Number of results to display per page
Search Results
4172. Děčínský jinan dvoulaločný
- Creator:
- Pelcman, Václav
- Format:
- Type:
- article, zprávy, reports, model:article, and TEXT
- Subject:
- Botanika, botanika, jinan dvoulaločný, měření, botany, Ginkgo biloba, measurement, Děčín (Česko), Děčín (Czechia), 2, and 58
- Language:
- Czech
- Description:
- Václav Pelcman.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4173. Decomposing Stimulus Complexes and Dissecting Art: A Theory of Evaluation
- Creator:
- Huston, J. P.
- Format:
- print, bez média, and svazek
- Type:
- article, studie, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Model, Complex stimuli, Art, 14, and 612
- Language:
- English
- Description:
- A theoretical model is presented, which attempts to account for the evaluation of complex stimuli in terms of their constituent elements that are relevant to the intent of the assessment. The subjective evaluation of a compound stimulus is postulated to be a function of the number, weight and integrity of critical components, or sub-qualities, and their interactions. The model has application to the evaluation of any stimulus complex including works of “art”. For illustrative purpose, it will here be applied to the analysis of pictorial works of art., J. P. Huston., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4174. Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma
- Creator:
- Radovan Bílek, Tomáš Zelinka, Petr Vlček, Jaroslava Dušková, David Michalský, Novák, K., Jiří Bešťák, and Jiří Widimský
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, moč, chromatografie, feochromocytomy, paragangliomy, urine, chromatography, pheochromocytoms, paraganglioms, deconjugated metanephrine, deconjugated normetanephrine, deconjugated 3-methoxytyramine, electrochemical detection, 14, and 612
- Language:
- English
- Description:
- This work discusses the clinical performance of deconjugated metanephrine (MN), normetanephrine (NMN) and 3-methoxytyramine (3MT) determined in the basal first morning urine using a chromatographic method with electrochemical detection for the clinical diagnosis of pheochromocytoma (PHEO) and paraganglioma (PGL). Urine samples were collected from 44 patients (36 with PHEO, 8 with PGL) aged 54+/-17 (20-78) years (22 females, 22 males). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery. The control group consisted of 34 PHEO/PGL patients more than 4 months after adrenal gland surgery. All subjects in the control group were without a diagnosis of PHEO or PGL. Clinical sensitivity was 55 % for MN, 64 % for NMN, 80 % for combination of both MN and NMN, and only 23 % for 3TM. Clinical specificity calculated from the control group was 93 % for MN, 95 % for NMN, 95 % for the combination MN and NMN, and 97 % for 3TM. Cut-off values for deconjugated metanephrines in the basal urine were 310 (MN), 690 (NMN) and 250 μg/l (3MT). Chromatographic determination of deconjugated urinary metanephrines, which is simple without the necessity of special laboratory material, can serve for the screening of PHEO or PGL patients. Urine NMN and 3MT exerts an association to malignity, and all markers are associated with tumor mass. However, the principal laboratory diagnosis of PHEO or PGL must be based on plasma-free metanephrines and plasma chromogranin A with better performance in the laboratory diagnosis of PHEO or PGL., R. Bílek, T. Zelinka, P. Vlček, J. Dušková, D. Michalský, K. novák, J. Bešťák, J. Widimský Jr., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4175. Decrease in serum interleukin-21 levels is associated with disease activity improvement in patients with recent-onset rheumatoid arthritis
- Creator:
- Sglunda, O., Mann, H. F., Hana Hulejová, Pecha, O., Lenka Pleštilová, Olga Růžičková, Fojtíková, M., Olga Šléglová, Šárka Forejtová, Karel Pavelka, Jiří Vencovský, and Ladislav Šenolt
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, revmatoidní artritida, rheumatoid arthritis, interleukin-21, disease activity, remission, 14, and 612
- Language:
- English
- Description:
- Interleukin-21 (IL-21) plays an important role in the pathogenesis of rheumatoid arthritis (RA). The aim of our study was to assess serum levels of IL-21 in patients with recent-onset RA in relation to disease activity and response to treatment. We analyzed serum levels of IL-21 in 51 RA patients, both before and 12 weeks after the initiation of treatment and in 36 healthy individuals. Disease activity was assessed at baseline and at weeks 12 and 24 using the Disease Activity Score for 28 joints, serum levels of C-reactive protein, and the total swollen joint count. We found that IL-21 levels were not increased in patients with recent-onset RA compared with healthy controls, but they had significantly decreased from baseline to week 12 during treatment. Baseline levels of IL-21 significantly correlated with measures of disease activity (p<0.02 for all). Although IL-21 levels did not predict achievement of remission, decrease in IL-21 levels correlated with improvement in disease activity after 12 weeks (p<0.02) and also after 24 weeks (p<0.04) of treatment. Our data suggest that circulating IL-21 levels may serve as a biomarker of disease activity and better outcome in early phase of RA., O. Sglunda, H. F. Mann, H. Hulejová, O. Pecha, L. Pleštilová, O. Růžičková, M. Fojtíková, O. Šléglová, Š. Forejtová, K. Pavelka, J. Vencovský, L. Šenolt., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4176. Decreased level of endogenous secretory receptor for advanced glycation end-products in diabetes with concomitant hyperlipidemia
