Helicobacter pylori has been implicated in stimulation of immune system, development of autoimmune endocrinopathies as autoimmune thyroiditis (AT) and on other hand induction of immunosupresion activates gastric and extra-gastric diseases such as gastric ulcer or cancer. It causes persistent lifelong infection despite local and systemic immune response. Our results indicate that Helicobacter pylori might cause inhibition of the specific cellular immune response in Helicobacter pyloriinfected patients with or without autoimmune diseases such as AT. We cannot also declare the carcinogenic effect in oropharynx. However the association of any infection agents and cancerogenesis exists. The adherence of Helicobacter pylori expression and enlargement of benign lymphatic tissue and the high incidence of the DNA of Helicobacter pylori in laryngopharyngeal and oropharyngeal cancer is reality. LTT appears to be a good tool for detection of immune memory cellular response in patients with Helicobacter pylori infection and AT. All these complications of Helicobacter pylori infection can be abrogated by successful eradication of Helicobacter pylori., J. Astl, I. Šterzl., and Obsahuje bibliografii
Several deleterious effects may occur when intense and exhaustive exercise (IE) is not well-planned. This study aimed to investigate the effects of a short duration IE on body chemical composition and hypothalamic-pituitary-adrenal (HPA) axis. C57Bl/6 mice were distributed into four groups (10 mice per group): control (C-4D and C-10D), 4 days (E-4D), and 10 days of IE (E-10D). IE program consisted of a daily running session at 85 % of maximum speed until the animal reached exhaustion. Body weight as well as total body water, fat and protein content were determined from animal carcasses. HPA activation was assessed by plasma corticosterone levels measured by radioimmunoassay and the weight of both the adrenal glands and thymus were measured. Plasma corticosterone levels increased by 64 % in both the E-4D and E-10D groups. The weight of the adrenal glands augmented by 74 % and 45 %, at 4 and 10 days of IE, respectively, whereas thymus weight diminished by 15 % only in the E-10D group. The total carcass fat content decreased by 20 % only at 4 days IE, whereas protein content decreased by 20 % in both E-4D and E-10D groups. A relationship between corticosterone plasma levels and loss of body protein content in both E-4D and E-10D groups was observed (R2=0.999). We concluded that IE may be related to HPA axis activation associated with remodeling of body chemical composition in C57BL/6 mice., E. F. Rosa, G. A. Alves, J. Luz, S. M. A. Silva, D. Suchecki, J. B. Pesquero, J. Aboulafia, V. L. A. Nouailhetas., and Obsahuje bibliografii
Triiodothyronine administration before partial hepatectomy increased the activity of mitochondrial glycerophosphate cytochrome c reductase. The enzyme activity was further activated after partial hepatectomy during the regenerative process. Our findings showed that: a) the increase of glycerophosphate cytochrome c reductase induced by triiodothyronine was further potentiated by the regeneration process, b) the high activity of the glycerophosphate shuttle was maintained after partial hepatectomy during the period, when most of the liver tissue had again been recovered., H. Lotková, H. Rauchová, Z. Drahota., and Obsahuje bibliografii
Objectives of the study were to investigate impact of ischemic preconditioning (Ipre) and sulforaphane (SFN) and combination of them on nuclear factor 2 erythroid related factor 2 (Nrf2) gene and its dependent genes, heme oxygenase-1 (HO1) and NADPHquinone oxidoreductase1 (NQO-1) and inflammatory cytokines TNF-α, IL1β, and intercellular adhesion molecule-1 (ICAM1) and caspase-3 in renal ischemia/reperfusion (I/R) injury. Ninety male Sprague Dawely rats were classified into 5 groups (each consists of 18 rats): sham, control, Ipre, sulforaphane and Sulfo+Ipre. Each group was subdivided into 3 subgroups each containing 6 rats according to time of harvesting kidney and taking blood samples; 24 h, 48 h, and 7 days subgroups. Renal functions including serum creatinine, BUN were measured at basal conditions and by the end of experiment. Expression of Nrf2, HO-1, NQO-1, TNF-α, IL-1β, and ICAM-1 was measured by real time PCR in kidney tissues by the end of experiment. Also, immunohistochemical localization of caspase-3 and chemical assay of malondialdehyde (MDA), GSH and SOD activity were measured in kidney tissues. Both Ipre and SFN improved kidney functions, enhanced the expression of Nrf2, HO-1, and NQO-1, attenuated the expression of inflammatory (TNF-α, IL-1, and ICAM-1) and apoptotic (caspase-3) markers. However, the effect of sulforaphane was more powerful than Ipre. Also, a combination of them caused more improvement in antioxidant genes expression and more attenuation in inflammatory genes but not caspase-3 than each one did separately. Sulforaphane showed more powerful effect in renoprotection against I/R injury than Ipre as well as there might be a synergism between them at the molecular but not at the function level., A. A. Shokeir, N. Barakat, A. M. Hussein, A. Awadalla, A. M. Harraz, S. Khater, K. Hemmaid, A. I. Kamal., and Obsahuje bibliografii
Trusses are suitable load-bearing structural systems for heavy concentrated loads. In this paper, it is shown that it is possible to use active control mechanisms to enhance the load-bearing capacity of the trusses. Under heavy loading, some elernents of a truss might experience high stresses and show non-linear behavior, resulting in large deformations in the truss. Under such a condition, some elernents of the truss might damage which can lead to the collapse of the truss. Application of control forces on some of the degrees of freedom of the truss can render help the truss tolerate larger forces before its collapse. A neural network can then be trained to learn the relationship between the Information about the external loads on the truss, as input, and the required control forces, as output, and act as a neuro-controller for the truss. This method is explained and then tested on a smáli truss to show the capabilities of the method.
