Number of results to display per page
Search Results
39322. Minulost, současnost a budoucnost hvězdné astronomie a "česká ulička"
- Creator:
- Harmanec, Petr
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- stelární astronomie, astrofyzika, interferometrie, stellar astronomy, astrophysics, interferometry, 6, and 53
- Language:
- Czech
- Description:
- Petr Harmanec.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
39323. Minulost, současnost a budoucnost vesmíru podle Petra Kulhánka: Petr Kulhánek: Jak vznikal svět aneb třináctero příběhů o kosmologii
- Creator:
- Dočkal, Miroslav
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- vesmír, universe, 6, and 53
- Language:
- Czech
- Description:
- [autor recenze] Miroslav Dočkal.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
39324. Minulost, současnost i budoucnost Ústavu molekulární genetiky AV ČR
- Creator:
- Václav Hořejší
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Ústav molekulární genetiky (Akademie věd ČR), molekulární genetika, biotechnologie, molecular genetics, biotechnology, 12, and 00
- Language:
- Czech
- Description:
- Václav Hořejší. and fot.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
39325. Minus total domination in graphs
- Creator:
- Xing, Hua-Ming and Liu, Hai-Long
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- minus domination, total domination, and minus total domination
- Language:
- English
- Description:
- A three-valued function $f\: V\rightarrow \{-1,0,1\}$ defined on the vertices of a graph $G=(V,E)$ is a minus total dominating function (MTDF) if the sum of its function values over any open neighborhood is at least one. That is, for every $v\in V$, $f(N(v))\ge 1$, where $N(v)$ consists of every vertex adjacent to $v$. The weight of an MTDF is $f(V)=\sum f(v)$, over all vertices $v\in V$. The minus total domination number of a graph $G$, denoted $\gamma _t^{-}(G)$, equals the minimum weight of an MTDF of $G$. In this paper, we discuss some properties of minus total domination on a graph $G$ and obtain a few lower bounds for $\gamma _t^{-}(G)$.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
39326. Minute ventilation stabilization during all pressure-control / support mechanical ventilation modes
- Creator:
- Candík, Peter , Depta, Filip , Imrecze, Štefan , Sabol, František , Kolesar, Adrián , Jankajova, Monika , Paulíny, Matúš , Benova, Janka , Galková, Katarína , Donic, Viliam , and Török, Pavol
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- artificial lung ventilation, pressure controlled modes, and automatic proportional minute ventilation
- Language:
- English
- Description:
- The main goal of our prospective randomized study was comparing compare the effectiveness of ventilation control method „Automatic proportional minute ventilation (APMV) “versus manually set pressure control ventilation modes in relationship to lung mechanics and gas exchange. 80 patients undergoing coronary artery bypass grafting (CABG) were randomized into 2 groups. 40 patients in the first group No. 1 (APMV group) were ventilated with pressure control (PCV) or pressure support ventilation (PSV) mode with APMV control. The other 40 patients (control group No.2) were ventilated with synchronized intermittent mandatory ventilation (SIMV-p) or pressure control modes (PCV) without APMV. Ventilation control with APMV was able to maintain minute ventilation more precisely in comparison with manual control (p<0.01), similarly deviations of ETCO2 were significantly lower (p<0.01). The number of manual corrections of ventilation settings was significantly lower when APMV was used (p<0.01). The differences in lung mechanics and hemodynamics were not statistically significant. Ventilation using APMV is more precise in maintaining minute ventilation and gas exchange compared with manual settings. It required less staff intervention, while respiratory system mechanics and hemodynamics are comparable. APMV showed as effective and safe method applicable on top of all pressure control ventilation modes.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
39327. Miotic action of tramadol is determined by CYP2D6 genotype
- Creator:
- Ondřej Slanař, Milan Nobilis, Jaroslav Květina, Rudolf Mikoviny, Tomáš Zima, Jeffrey R. Idle, and František Perlík
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Farmacie. Farmakologie, farmakokinetika, cytochromy, genotyp, pharmacokinetics, cytochromes, genotype, cytochrom P450 2D6, miosa, tramadol, cytochrome P450 2D6, miosis, 14, and 615
- Language:
- English
- Description:
