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32. Neurovascular compression: sympathetic activity in severe arterial hypertension

Creator:
Miroslav Solař, Jiří Ceral, Jan Žižka, and Pavel Eliáš
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, vnitřní lékařství, arteriální hypertenze, magnetická rezonanční tomografie, internal medicine, arterial hypertension, magnetic resonance tomography, neurovaskulární komprese, neurovascular compression, 14, and 616
Language:
English
Description:
Compression of the rostral ventrolateral medulla oblongata (RVLM) by an abnormally located artery is regarded as one possible cause of arterial hypertension. There exists a limited set of data suggesting that increased sympathetic activity in patients with RVLM compression may lead to arterial hypertension. Accordingly, we decided to assess the sympathetic activity in patients with severe arterial hy pertension and to investigate any correlation with the presence of RVLM compression. Sixty-four patients with severe arterial hypertension were enrolled in our study. Sympathetic activity was evaluated using 24-hour urinary norepinephrine as measured by high-pressure liquid chromatography with electrochemical detection. The presence of RVLM compression was assessed with magnetic resonance imaging. Neurovascular compression of the RVLM was identified in 40 patients, 27 of whom presented left-sided compression. Twenty-four hour urinary norepinephrine averaged 263.6± 135.9 nmol in patients with neurovascular compression - 255.6±137.3 nmol in those with left-sided compression and 251.6±138.5 nmol in patients without RVLM compression. We did not identify any increase in urinary norepinephrine in patients with severe arterial hypertension and neurovascular compression of the RVLM. Our results do not support the hypothesis that neurovascular compression of RVLM may exhibit a sympathetically mediated increase in blood pressure., M. Solař ... [et al.]., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

33. New clearance evaluation method for hepatological diagnostics

Creator:
Josef A. Tichý, Miloslav Loučka, Trefný, Z. M., Markéta Hojerová, Jiří Svačinka, Müller, J., and Michaela Friedrichová
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, fyziologie, farmakokinetika, nelineární regresní modely, physiology, pharmacokinetics, nonlinear regression models, steatofibrosis hepatis (SFH), indocyanin green, two-compartment model, non-linear regression analysis, clearance value, T-index, 14, and 616
Language:
English
Description:
Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical mode l, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinic al interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient., J. A. Tichý ... [et al.]., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

35. O nedoslýchavosti, hluchotě a ochraně sluchu

Creator:
Josef Císler
Publisher:
Nákladem J. Otty
Format:
print and 77 s.
Type:
model:monograph and TEXT
Subject:
Patologie. Klinická medicína, otorinolaryngologie, poruchy sluchu, nedoslýchavost, hluchota, prevence onemocnění, otorhinolaryngology, hearing disorders, hypacusis, deafness, prevention of diseases, 616.21, 616.28-008.12/.14, 616.28-008.14, 616-084, (0.062), 14, and 616
Language:
Czech
Description:
širšímu obecenstvu nastínil Josef Císler. and KČSN
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

37. O významu pohlavních nemocí pro ženu, rodinu a společnost

Creator:
Václav Rubeška and Česká eugenická společnost
Publisher:
Nakladatelství J. Otto
Format:
print, svazek, and 20 stran.
Type:
model:monograph and TEXT
Subject:
Patologie. Klinická medicína, sexuálně přenosné nemoci, sociální aspekty, sexually transmitted diseases, social aspects, 14, and 616
Language:
Czech
Description:
Václav Rubeška., (Předneseno v lidových přednáškách c.k. České university v Praze v kursu 1916, pořádaném péčí České eugenické společnosti v Praze), and Přívazek k : Jaroslav Kříženecký / Ochrana mládeže a eugenika
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

38. Ontogenetic development of cardiac tolerance to oxygen deprivation - possible mechanisms

Creator:
Bohuslav Ošťádal, Ivana Ošťádalová, František Kolář, Zuzana Charvátová, and Ivan Netuka
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, kardiologie, hypoxie, ischemie, ontogeneze, cardiology, hypoxia, ischemia, ontogeny, odolnost srdce, ochrana srdce, cardiac tolerance, cardiac protection, 14, and 616
Language:
English
Description:
Our present focus on the hypoxic immature heart is driven by clinical urgency: cyanotic congenital cardiac malformations remain the single largest cause of mortality from congenital defects and ischemic heart disease is no more the disease of the fifth and older decades but its origin as well as risk factors are present already during early ontogeny. Moreover, the number of adult patients operated for cyanotic congenital heart disease during infancy steadily increases. This group approaches the age of the rising risk of serious cardiovascular diseases, particularly ischemic heart disease. Experimental results have clearly shown that the immature heart is significantly more tolerant to oxygen deficiency than the adult myocardium. However, the mechanisms of this difference have not yet been satisfactorily clarified; they are likely the result of developmental changes in cardiac energy metabolism, including mitochondrial function. The high resistance of the newborn heart cannot be further increased by ischemic preconditioning or adaptation to chronic hypoxia; these protective mechanisms appear only with decreasing tolerance during development. Resistance of the adult myocardium to acute oxygen deprivation may be significantly influenced by perinatal hypoxia. These results suggest that the developmental approach offers new possibilities in the studies of pathogenesis, prevention and therapy of critical cardiovascular diseases., B. Ošťádal ... [et al.]., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

40. Positive effect of oral supplementation with glycosaminoglycans and antioxidants on the regeneration of osteochondral defects in the knee joint

Creator:
Milan Handl, Evžen Amler, Bräun, K., Holzheu, J., Tomáš Trč, Imhoff, A. B., Lytvynets, A., Elena Filová, Hana Kolářová, Arnošt Kotyk, and Václav Martínek
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, experimentální medicína, chrupavka, experimental medicine, cartilage, glycosaminoglycans, oral supplementation, osteochondral lesion, 14, and 616
Language:
English
Description:
The effect of oral supplementation with glycosaminoglycans (GAG) and radical scavengers (vitamin E/selenium) on the regeneration of osteochondral defects was investigated in rabbits. After introduction of defined osteochondral defects in the knee joint, groups of ten animals were given a GAG/vitamin E/selenium mixture or a placebo (milk sugar) for 6 weeks. Following sacrifice, histological and histochemical analysis was performed. The amount of synovial fluid was increased in the placebo group, while the viscosity of the synovial fluid was significantly enhanced in the GAG group. The amount of sulfated GAG in the osteochondral regenerates (8.8±3.6 % vs. 6.0±5.6 %; p<0.03) was significantly higher in the GAG group. In both groups, the GAG amount in the cartilage of the operated knee was significantly higher than in the non-involved knee (p<0.05). Histological analysis of the regenerates in the GAG group was superior in comparison with the placebo group. For the first time, a biological effect following oral supplementation with GAG was demonstrated in healing of osteochondral defects in vivo. These findings support the known positive clinical results., M. Handl, E. Amler, K. Bräun, J. Holzheu, T. Trč, A. B. Imhoff, A. Lytvynets, E. Filová, H. Kolářová, A. Kotyk, V. Martínek., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public