, 1824) from Apus apus in the Czech Republic, Z. rutshurensis (Baer, 1959) from Apus cajffer streubeli and Z. dureni Vercammen-Grandjean, 1960 from Hirundo ni-grita in Congo was studied. Zonorchis rulshurensis and Z dureni are considered to be synonyms of Z. clathratum. Lyperosomum oswuldoi Travassos, 1919 sensu Jaroń, 1969 is considered to beZ. clathratum, and L. clathratum (Deslongschamps, 1824) sensu Jaroń, 1969 is considered to be Stromitremu koschewnikovi (Skryabin et Massino, 1925).
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

16596. Variability of Mammary Carcinogenesis Induction in Female Sprague-Dawley and Wistar:Han Rats: the Effect of Season and Age

Creator:
Kubatka, P., Eva Ahlersová, Ivan Ahlers, Bianka Bojková, Kalická, K., Eva Adámeková, Marková, M., Chamilová, M., and Čermáková, M.
Format:
print, bez média, and svazek
Type:
article, studie, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Mammary carcinogenesis, Seasons, Critical periods, Rat strains, Susceptibility, 14, and 612
Language:
English
Description:
It is important to determine and clarify the variability of mammary carcinogenesis induction in animal experimental studies particularly in connection with chemoprevention projects. The circannual seasonal rhythms of hormone levels or various parameters within the immune system may involve factors participating in mammary gland carcinogenesis. In our study, 19 experiments were conducted and all of them lasted for about 25 weeks after chemical carcinogen administration (DMBA or NMU) under standard laboratory conditions. Females of two rat strains - a medium susceptible Sprague-Dawley strain and a very low susceptible Wistar:Han were used. We observed not only the effect of seasonal changes but also the effect of age after single or repeated carcinogen administration. The seasonal dependence of mammary carcinogenesis with higher tumor incidence during long days in comparison with winter short days has been demonstrated in Sprague-Dawley rats. In experiments on the Wistar:Han strain, certain features of seasonal character were recorded, although the very low susceptibility of this strain to mammary carcinogenesis might have influenced the results. A limited period of carcinogen administration in early puberty around postnatal days 43-46 (higher susceptibility), when compared to the period after postnatal day 50, is the factor significantly increasing incidence and frequency of mammary carcinogenesis in the Sprague-Dawley strain. Our results indicate the need to consider the effect of season and age of animals at the time of carcinogen administration on rat mammary carcinogenesis induction. However, the application of the results obtained in one strain of experimental animals may only lead to misleading conclusions., P. Kubatka, E. Ahlersová, I. Ahlers, B. Bojková, K. Kalická, E. Adámeková, M. Marková, M. Chamilová, M. Čermáková., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

16597. Variability of species of Babesia Starcovici, 1893 in three sympatric ticks (Ixodes ricinus, Dermacentor reticulatus and Haemaphysalis concinna) at the edge of Pannonia in the Czech Republic and Slovakia

Creator:
Rybářová, Markéta, Honsová, Michaela, Ivo Papoušek, and Pavel Široký
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
parazitologie, parasitology, host-specificity, piroplasms, species diagnosis, 18S rRNA, 2, and 59
Language:
English
Description:
The distribution, variability and host specificity of species of Babesia Starcovici, 1893 were studied in questing ticks collected on the northwestern edge of the Pannonian Basin in the south-easternmost part of the Czech Republic and in western Slovakia. The area is characterised by relatively natural floodplain habitats and the sympatric occurrence of three tick species possessing wide host spectra, namely Ixodes ricinus (Linnaeus), Dermacentor reticulatus (Fabricius) and Haemaphysalis concinna Koch. Analysis was carried out on 1,408 I. ricinus, 2,999 D. reticulatus and 150 H. concinna altogether, collected from 59 localities. We documented the presence of Babesia spp. not only in I. ricinus but also in H. concinna in the Czech Republic. Two isolates from I. ricinus were classified as B. venatorum Herwaldt, Cacciò, Gherlinzoni, Aspöck, Slemenda, Piccaluga, Martinelli, Edelhofer, Hollenstein, Poletti, Pampiglione, Löschenberger, Tura et Pieniazek, 2003 (formerly determined as Babesia sp. EU1), which is a zoonotic parasite and can cause human babesiosis. The rest of our amplicons were very similar to B. canis (Piana et Galli-Valerio, 1895), which is usually transmitted by D. reticulatus. Despite the huge amount of examined samples, all D. reticulatus ticks were Babesia-free. Due to this finding, we did not consider our obtained isolates to be B. canis, but other closely related species possessing a similar sequence of the studied portion of 18S rDNA. Although this genetic marker is most frequently used in PCR-based diagnostic methods of babesias, its low variability compromises its reliability in studies based only on this marker., Markéta Rybářová, Michaela Honsová, Ivo Papoušek, Pavel Široký., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

