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22. „Liver first approach“ u synchronních metastáz kolorektálního karcinomu: Předběžné výsledky nerandomizované studie
- Creator:
- Pudil, Jiří, Batko, Stanislav, Menclová, Kateřina, Blaha, Milan, and Ryska, Miroslav
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- nádory jater--chirurgie--sekundární, kolorektální nádory--komplikace, metastázy nádorů--terapie, výsledky a postupy - zhodnocení (zdravotní péče), chemoterapie adjuvantní, statistika jako téma, dospělí, staří, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
- Language:
- Czech and English
- Description:
- Úvod: U 60 % nemocných s kolorektálním karcinomem jsou diagnostikovány jaterní metastázy (JMKRK), ať už v době stanovení diagnózy, nebo v průběhu léčby. Chirurgická léčba je jedinou potenciálně kurabilní metodou s pětiletým přežíváním dosahujícím cca 50 %. Jaterní resekci však podstoupí méně než 20 % pacientů s JMKRK. Společnou snahou onkologů a chirurgů je navýšit počet resekovaných pacientů. Jedním z postupů, jak navýšit resekabilitu JMKRK, je „liver first approach“ (LFA). Autoři prezentují vlastní předběžné výsledky této metody. Metody: Do multicentrického grantu IGA MZ NT 13660 – Hodnocení kvality multimodální péče u nemocných s jaterními metastázami kolorektálního karcinomu – bylo od září 2012 do ledna 2015 zařazeno v ÚVN 102 pacientů. LFA jsme použili u 12 pacientů (12 %). Po příznivé léčebné odpovědi neoadjuvantní systémové léčby jsme pacienty indikovali k resekci jater. U 11 pacientů se jednalo o mnohočetné (>4 meta) bilobární postižení. V jednom případě se jednalo o objemnou solitární metastázu pravého jaterního laloku. Primární tumor byl u 9 nemocných v rektu, u 3 v oblasti rektosigmatu, 3 pacienti měli derivační kolostomii, ostatní byli bez poruchy pasáže. Výsledky: U 11 pacientů jsme provedli R0 resekci jaterních metastáz, 3x jsme indikovali dvoufázovou hepatektomii s portální embolizací (PVE), 1x jsme pro progresi po PVE ustoupili od 2. fáze). Velkou resekci jsme provedli 7x, neanatomickou resekci včetně RFA 11x (6x v kombinaci s velkou resekcí). Perioperační mortalita byla nulová, morbidita 33 % (Dindo-Clavien >2). 10 pacientů absolvovalo adjuvantní chemoterapii, 7 z nich včetně radioterapie malé pánve pro lokálně pokročilý tumor rekta. U 7 pacientů (58 %) jsme doplnili resekci primárního tumoru. V současné době zemřeli na progresi onemocnění 2 pacienti (17 %), progresi onemocnění jsme zaznamenali u 6 pacientů (50 %). Závěr: LFA považujeme za vhodný především u pacientů s generalizovaným tumorem rekta, kdy lze po resekci jater adjuvantní systémovou léčbu kombinovat s radioterapií malé pánve. Otázkou zůstává načasování operace primárního tumoru, kdy je nutné vyloučit recidivu jaterních metastáz, která se objevuje u více než 50 % pacientů. Profit LFA musí být prokázán randomizovanými studiemi., Introduction: Liver metastases are diagnosed in 60% of patients with colorectal cancer, both at the time of diagnosis or later in the course of their management. Surgical treatment is the sole potentially curable method with 5–year overall survival of approximately 50%. However, only less than 20% of patients underwent liver resection. A joint effort of medical oncologists and surgeons is to increase the numbers of resected patients. The “liver first approach” (LFA) is one of approaches aimed at increasing resecability. The authors present their preliminary results using this method. Methods: 102 patients were included in the multicentre study supported by the grant IGA NT 13660 − Evaluation of quality of multimodal treatment for patients with colorectal cancer liver metastases – conducted at the Central Military Hospital between September 2012 and January 2015. We used LFA in 12 patients (12%). Patients were indicated for liver resection based on good response to neoadjuvant systemic therapy. Multiple bilobar liver involvement (>4 metastases) was present in 11 cases and one large solitary metastasis in the right liver lobe in one case. The primary tumor was located in the rectum in 9 patients, in the rectosigmoid in 3 patients; 3 patients had a colostomy. Others showed no signs of bowel obstruction. Results: We have performed R0 resections in 11 cases, and two-stage hepatectomy with portal vein embolisation was indicated 3 times (in one case we did not finish the second stage due to quick progression after PVE). We performed major resections 7 times, along with sever extraanatomic resections, incl. 11 RFA (6 times in combination with major resections). Perioperative mortality was 0%, morbidity 