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135. Effect of DRD2/ANKK1 taqIA allelic polymorphism on the risk and prognosis of cervical precancer and cancer

Creator:
Cseh, József, Orsós, Zsuzsa, Pázsit, Emese, Marek, Erika, Huszár, András, Ember, István, and Kiss, István
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
cervikální intraepiteliální neoplazie--etiologie--genetika, prekancerózy--genetika, cervix uteri--patologie, infekce papilomavirem, genotyp, receptory dopaminu D2--genetika, riziko, protein-serin-threoninkinasy--genetika, polymorfismus délky restrikčních fragmentů--genetika, polymorfismus genetický, prognóza, nádory děložního čípku--genetika, genetická predispozice k nemoci, následné studie, mladiství, dospělí, ženské pohlaví, lidé, menarche, A1/A1, A1/A2, and A2/A2
Language:
English
Description:
Objectives: The aim of this study was to elucidate the role of dopamine receptor D2 / ankyrin repeat and protein kinase domain containing 1 (DRD2/ANKK1) TaqIA allelic polymorphism in the HPVinduced cervical carcinogenesis. Methods: 1. Effect on the risk of cervical precancer: After an 8year followup, out of 214 women with persisting highrisk HPV infection, 102 developed highgrade cervical dysplasia or cervical intraepithelial neoplasia (CIN) grade III, while 112 did not. The subjects were genotyped for the DRD2/ANKK1 TaqIA polymorphism by PCRRFLP, and the allelic distributions were compared between groups with and without highgrade dysplasia. 2. Prognostic value: Two hundred and thirty nine women with cervical precancer/cancer were followed for 5 years. Complete remission was achieved at 182 women. To assess the prognostic value of the TaqIA polymorphism, genotype frequencies were compared between patients reaching and not reaching complete remission. Results: The frequency of A1/A1+A1/A2 genotypes was higher among women who developed highgrade cervical dysplasia (OR: 1.87, 95% CI: 1.053.33; p=0.034) than in the other group. Occurrence of the A1 allele was more frequent among women who did not reach complete remission (OR: 2.00, 95% CI: 1.073.74; p=0.030) than in women with complete remission. Conclusions: This is the first report on the possible involvement of DRD2/ANKK1 TaqIA polymorphism in cervical carcinogenesis. The A1 allele seems to increase the risk of cervical precancer, and it may also be associated with a worse prognosis in women with HPVinduced cervical cancer. The results need further validation in largescale molecular epidemiological studies., József Cseh, Zsuzsa Orsós, Emese Pázsit, Erika Marek, András Huszár, István Ember, István Kiss, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

136. Effectivenes of spironolacton in complex therapy of rheumatoid arthritis

Creator:
Komarova, Elena and Rebrov, Borys
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, srovnávací studie, and TEXT
Subject:
revmatoidní artritida--diagnóza--etiologie--farmakoterapie, antagonisté mineralokortikoidních receptorů--terapeutické užití, spironolakton--terapeutické užití, výsledek terapie, kvalita života, cytokiny--účinky léků, kohortové studie, statistika jako téma, dospělí, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
Language:
English
Description:
Aldosterone blocker Spironolactone has anti­inflammatory, anti­proliferative and anti­oxidative effects, that is why pathogenetically it is expedient to use it in complex therapy of rheumatoid arthritis. Material and methods: 46 patients with RA took 25­50 mg/day of Spironolactone during 12 months as an addition to standard therapy, the comparison group consisted of 47 patients that got only standard therapy, all the patients were fully examined prior and post the treatment. Results: complex RA therapy leads to improved VAS, HAQ, the antioxidative potential index F; decreased blood concentrations of TNF­α, ICAM­1, FGF and VEGF in contrast to standard therapy. Complex therapy made reduced the DAS 28 more > 0.6. Conclusions: applying of Spironolactone in complex therapy of rheumatoid arthritis contributes to more pronounced improvement in indices of articular syndrome and patients life quality, reduce of anti­inflammatory, anti­proliferative and angiogenic cytokines, and more effectively reduces the activity of the disease comparing to standard therapy., Elena Komarova, Borys Rebrov, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