- Creator:
- Turk, Z., Ljubić, S., and Boras, J.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, hyperlipidémie, hyperlipidemia, advanced glycation pathway, type 2 diabetes, endogenous secretory receptor for AGE, AGE-to-esRAGE ratio, 14, and 612
- Language:
- English
- Description:
- Endogenous secretory receptor (esRAGE) for advanced glycation end-product (AGE) acts as decoy for AGEs. The AGE-to-esRAGE ratio was hypothesized to be implicated in diabetic vasculopathy. We investigated an associatio n of esRAGE and methylglyoxal- adducts serum level, as well as AGE-to-esRAGE ratio in subpopulation of diabetic patients with or without concomitant hyperlipidemia and macrovascular disease in history. In diabetes with concomitant hyperlipidemia esRAGE was significantly decreased compared to hyperlipidemia with normal glucose metabolism (0.306±0.2 vs. 0.367± 0.1; p=0.019) or diabetes alone (0.306±0.2 vs. 0.404±0.1; p = 0.004). High AGE/esRAGE ratio, found in diabetic patients with hyperlipidemia, pointed to increased production of AGEs and low expression of esRAGE. In multivariable analysis adjusted for several confounding factors, increased AGE/esRAGE ratio was re cognized as a high risk for vascular disease outcomes., Z. Turk, S. Ljubić, J. Boras., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4177. Decreasing leaf water content induces Crassulacean acíd metabolism in well-irrigated Mesembryanthemum crystallinum
- Creator:
- Piepenbrock, M., von Albert, C., and Schmitt, J.M.
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Multiple languages
- Description:
- The induction of Crassulacean acid metabolism (CAM) characterized by day/night acid fluctuation was measured in leaves from well-watered plants of Mesembryanthemum crystallinum grown in pots of four different volumes (160, 740, 2 600, and 6 500 cm^). CAM induction was dependent on soil volume: ťhe larger the pot, the later the induction took plače. Induction started when shoot water content fell to below 3 000 % of dry mass. For plants grown in the smaller pots (160-2 600 cm^) induction was linearly correlated with decreasing leaf water content. In contiast, induction was neither correlated with age nor with developmental stage of the plants. For plants grown in the largest pots leaf water content was not decreased and CAM was not induced up to week 10. Thus CAM induction is controlled environmentally rather than developmentally.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4178. Dědické strategie a předávání gruntu ve vztahu k příbuzenství a genderu: případ bulharských čechů, 1990-1950
- Creator:
- Budilová, Lenka J.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Demografie. Populace, rodinné vztahy, gender, family relations, Vojvodovo (Bulharsko), Bulgarian Czechs, heritage strategies, 18, and 314
- Language:
- Czech
- Description:
- This text focuses on the community of portestant Bulgarian Czechs, who lived in the years 1900-1950 in two villages Vojvodovo (north-western Bulgaria) and Belinci (eastern Bulgaria). Within the frame of this community the inheritance practices and strategies of the passing of family possession between generations are analysed in relation to family relations and gender. Attention is dedicated expecially to the preponderant ideology of dividable property, the practice of transfer of the property inter vivos, the favouring of male heirs and the youngest son as inheritor of the homestead of parents. These characteristics are further analysed with respect to the family strategies, family relations and gender (im) balance within the frame of this community. The practice of heritage is analysed also with respect to the predominant subsistence strategy (agriculture) and the efforts of the parents to enable the children to keep on in this subsistence that ultimately led to the parcelling out of the land and to repeated migrations for land., Lenka J. Budilová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4179. Dědičné ulceromutilující senzitivní neuropatie – klinická, elektrofyziologická a molekulárně genetická studie tří rodin
- Creator:
- Šafka-Brožková, Dana, Mazanec, Radim, Böhm, Jiří, Vyšata, Oldřich, Auer-Grumbach, M., Windpassinger, Ch, Neupauerová, Jana, Baránková, Lucia, Nevšímalová, Soňa, and Seeman, Pavel
