The entropy region is a fundamental object of study in mathematics, statistics, and information theory. On the one hand, it involves pure group theory, governing inequalities satisfied by subgroup indices, whereas on the other hand, computing network coding capacities amounts to a convex optimization over this region. In the case of four random variables, the points in the region that satisfy the Ingleton inequality (corresponding to abelian groups and to linear network codes) form a well-understood polyhedron, and so attention has turned to Ingleton-violating points in the region. How far these points extend is measured by their Ingleton score, where points with positive score are Ingleton-violating. The Four-Atom Conjecture stated that the Ingleton score cannot exceed 0.089373, but this was disproved by Matúš and Csirmaz. In this paper we employ two methods to investigate Ingleton-violating points and thereby produce the currently largest known Ingleton scores. First, we obtain many Ingleton-violating examples from non-abelian groups. Factorizability appears in many of those and is used to propose a systematic way to produce more. Second, we rephrase the problem of maximizing Ingleton score as an optimization question and introduce a new Ingleton score function, which is a limit of Ingleton scores with maximum unchanged. We use group theory to exploit symmetry in these new Ingleton score functions and the relations between them. Our approach yields some large Ingleton scores and, using this methodology, we find that there are entropic points with score 0.09250007770, currently the largest known score., Nigel Boston and Ting-Ting Nan., and Obsahuje bibliografické odkazy
Studie uvádí přehled studií zaměřených na využití expoziční terapie virtuální realitou (VRET) v rámci léčby úzkostných poruch. Autoři vymezují základní pojmy z oblasti úzkostných poruch, kyberprostoru, virtuální reality a VRET. Jejich cílem bylo zmapování výzkumných studií, jejich rozbor a interpretace výsledků. Příspěvek se zaměřuje na efekt účinnosti VRET v léčbě strachu z létání, strachu z výšek a sociální fobie. Z analýzy výzkumných studií vyplývá, že VRET má prokazatelný efekt při léčbě anxiózních poruch., The study provides an overview of articles about the use of virtual reality exposure therapy (VRET) in the treatment of anxiety disorders. Authors defined the basic concepts as anxiety disorders, cyberspace, virtual reality and VRET. The aim of article is to map the specific research studies, their analysis and interpretation. Authors focused on the effect size of VRET in the fear of flying, acrophobia and social phobia treatment. They close that VRET has demonstrable effect on effectiveness of anxious disorders treatment., Jan Šmahaj, Roman Procházka., and Obsahuje seznam literatury
Visfatin is a multi-functional molecule that can act intracellularly and extracellularly as an adipokine, cytokine and enzyme. One of the main questions concerning visfatin is the mechanism of its secretion; whether, how and from which cells visfatin is released. The objective of this in vitro study was to observe the active secretion of visfatin from 3T3-L1 preadipocytes and adipocytes, HepG2 hepatocytes, U-937, THP-1 and HL-60 monocytes and macrophages. The amount of visfatin in media and cell lysate was always related to the intracellular enzyme, glyceraldehyde-3- phosphate dehydrogenase (GAPDH), to exclude the passive release of visfatin. Visfatin was not found in media of 3T3-L1 preadipocytes. In media of 3T3-L1 adipocytes and HepG2 hepatocytes, the ratio of visfatin to the amount of GAPDH was identical to cell lysates. Hence, it is likely that these cells do not actively secrete visfatin in a significant manner. However, we found that significant producers of visfatin are differentiated macrophages and that the amount of secreted visfatin depends on used cell line and it is affected by the mode of differentiation. Results show that 3T3-L1 adipocytes and HepG2 hepatocytes released visfatin only passively during the cell death. U-937 macrophages secrete visfatin in the greatest level from all of the tested cell lines., P. Svoboda, E. Křížová, K. Čeňková, K. Vápenková, J. Zídková, V. Zídek, V. Škop., and Obsahuje bibliografii
V dějinách idejí se vitalismu dostalo různých definic a různé postavy byly označeny za vitalisty. Když se soustředíme na 17. století, zjistíme, že badatelé identifikovali jako vitalisty autory, kteří zastávají názory, jež jsou v diametrálním protikladu. Stručně představím názory dualistických vitalistů (Henry More, Ralph Cudworth a Nehemiah Grew) a monistických vitalistů (Francis Glisson, Margaret Cavendishová, Anne Conwayová), a filosofické a teologické uvažování, které formovalo jejich myšelní. Ve všech těchto různých podobách vitalismu se nacházejí identifikovatelné společné motivy: bytostná neredukovatelnost života (považovaná za vlastnost buď nehmotného ducha nebo samotného hmoty) a univerzalita života (sahající daleko za "organickou" oblast přírody až "anorganické")., Vitalism has been given different definitions and diverse figures have been labelled as vitalists throughout the history of ideas. Concentrating on the seventeenth century, we find that scholars identify as vitalists authors who endorse notions that are in diametrical opposition with each other. I briefly present the ideas of dualist vitalists (Henry More, Ralph Cudworth and Nehemiah Grew) and monist vitalists (Francis Glisson, Margaret Cavendish and Anne Conway) and the philosophical and theological considerations informing their thought. In all these varied forms of vitalism the identifiable common motives are the essential irreducibility of life (regarded as a property of either an immaterial spirit or matter itself) and the universality of life (extending well beyond the “organic” realm of nature, incorporating the “inorganic”)., and Veronika Szántó.