- Polymorphic CYP2D6 is the enzyme that activates the opioid analgesic tramadol by O-demethylation to its active metabolite O-demethyltramadol (M1). Our objective was to determine the opioid effects measured by pupillary response to tramadol of CYP2D6 genotyped volunteers in relation to the disposition of tramadol and M1 in plasma. Tramadol displayed phenotypic pharmacokinetics and it was possible to identify poor metabolizers (PM) with >99 % confidence from the metabolic ratio (MR) in a single blood sample taken between 2.5 and 24 h post-dose. Homozygous extensive metabolizers (EM) differed from PM subjects by an almost threefold greater (P=0.0014) maximal pupillary constriction (Emax). Significant correlations between the AUC and Cmax values of M1 versus pupillary constriction were found. The corresponding correlations of pharmacokinetic parameters for tramadol itself were weaker and negative. The strongest correlations were for the single-point metabolic ratios at all sampling intervals versus the effects, with rs ranging from 0.85 to 0.89 (p‹0.01). It is concluded that the concept of dual opioid/non-opioid action of the drug, though considerably stronger in EMs, is valid for both EM and PM subjects. This is the theoretical basis for the frequent use and satisfactory efficacy of tramadol in clinical practice when given to genetically non-selected population., O. Slanař, M. Nobilis, J. Květina, R. Mikoviny, T. Zima, J. R. Idle, F. Perlík., and Obsahuje biblografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
39328. Mír Takí Mír: Poezie
- Creator:
- Daňhel, Tomáš
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
39329. MiR-18a inhibits PI3K/AKT signaling pathway to regulate PDGF-BB-induced airway smooth muscle cell proliferation and phenotypic transformation
- Creator:
- Yang, Wei, Chen, Yunbin, Huang, Chao, Wang, Wenjian, Huang, Congfu, and Li, Yuanguang
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- miR-18a, PDGF-BB, airway smooth muscle cells (ASMCs), airway remodeling, and PI3K/AKT pathway
- Language:
- English
- Description:
- The increased proliferation and migration of airway smooth muscle cells (ASMCs) is a key process in the formation of airway remodeling in asthma. In this study, we focused on the expression of mircoRNA-18a (miR-18a) in airway remodeling in bronchial asthma and its related mechanisms. ASMCs are induced by platelet-derived growth factor BB (PDGF-BB) for in vitro airway remodeling. The expression of miR-18a in sputum of asthmatic patients and healthy volunteers was detected by qRT-PCR. The expression of miR-18a was over-expressed or interfered with in PDGF-BB-treated ASMCs. Cell proliferation, apoptosis and migration were detected by MTT, flow cytometry and Transwell, respectively, the expression of contractile phenotype marker proteins (SM-22α, α-SM-actin, calponin) and key molecules of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway (PI3K, p-PI3K, AKT and p-AKT) in ASMCs were detected by Western blot. The expression of miR-18a was down-regulated in the sputum and PDGF-BB-treated ASMCs of asthma patients. PDGF-BB could promote the proliferation and migration of ASMCs and inhibit their apoptosis, it could also promote the phenotypic transformation of ASMCs and activate the PI3K/AKT pathway. MiR-18a could inhibit the proliferation, migration ability and phenotypic transformation of ASMCs induced by PDGF-BB to a certain extent and alleviate the effect of PDGF-BB in supressing apoptosis, while miR-18a could inhibit the activation of the PI3K/AKT pathway. MiR-18a inhibits PDGF-BB-induced proliferation, migration and phenotypic conversion of ASMCs by inhibiting the PI3K/AKT pathway, thus attenuating airway remodeling in asthma.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
39330. miR-29a is a potential protective factor for fibrogenesis in gluteal muscle contracture
- Creator:
- Zhou, Ri, Ren, Shiyou, Li, Canfeng, Zhang, Xintao, and Zhang, Wentao
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- gluteal muscle contracture, miR-29a, fibrosis, HSP47, and TGF-β1
- Language:
- English
- Description:
- Circulating miRNAs have been proposed as the effective diagnostic biomarkers for muscular fibrosis-associated diseases. However, circulating biomarkers for early diagnosis of contracture muscles are limited in gluteal muscle contracture (GMC) patients. Here we sought to explore the abnormally expressed miRNAs in plasma and contraction bands of GMC patients. The results showed miR-29a-3p expression in plasma and contraction bands tissue was significantly reduced in GMC patients compared with normal control. Cell viability and levels of proliferation-associated protein cyclin D1 and cyclindependent-kinase 2 (CDK2) were powerfully inhibited by miR-29a mimics and enhanced by miR-29a inhibitor compared with negative control. Furthermore, miR-29a mimics effectively impeded, while miR-29a inhibitor enhanced the expression of collagen I and collagen III, followed by the secretion of transforming growth factor β1 (TGF-β1), TGF-β3 and connective tissue growth factor (CTGF) in primary human contraction bands (CB) fibroblasts. The miR-29a-3p negatively regulated the expression of TGF-β1 through binding to the 3′ UTR region of SERPINH1 (encoding heat shock protein HSP47), but had no effect on Smad2 activity. The miR-29a-3p was inversely correlated with HSP47 in contraction bands tissue from GMC patients. Collectively, miR-29a was notably depressed and regulated cell viability and fibrosis by directly targeting HSP47 in GMC, which suggest that circulating miR-29a might be a potential biomarker for early diagnosis and provides a novel therapeutic target for GMC.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public