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3173. Boldine attenuates cholestasis associated with nonalcoholic fatty liver disease in hereditary hypertriglyceridemic rats fed by high-sucrose diet

Creator:
Zagorova, M., Prasnicka, A., Kadova, Z., Eva Doleželová, Ludmila Kazdová, Jolana Cermanová, Rozkydalova, L., Miloš Hroch, Mokry, J., and Stanislav Mičuda
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, játra, physiology, liver, nonalcoholic fatty liver disease, high-sucrose diet, boldine, bile flow, bsep, 14, and 612
Language:
English
Description:
The aim of the current study was to clarify the effect of high sucrose diet (HSD) on bile formation (BF) in rats with hereditary hypertriglyceridemia (HHTg). Potentially positive effects were studied for boldine, a natural choleretic agent. Administration of HSD to HHTg rats led to increased triglyceride deposition in the liver. HSD reduced BF as a consequence of decreased biliary secretion of bile acids (BA) and glutathione. Responsible mechanism was down-regulation of hepatic transporters for BA and glutathione, Bsep and Mrp2, respectively. Moreover, gene expressions of transporters for other constituents of bile, namely Abcg5/8 for cholesterol, Abcb4 for phospholipids, and Oatp1a4 for xenobiotics, were also reduced by HSD. Boldine partially attenuated cholestatic effect of HSD by promotion of biliary secretion of BA through up-regulation of Bsep and Ntcp, and by increase in biliary secretion of glutathione as a consequence of its increased hepatic disposition. This study demonstrates mechanisms of impaired BF during nonalcoholic fatty liver disease induced by HSD. Altered function of responsible transporters suggests also potential for changes in kinetics of drugs, which may complicate pharmacotherapy in subjects with high intake of sucrose, and with fatty liver disease. Sucrose induced alterations in BF may be alleviated by administration of boldine., M. Zagorova, A. Prasnicka, Z. Kadova, E. Dolezelova, L. Kazdova, J. Cermanova, L. Rozkydalova, M. Hroch, J. Mokry, S. Micuda., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3174. Bolívie: země indigenního environmentalismu? Několik úvah nad paradoxy bolivijského politického projektu

Creator:
Jetmarová, Jana
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Bolivia, environmentalism, indigenous, hydrocarbons, lithium, and Evo Morales
Language:
Czech
Description:
The article ponders over the environmental paradoxes of the Bolivian political project. The government of Morales aspires to establish a system based on social justice, environmentally conscious politics and the respect for the indigenous populations of the country. The new Political Constitution was adopted that guarantees the political, cultural and territorial rights of the indigenous groups and delineates a well-developed framework of the environmental protection. As one of the first states of the world Bolivia admitted the legal status of nature and adopted „Law of Mother Earth“. However, to these legislative measures contrasts sharply the economic strategy of the country, based almost exclusively on mining, industrialization and commercialization of the natural resources. The government of Morales intensified the mining of the fossil fuels and prepares the way for a gigantic project of mining and processing of lithium on the Bolivian salt flats. Socio-ecological consequences of these activities might be catastrophic. We think that the ambivalent environmental attitude of the government of Morales is caused, primarily, by its effort to match up two inconsistent principles: on the one hand the anthropocentric concept of economic growth, modernity and progress and on the other the indigenous concept of „good life“ that became the official moral-ethical principle of the Bolivian state.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3175. Bolzano in Prague 2014

Creator:
Betti, Arianna and Russ, Steve
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Bolzano, Bernard, 1781-1848, mezinárodní konference, filozofie, international conferences, philosophy, Praha (Česko), Prague (Czechia), 12, and 00
Language:
Czech
Description:
Thirty-five 35 participants from 13 countries gathered at Villa Lanna July 16-19, 2014 to hear and discuss presentations on the life and work of one of the foremost European philosophers of the 19th century, Bernard Bolzano. Most of the 30 talks given were on philosophy but mathematics and theology. More than a quarter of the participants were research students. Several news stories have drawn attention to recent developments in Bolzano studies. In May the complete English translation of Bolzano’s major work Wissenschaftslehre (Theory of Science) was published. This year nearly three-quarters of the129 volumes of the Bernard Bolzano Gesamtausgabe will appear in print. The program and other details of the meeting can be found at bolzano2014.wordpress.com. The meeting enjoyed generous sponsorship. Details on the dissemination of the papers will appear in due course. This meeting was co-organised by the Institute of Philosophy of ASCR and the International Bernard Bolzano Society, Salzburg. The Society met in Prague in April 2010 on the 200th anniversary of a book of his published in 1810. Dr. Balzano (1781-1848) was a Bohemian mathematician, logician, philosopher and theologian of Italian extraction and taught at the University of Prague (Charles). and Arianna Betti, Steve Russ.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3177. Bone marrow-derived cells participate in composition of the satellite cell niche in intact and regenerating mouse skeletal muscle