137. Effects of MnTnHex-2-PyP on markers of inflammation and lipid peroxidation in asthma mice model

Creator:
Veneta Shopova, Lyudmil Terziev, Violeta Dancheva, Galya Stavreva, Milena Atanasova, Angelina Stoyanova, and Tzvetan Lukanov
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
myši inbrední C57BL, modely nemocí na zvířatech, biologické markery, zánět, bronchiální astma--metabolismus, peroxidace lipidů, ovalbumin, hypertonické roztoky, bronchoalveolární lavážní tekutina, oxidační stres, časové faktory, zvířata, ženské pohlaví, and metaloporfyriny--farmakologie--metabolismus
Language:
English
Description:
Background and objective: Investigation of the effects of MnTnHex-2-PyP on some markers of inflammation and lipid peroxidation in an asthma mice model. Methods: The experiment was carried out on 24 female mice C57Bl/6, divided into four groups: group 1, controls; group 2, injected with ovalbumin (OVA); group 3, treated with MnTnHex-2-PyP and group 4, treated with OVA and MnTnHex-2-PyP. The animals from groups 1 and 3 were injected i.p. on days 0 and 14 with a 100 μl phosphate-buffered saline (PBS), and those from groups 2 and 4 were injected with a 100 μl ovalbumin solution, containing 20 μg OVA. On days 24, 25 and 26 the mice from groups 1 and 2 were inhaled with PBS for 30 min, and those from groups 2 and 4 were given a 1% ovalbumin solution. One hour before inhalation, and 12 hours later the animals from groups 1 and 2 were injected i.p. with 100 μl PBS, and those from groups 3 and 4 received a 100 μl MnTnHex-2-Pyp solution in PBS сontaining 0.05mg/kg. Results: Ovalbumin alone (group 2) increased the total cell number, total protein content, the levels of IL-4, IL-5 and 8-isoprostane in bronchoalveolar lavage. Elevations were observed in IgE level in serum, and the malone dialdehyde (MDA) content in the lung homogenate. These markers were decreased significantly in group 4 as compared to the OVA group. Conclusions: MnTnHex-2-Pyp reduces the inflammation and lipid peroxidation in Ovalbumin-induced mice asthma model, Veneta Shopova, Lyudmil Terziev, Violeta Dancheva, Galya Stavreva, Milena Atanasova, Angelina Stoyanova, Tzvetan Lukanov, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

138. Efficient collective redress mechanisms in Visegrad 4 Countries: an achievable target?

Creator:
Simon, Rita and Müllerová, Hana
Publisher:
Ústav státu a práva AV ČR, v.v.i
Format:
electronic, electronic resource, remote, bez média, online zdroj, and 1 online zdroj (280 stran).
Type:
model:monograph and TEXT
Subject:
Soukromé právo, náhrada škody, reparations, země Visegrádské skupiny, Visegrád Group countries, kolektivní odškodnění, collective redress, 347.426.6, 347.513, (4-191.2), (082), (0.034.2:08), 16, and 347
Language:
English
Description:
Rita Simon, Hana Müllerová (eds.)., Obsahuje bibliografii a bibliografické odkazy, and born digital
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

139. Ekonomická globalizace a zdraví

Creator:
Mašková, Pavla and Háva, Petr
Format:
2-10, braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, práce podpořená grantem, and TEXT
Subject:
lidé, celosvětové zdraví--dějiny--ekonomika--trendy, and zdravotní politika
Language:
Czech and English
Description:
Health performance and economic performance are interlinked. Good health is essential for economic and social development. This paper identifies and describes linkages between economic globalization and health. The aim is to analyze international professional discourse on ways how economic globaliza - tion affects health and to critical reflex development of the Czech health policy in the relation to economic globalization, financial crisis and health. The World Health Organization plays the major role in the studying the health effects resulting globalization. In the other side in the Czech Republic there is - n’t developed the discussion about social determinants of health, he - alth gap, health inequalities, health promotion. The risks of economic globalization aren’t reflected by health policy makers, Pavla Mašková, Petr Háva, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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