Some philosophers hold that it would be impossible for us to do something actively if the physical world were causally closed, i.e., if in the physical world all events were caused by other physical events if they are caused at all. The reason for this view is that these philosophers adhere to what I call the traditional picture of action. Recently, Martine Nida-Rümelin tried to defend this picture by phenomenological considerations. According to the traditional picture a behavior can only count as something an agent does actively if it is ultimately caused by the agent in an agent-causal way. In this paper I adduce three arguments against agent causation: (1) We do not really understand what agent causation is. (2) If agent causation were real, we would be confronted with the strange fact that human agents can only cause certain tiny events in the brain. (3) There is no empirical evidence that agent causation is real. In the last part of my paper I present an alternative account of the difference between what agents do actively and what is done to them., Někteří filosofové se domnívají, že by bylo pro nás nemožné něco aktivně činit, kdyby byl fyzický svět kauzálně uzavřen, tj. Kdyby byly všechny události způsobeny jinými fyzickými událostmi, kdyby byly ve fyzickém světě způsobeny vůbec. Důvodem tohoto názoru je, že tito filozofové dodržují to, čemu říkám tradiční obraz jednání. Nedávno se Martine Nida-Rümelin pokusila tento obraz obhájit fenomenologickými úvahami. Podle tradičního obrazu se chování může počítat pouze jako něco, co agent dělá aktivně, pokud je nakonec způsobeno agentem v kauzálním způsobu. V tomto příspěvku uvádím tři argumenty proti příčinám agenta: (1) Opravdu nechápeme, co je to příčina agenta. (2) Pokud byla příčinná souvislost agenta skutečná, byli bychom konfrontováni s podivnou skutečností, že lidští agenti mohou v mozku způsobit jen určité drobné události. (3) Neexistují žádné empirické důkazy, že příčinná souvislost agentů je skutečná. V poslední části mé práce uvádím alternativní popis rozdílu mezi tím, co agenti aktivně dělají a co se s nimi děje., and Ansgar Beckermann
I review some aspects of recent studies of active galactic nuclei (AGN) and their environments. My approach is from the hypothesis that a single AGN phenomenon includes the plethora of object classes whose acronyms pervade the literature. Particular attention is given to the mechanisms of interaction between the cetral engine and its environment, both with regard to the ways in which the observed radiation is produced on a range of spatial scales and to the ways in which the activity is related to outside influences.
This paper examines the results of fault microdisplacement analyses obtained from sites located both at the surface and underground in western Slovakia. The results of surface monitoring showed significant annual climatic effects on the various displacement components. In contrast, the results of underground monitoring in caves showed minimal climatic effects. It is seen that the influence of climate decreases markedly with depth. The yearly peak-to-peak amplitude of climatic variations may be as high as 1 mm at the surface but only 0.1 mm underground. The amount of tectonic displacement can be determined once such climatic considerations have been taken into account. Our fault displacement measurements show horizontal strike-slip rates of tenths of mm or hundredths of mm per year. In addition, vertical displacements have been recorded at Prekážka Quarry, Driny Cave, and Slopy Cave. The network is sufficiently dense to identify changes in displacement activity recorded during recent, significant, earthquake events. Furthermore, three gauges have also helped to determine the local stress orientation in Driny Cave., Miloš Briestenský, Blahoslav Košťák, Josef Stemberk, Ľubomír Petro, Jozef Vozár and Lucia Fojtíková., and Obsahuje bibliografii
One of the leaved out fault active systems at Southern Moravian can be considered the so called Diendorf - Čebín tectonic zone (DCTZ), that is seismically active in its southern segment (in Austrian). The Waitzendorf fault is a part of the DCTZ, with intensive morphological signs. The terrain recognizance along the eastern margin of the Dyje Dome confirmed many indi cations showing evidence of geodynamic activity. The facets, old land slides and rock falls indicate recent activity in the environs of Znojmo area. The paper offers interpretation of the geodetic results (GPS) using morphological and geophysical data from all area of the DCTZ ., Lubomil Pospíšil, Pavel Roštínský, Otakar Švábenský, Josef Weigel and Michal Witiska., and Obsahuje bibliografické odkazy
The effect of 30 % defoliation of shaded leaves in lower layers of plant was studied on activities of carbonic anhydrase (CA) and ribulose-1,5-bisphosphate carboxylase (RuBPC), leaf dry mass per unit leaf area, and plant dry mass of mustard (Brassica juncea). Removal of 30 % of leaves resulted in increased CA and RuBPC activities of leaves, and leaf and plant dry masses.