Creator:
Čížková, D., Komárková, Z., Bezrouk, A., Macháčková, L., Vávrová, J., Filip, S., and Mokrý, J.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
satellite cells, bone marrow cells, satellite cell niche, transplantation, and skeletal muscle regeneration
Language:
English
Description:
The cellular components of the satellite cell niche participate in the regulation of skeletal muscle regeneration. Beside myogenic cells at different developmental stages, this niche is formed by cells of the immune system, the interstitial connective tissue and the vascular ystem. Unambiguous determination of the origin of these cell types could contribute to optimization of the cell-based therapy of skeletal muscle disorders. In our work, we intravenously transplanted mouse GFP+ unseparated bone marrow cells into whole-body lethally irradiated immunocom-petent mice four weeks before cardiotoxin-induced injury of the recipients’ skeletal muscles. Seven and 28 days after the toxin injection, the injured regenerating and contralateral intact muscles were examined for identification of GFP+ bone marrow-derived cells by direct fluorescence, protein immunohistochemistry and immunogold transmission electron microscopy. In both the intact and injured muscles, GFP positivity was determined in immune cells, mainly in macrophages, and in interstitial spindle-shaped cells. Moreover, in the injured muscles, rare GFP+ endothelial cells of the blood vessels and newly formed myotubes and muscle fibres were present. Our results confirmed the ability of bone marrow-derived cells to contribute to the cellular component of the satellite cell niche in the intact and regenerating skeletal muscle. These cells originated not only from haematopoietic stem cells, but obviously also from other stem or progenitor cells residing in the bone marrow, such as multipotent mesenchymal stromal cells and endothelial progenitors. and Corresponding author: Dana Čížková
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3178. Bone microstructure of mice after prolonged taurine treatment

Creator:
Martiniakova, M. , Sarocka, A., Babosova, R. , Galbavy, D. , Kapusta, E., Goc, Z., Formicki, G. , and Omelka, R.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
taurine, bone, mouse, and microstructure
Language:
English
Description:
Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group – mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group – mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine – treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3179. Bone mineral density in patients with apolipoprotein E type 2/2 and 4/4 genotype

Creator:
Tomáš Štulc, Richard Češka, Aleš Hořínek, and Jan Štěpán
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, osteoporóza, vitamin K, osteoporosis, bone mineral density, bone turnover, apolipoprotein E, 14, and 612
Language:
English
Description:
The peak bone mass and the rate of bone loss are in part genetically determined. It has been suggested that bone mineral density (BMD) may be related to allelic variation in the apolipoprotein E (ApoE) gene locus. ApoE is important in the receptor-mediated clearance of chylomicron particles from the plasma, Apo E4 having the highest and Apo E2 the lowest receptor affinity. Chylomicrons are the main carrier of vitamin K in the plasma; vitamin K plays an important role in the carboxylation of osteocalcin. We have tested the hypothesis that persons with E4 variant would have lower BMD and increased bone turnover than those with E2 variant. A total of 18 ApoE 2/2 and ApoE 4/4 homozygotes were selected from 873 patients who were examined for the ApoE genotype. BMD in lumbar vertebral, femoral neck and distal forearm was measured and plasma concentrations of osteocalcin and C-terminal fragments of collagen (CTx) were determined. BMD values (expressed as T-score) at the three specified sites were -0.12± 1.72, -0.52± 1.32 and -0.52± 0.81 in ApoE 2/2 group and -0.24± 1.22, 0.00± 0.84 and -0.17± 1.07 in the ApoE 4/4 group. Plasma osteocalcin and CTx were within normal limits in both groups. In conclusion, we did not observe any association of ApoE genotype with BMD and biochemical markers of bone metabolism in ApoE 2/2 and ApoE 4/4 homozygotes., T. Štulc, R. Češka, A. Hořínek, J. Štěpán., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3180. Bone remodeling, particle disease and individual susceptibility to periprosthetic osteolysis

Creator:
Jiří Gallo, Milan Raška, František Mrázek, and Martin Petřek
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Experimentální medicína, patologická fyziologie, osteoklasty, ortopedie, pathological physiology, osteoclasts, orthopedics, periprotetická osteolýza, osteoblast, periprosthetic osteolysis, particle disease, basic multicellular unit, 14, and 616-092
Language:
English
Description:
Bone remodeling is a tightly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, which operate in conjunction with local and systemic factors in a discrete anatomic structure designated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influenced by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this may lead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have been reported in the past, including RANKL/RANK/OPG/TRAF6, TNF-α/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expression and functional activity of all these molecules can be affected by variations in their genes. These may explain the differences in severity of bone defects or prosthetic failure between patients with similar wear rates and the same prosthesis. Simultaneously, this data strongly support the theory of individual susceptibility to prosthetic failure., J. Gallo, M. Raška, F. Mrázek, M. Petřek., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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