16598. Variable expression of hypercholesterolemia in apolipoprotein E2* (Arg136 - Cys) Heterozygotes

Creator:
Jaroslav Hubáček, Jan Piťha, Petr Stávek, Schmitz, G., and Rudolf Poledne
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, sekvenování DNA, metabolismus lipidů, DNA sequencing, lipid metabolism, apolipoprotein E, rare mutation, PCR, 14, and 612
Language:
English
Description:
In the process of population screening for apo E gene polymorphism with the PCR and subsequent restriction analysis, we identified a female who demonstrated heterozygosity for an unusual restriction fragment caused by the loss of a CfoI restriction site. Sequence analysis of the apo E gene was performed and a carrier of the mutant allele with C - T substitution at cDNA position 3817 was identified, which caused an Arg136 - Cys change. The first-line relatives have been screened for this rare mutation with PCR and restriction analysis of PCR products. The complete lipoprotein parameters have been determined in the probands family. In the family, only one child had the same mutant allele as his mother had. The proband (7.49 mmol/l) with her siblings had hypercholesterolemia and a high body mass index (BMI 31.6 kg/m2). By contrast, her son had a normal lipid spectrum with normal BMI. We described the mutation apo E2* (Arg136 - Cys) in a family with elevated lipid levels, but there was no confirmation of the connection between this mutation and type III hyperlipoproteinemia or hyperlipoproteinemia at all. In the case of this mutation, other factors (mainly genetic) are important for the development of lipid metabolism disorders., J. A. Hubáček, J. Piťha, P. Stávek, G. Schmitz, R. Poledne., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

16600. Variační počet, přirozený aparát fyziky

Creator:
Musilová, Jana and Musilová, Pavla
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
variační počet, variační metody, physics, calculus of variations, variational methods, matematická estetika, variační matematika, variační fyzika, 6, and 53
Language:
Czech and English
Description:
Říká se, že jedním ze znaků správné fyzikální teorie je její krása. Máme-li na mysli estetičnost matematickou, patří variační počet k matematickým metodám, které naplňují tento požadavek vrchovatě. Je také pravda, že správné (zkušeností a experimentem prověřené) fyzikální teorie bývají variační, tj. odvoditelné z variačního principu: Klasická mechanika, relativistická mechanika, kvantová mechanika, klasická elektrodynamika... Na zcela elementární úrovni předkládáme základní myšlenku a klasické postupy variačního počtu, s ukázkami použití v geometrii a fyzice. Zaměříme se pouze na variační princip prvního řádu, s důrazem na mechaniku, kde na rozdíl od teorie pole závisí řešené úlohy pouze na jedné nezávisle proměnné, ve fyzice obvykle na čase., It is said that one of the characteristic features of physical theories is their beauty. Having in mind the "mathematical aesthetic appearance" one can say that the calculus of variations highly fulfils this requirement! It is also well known that correct physical theories (those verified experimentally), are often variational, i.e. based on a variational principle: classical mechanics, relativistic mechanics, quantum mechanics, classical electrodynamics, etc. We present, at a very basic level, the fundamental ideas and classical approaches of the calculus of variations, including examples of their use in geometry and physics. We focus on the first order variational principle, emphasizing mechanics, because contrary to field theories, the variational problems in mechanics depend on one independent variable only (usually time in physics)., Jana Musilová, Pavla Musilová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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