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- dědičné senzorické a autonomní neuropatie--diagnóza--genetika--patofyziologie, rodokmen, poruchy senzitivity--genetika, čití, cítění--genetika, serin-C-palmitoyltransferasa--genetika, proteiny - podjednotky--genetika, mutace--genetika, sfingolipidy--biosyntéza--genetika, rab proteiny vázající GTP--genetika, genetické testování, končetiny, nemoci periferního nervového systému--genetika, haplotypy, amputace, poranění nohy--genetika, serin, ženské pohlaví, lidé, mužské pohlaví, and rodina
- Language:
- Czech and English
- Description:
- Cíl: Cílem práce je charakterizovat klinické a elektrofyziologické nálezy dvou typů ulceromutilující dědičné neuropatie CMT2B a HSN1 u tří českých rodin s molekulárně geneticky objasněnou příčinou. Soubor: Popisujeme tři rodiny s dědičnou senzitivní neuropatií s celkem 16 postiženými. Metodika: Na základě neurologického a elektromyografického vyšetření, výskytu podobných obtíží u příbuzných byla stanovena diagnóza senzitivní, převážně axonální neuropatie. Následně bylo provedeno sekvenování genů SPTLC1 a RAB7 v rodinách A, B, C a u dalších 24 nepříbuzných pacientů s klinickým podezřením na dědičnou senzitivní neuropatii. Výsledky: V rodině B byla nálezem mutace p.C133Y v SPTLC1 genu prokázána hereditární senzitivní neuropatie typ 1 (HSN1). V rodinách A a C byla nálezem mutací p.L129F a p.V162M v genu RAB7 prokázána choroba Charcot‑Marie‑Tooth typ 2B (CMT2B). Všechny tři mutace již byly dříve popsány a fenotyp odpovídá popisu pacientů z jiných zemí. DNA vyšetření dalších 24 nepříbuzných pacientů však příčinu onemocnění neobjasnilo. Závěr: Ulceromutilující dědičné neuropatie CMT2B a HSN1 jsou v české populaci, podobně jako v jiných zemích vzácné, ale klinické projevy jsou jasně poznatelné, pokud jsou zohledněny a správně získány genealogické údaje – rodinná anamnéza. Tyto tři popsané rodiny jsou dosud jediné známé v ČR s objasněnou příčinou dědičné senzitivní neuropatie v důsledku mutací v RAB7 a SPTLC1. Objasnění příčiny ulceromutilující senzitivní neuropatie má význam nejen pro upřesnění genetické a klinické prognózy a pro cílenou genetickou prevenci, ale u pacientů s mutacemi v SPTLC1 genu možná i pro cílenou terapii se substitucí L‑serinem, která bude testována v klinické studii (Boston, USA), Aim: The goal was to clinically and electrophysiologically characterize two types of ulceromutilating hereditary neuropathy CMT2B and HSN1 in three Czech families where molecular genetic cause was confirmed. Patients: We describe three families, overall 16 affected patients, with hereditary sensory neuropathy. Methods: The diagnosis of sensory, predominantly axonal neuropathy was done on the basis of neurological and electrophysiological examination. Sequencing of the SPTLC1 and RAB7 genes was done in families A, B, C and 24 unrelated patients with clinical suspicion for HSN. Results: Hereditary sensory neuropathy type 1 (HSN1) caused by the p.C133Y mutation in the SPTLC1 gene was confirmed in family B and the Charcot-Marie-Tooth type 2B (CMT2B) caused by p.L129F and p.V162M mutations in the RAB7 gene was confirmed in families A and C. All three mutations have been previously described. DNA examination of 24 unrelated patients did not reveal the cause of their disease. Conclusion: As in other countries, ulceromutilating hereditary neuropathies CMT2B and HSN1 are rare in the Czech population. However, clinical manifestations are clearly recognizable if correctly obtained genealogical data – family history – is properly taken into account. The three families described here are the only known families with hereditary neuropathies caused by mutations in RAB7 and SPTLC1 in the Czech Republic. Clarification of the cause of ulceromutilating sensory neuropathy is crucial for genetic and clinical prognosis, including targeted genetic prevention, but possibly also for an L-serin therapy in SPTLC1 mutation patients to be tested in a clinical study (Boston, USA)., and D. Šafka Brožková, R. Mazanec, J. Böhm, O. Vyšata, M. Auer-Grumbach, Ch. Windpassinger, J. Neupauerová, L. Baránková, S. Nevšímalová, P. Seeman
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4180. Dědictví revoluce 1848-1849
- Creator:
- Milan Hlavačka
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Dějiny Česka a Slovenska, 1848-1849, politické dějiny, monarchie, ústava, political history, monarchy, constitution, 8, and 94(437)
- Language:
- Czech
- Description:
- From March 1848 through July 1849, the Habsburg Austrian Empire was threatened by revolutionary movements. Much of the revolutionary activity was of a nationalist character: the empire, ruled from Vienna, included Austrian Germans, Hungarians, Slovenes, Poles, Czechs, Slovaks, Ruthenians, Romanians, Serbs, Italians, and Croats, all of whom attempted in the course of the revolution to either achieve autonomy, independence, or even hegemony over other nationalities. and Milan Hlavačka.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public