Karst landforms can result from a single stage process in which chemical dissolution and mechanical erosion proceed simultaneously or from a two stage process in which chemical dissolution precedes mechanical erosion. During the second of these processes, chemical dissolution leads to the creation of karst features hosting a residual weathering product, here referred to as alterite. An example of one such feature is the enclosed mass of altered rock at Červený Quarry near Klukovice which represents one of the richest localities for exceptionally preserved echinoderm ossicles in the Prague Synform. In this study the processes responsible for the formation of this feature have been investigated. Nineteen samples were obtained from the bioclastic Slivenec Limestone and from these it has been possible to calculate the carbonate volume content, which defines the weathering intensity, and the carbonate rock weathering index, which defines the weathering state. The results demonstrate that carbonate dissolution has not been accompanied by gravitational compaction or the incorporation of mineral inputs. Thin sections analysed under polarised light and under cathodoluminescence emphasise heterogeneous dolomitisation of the limestone. As the weathering grade intensifies, empty rhomboidal pores become increasingly common until, ultimately, the rhomboidal forms are lost due to corrosion and enlargement. In contrast it is rare to find evidence of calcite dissolution and, therefore, the altered mass still hosts almost all of its post dolomitisation micrite, sparite, and bioclasts. Negligible calcite dissolution helps to explain the exceptional nature of the fossil preservation at the site while the dolomite dissolution accounts for the ease with which it is possible to extract the fossils. Further research should focus on better understanding the role of dolomite dissolution in the formation of other important palaeontological localities in the Prague Synform., Matt Rowberry, Caroline Dubois, Olivier Kaufmann, Jean-Marc Baele and Jan Blahůt., and Obsahuje bibliografii
Když benevolence zraňuje ženy a favorizuje muže: účinky ambivalentního sexismu na aspirace na vůdcovství Literatura o ambivalentním sexismu ukázala, že benevolence vůči ženám může být dokonce škodlivější než otevřené nepřátelství, protože není jasně rozpoznatelná jako druh předsudku, a tak je obtížnější s ní bojovat. Podobně benevolence vůči mužům predikuje vnímanou oprávněnost genderové hierarchie. Účinek sexismu na mužské a ženské aspirace na vůdcovství však ještě nebyl zkoumán. Účastníci studie (N = 101) byli poučeni o sexismu (hostilním vs. benevolentním) vůči vlastnímu pohlaví. Výsledky ukázaly, že benevolence podporuje možnost udržení vůdcovské role u mužů, ale odrazuje ženy od vůdcovských pozic. Ženy dokonce považují benevolentní a hostilní postoje vůči ženám za podobné předsudky. Muži naopak vymezují hostilní sexismus vůči mužům jako více předsudečný než benevolentní postoje., Literature on ambivalent sexism has shown that benevolence toward women can be even more pernicious than explicit hostility because it is not clearly recognizable as a form of prejudice and thus it is more difficult to combat. Similarly, benevolence toward men predicts the perceived legitimacy of gender hierarchy. However, the effects of sexism on men’s and women’s leadership aspiration have not been studied yet. In the present study participants (N = 101) were primed with sexism (Hostile vs. Benevolent) toward their own gender. Results showed that benevolence fosters the possibility of holding a leadership role for men, but harms women from leader positions. Moreover, women consider benevolent and hostile attitudes toward women as similarly prejudiced. On the contrary, men define hostile sexism toward men as more prejudiced than benevolent attitudes., Chiara Rollero, Angela Fed., and Obsahuje seznam literatury
The aim of the present study was to introduce methods for exome sequencing of two ATP-binding cassette (ABC) transporters ABCC8 and ABCD2 recently suggested to play a putative role in breast cancer progression and prognosis of patients. We performed next generation sequencing targeted at analysis of all exons in ABCC8 and ABCD2 genes and surrounding noncoding sequences in blood DNA samples from 24 patients with breast cancer. The revealed alterations were characterized by in silico tools. We then compared the most frequent functionally relevant polymorphism rs757110 in ABCC8 with clinical data of patients. In total, the study identified 113 genetic alterations (>70 % novel ones) in both genes. Of these alterations, 83 were noncoding, 13 synonymous, 10 frameshifts and 7 were missense alterations. Four in silico programs predicted pathogenicity of two polymorphisms and four newly identified alterations. Rs757110 polymorphism in ABCC8 did not significantly associate with clinical data of the patients. In conclusion, exome sequencing identified several functionally relevant alterations in ABCC8 and ABCD2 genes that may further be used for a larger follow-up study aiming to assess their clinical significance., P. Soucek, V. Hlavac, K. Elsnerova, R. Vaclavikova, R. Kozevnikovova, K. Raus., and Obsahuje bibliografii