In this review we summarize recent opinions on the possible role of vitamin D in the risk of thyroid diseases development. It may be concluded from the available data that vitamin D deficiency, particularly levels below 12.5 ng/ml should be considered as an additional, but important risk factor for development of thyroid autoimmunity, both chronic autoimmune thyroiditis and Graves´ disease. A higher risk of Graves´ disease development is also associated with several polymorphisms in the gene encoding for vitamin D binding protein and for the specific receptor of active form of vitamin D - 1,25-(OH)2D3 in the respective target cells. Important for development of thyroid cancer appeared polymorphisms of genes encoding for vitamin D receptors and of genes encoding for the participating hydroxylating enzymes in thyroid tissue, leading to a diminished local 1,25-(OH)2D3 formation capacity with following alteration of antiproliferatory, antiapoptotic and prodifferentiating efficacy of the latter. Whether supplementation with high doses of vitamin D or its analogues possesses preventive or therapeutic effect is an object of intensive studies., K. Vondra, L. Stárka, R. Hampl., and Obsahuje bibliografii
Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors, but there have been conflicting results in subjects with anxiety disorders. In the present cross-sectional study, levels of calcidiol were determined in groups of depressive men and women and in men and women with anxiety disorders and compared with age matched controls. Significantly lower levels of calcidiol were found in men and women with depression as well as in age matched patients with anxiety disorders., M. Bičíková, M. Dušková, J. Vítků, B. Kalvachová, D. Řípová, P. Mohr, L. Stárka., and Obsahuje bibliografii
In women with chronic autoimmune thyroiditis and vitamin D deficiency we have found reference levels of relevant metabolichormonal parameters except for parathormone and total calcium. Three months supplementation with vitamin D (4300 IU/day, cholekalciferol) did not lead to significant changes of investigated hormonal parameters, while the levels of parathormone and calcium reached normal levels. However, a correlation analysis revealed marked changes in mutual relations. First, an inverse correlation of vitamin D with parathormone, insulin secretion (C peptide, insulin) and its efficiency (HOMA IR) disappeared. Relationships of vitamin D to hepatic insulin resistance (insulin/C peptide), to DHEA (both negative), and to DHEAS/DHEA ratio (positive) were newly found. Second, a positive correlation of CRP with insulin secretion remained, while its relation to insulin efficiency (HOMA IR, insulin/ C peptide) was newly observed. Analogical positive correlations appeared also among anti TPO and insulinemia, insulin/C peptide, HOMA IR, and anti Tg to C peptide. A relationship of the CRP with anti TPO became significant (+). Third, out of glucose metabolism parameters only insulin/C peptide and glycemia did not correlate with vitamin D during its deficiency, while after supplementation insulin/ C peptide alone correlated positively with both DHEAS and DHEA, and negatively with vitamin D., K. Vondra, R. Bílek, P. Matucha, M. Salátová, M. Vosátková, L. Stárka, R. Hampl., and Obsahuje bibliografii