33% (Dindo-Clavien >2). Ten patients underwent adjuvant chemotherapy, in 7 cases including radiotherapy of the small pelvis due to a local advanced primary tumor. Resection of the primary tumor was done in 7 patients (58%). Two patients died recently because of disease progression (17%); progression was observed in 6 patients (50%). Conclusion: We deem the LFA suitable especially for patients with metastatic rectal tumors where adjuvant systemic therapy can be combined with radiotherapy. The timing of the resection of the primary tumor still remains a question: it is necessary to rule out potential recurrence of liver metastases, which affected more than 50% of the patients. The benefit of LFA must be confimed by randomised studies., and J. Pudil, S. Batko, K. Menclová, M. Bláha, M. Ryska
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
23. "Mise" s cílem ITER
- Creator:
- Marina Hužvárová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, ITER (projekt), termojaderná syntéza, thermonuclear fusion, 12, and 00
- Language:
- Czech
- Description:
- Marina Hužvárová.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
24. "Needless to say my proposal was turned down." The early days of commercial citation indexing, an "error-making" (Popper) activity and its repercussions till today
- Creator:
- Tüür-Fröhlich, Terje
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- věda, evaluace, scientometrie, science, evaluation, scientometrics, žebříčky hodnocení, chyby, kritická studia vědy, rankings, errors, critical science studies, 12, and 00
- Language:
- Czech
- Description:
- Today university rankings and performance rankings (ot en based on JIFs, h-indexes) are believed to be indispensable to assure scientii c “quality”. Most of these performance rankings employ citation data provided by h omson Reuters. TR’s current inl uence on funding decisions, individual careers, institutions, disciplines and countries is immense and ambivalent. h ere is increasing resistance against “impactitis” and “evaluitis”. Usually overseen: Trivial errors in TR’s citation indexes (SCI, SSCI, AHCI) produce severe non-trivial ef ects: h eir victims are authors, institutions, journals with names beyond the ASCIIcode and scholars of humanities and social sciences. Based on the Joshua Lederberg Papers I claim: To overcome severe resistance Eugene Gari eld and Joshua Lederberg had to foster overoptimistic attitudes and to downplay the severe problems connected to global and multidisciplinary citation indexing. h e dii culties to handle dif erent formats of references and footnotes, non- Anglo-American names, and of publications in non-English languages were known to the pioneers of citation indexing., Dnešní žebříčky univerzit a výkonnosti (často založené na JIF a h-indexech) jsou považovány za nepostradatelné pro zajištění vědecké „kvality“. Většina z těchto žebříčku produktivity využívá citační údaje poskytnuté h omson Reuters. Současný vliv TR na rozhodování o i nancování, na individuální kariéry, instituce, obory a země je ohromný a ambivalentní. Odpor vuči „impaktitidě“ a „evaluatitidě“ se zvyšuje. Obvykle je přehlížena skutečnost, že triviální chyby v citačních indexech TR (SCI, SSCI, AHCI) mají závažné, netriviální následky: jejich obětmi jsou autoři, instituce, časopisy vymykající se ASCII-kódu a akademici v humanitních a sociálních vědách. Na základě rozboru Joshua Lederberg Papers tvrdím, že aby překonali tvrdý odpor, Eugene Gari eld a Joshua Lederberg museli protěžovat přehnaně optimistické postoje a zlehčovat vážné problémy spojené s globálními a multidisciplinárními citačními indexy. Obtíže plynoucí z ruzných formátu odkazu a poznámek, jiných než anglo-amerických jmen a publikací v jiných jazycích než v angličtině byly známy již prukopníkum citačních indexu., and Terje Tüür-Fröhlich.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
25. "Nekupujete si lásku, kupujete si službu": (re)konstrukce péče o děti v prostředí agentur na hlídání
- Creator:
- Souralová, Adéla
- Format:
- Type:
- model:article and TEXT
- Subject:
- péče o dítě, chůvy, child care, babysitters, placement agencies, nannies, 18, and 316
- Language:
- Czech
- Description:
- During the last couple of decades, paid childcare has become one of the central issues of feminist research. Agencies mediating childcare are a relatively new actor in childcare arrangements in the Czech Republic. This article argues that these agencies do not fill a gap in the market by offering childcare. Far from providing simple supply that reacts to a market demand, the agencies create the demand for specific care. Drawing upon qualitative research conducted with owners of these agencies, the text looks into the ways in which childcare is constructed. The issues of qualified, specialized, and professionalized care are discussed. The article aims to show that childcare in the agencies is deconstructed as a natural female activity and is reconstructed as a gendered activity requiring particular skills that are subjected to professional screening., Adéla Souralová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
26. „O podivuhodném promíchání pražských mnichů a dívek”: Bohemikální a lucemburské pasáže Georgese Chastelaina z let 1455-1459 jako historiografický a metodologický problém
- Creator:
- Martin Nejedlý
- Format:
- Type:
- model:article and TEXT
- Subject:
- burgundský historiograf, Chastelain, Georges, ca 1415-1475, z Arku, svatá, Jana, 1412-1431, 15. století, historiografie, metodologie, středověk, husitství, bohemika, historiography, methodology, middle ages, Hussitism, Bohemistics (sources), Burgundsko (Francie : kraj), Burgundy (France), 8, and 930
- Language:
- Czech
- Description:
- The official Burgundian historiographer Georges Chastellain (perhaps 1415-1475) left an extensive work of various genres behind. We also find in the Chronicle noteworthy Bohemicalia and Luxemburg passages, concerning particularly the origin of Hussitism. Chastellain saw the roots of this revolution in the lascivious alliance of Prague girls and the monks of one monastery there. To be able to sleep with their lovers, the girls cut their hair and wore monk´s cowls. It was the beginning of absolute chaos and reversal of the established hierarchies in Bohemia. We do not know the direct source of the author´s inspiration, but ideologically the story is close to a number of works of anti-Hussite propaganda, emphasising the destructive role of women in the revolution. It is also not an accident that Chastellain included the chapter on the Prague girls just before the narrative on Joan of Arc, for whom as an author from Burgundy he did not sympathize. Also she changed into men´s clothing and her behaviour led to wars and chaos according to the author. The parallel was to be obvious. At the time when he wrote the passage on Hussitism, Georges Chastellain also considered the mission of historians and their place in the period society. He ascribed a place to them almost on the same level as aristocrats. It was a parallel: like aristocrats use the sword, the tongue must serve men of the quill for the elimination of the injustice of this world. and Martin Nejedlý.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
27. "Občanská společnost na papíře" aneb "Konstruování, kodifikace a realizace konceptu občanské společnosti v habsburské monarchii"
- Creator:
- Hlavačka, Milan and Tinková, Daniela
- Format:
- print, text, regular print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- konference, právo, conferences, law, 8, and 94(437)
- Language:
- Czech
- Description:
- Milan Hlavačka a Daniela Tinková.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
28. "Obecný lid nejvíc ziskem k činům se popuzuje": záchrany lidí před utonutím v Čechách na konci 18. století
- Creator:
- Hudeček, Ondřej
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- utonutí, drowning, Česko, Czechia, zdravotní policie, remunerace, drowning people, remuneration, medical police, 8, and 94(437)
- Language:
- Czech and English
- Description:
- This article examines the administration of rescue operations to save people from drowning and the distribution of rewards to rescuers in Bohemia during the 1780s and 1790s. Based on documented interrogations and official records, the article looks at the investigatory process, the conditions rescuers had to fulfil in order to apply for a reward from the Bohemian Gubernium, and the role of other actors in this process, such as witnesses and doctors. The study departs from the concept of biopolitics developed by French philosopher Michel Foucault and shows how the state authorities tried to foster mutual solidarity among town dwellers. While Enlightenment thinkers continued to stress the role of "love for human beings" (Menschenliebe), i.e. universal interpersonal solidarity, the elites held the view that the biggest motivation for anyone to save a person from drowning was monetary reward. The aim of the enlighteners, however, was to encourage people to embrace the ideal of "Menschenliebe" and to fully identify with it - hence their emphasis on cases of selfless acts, especially in newspapers and popular literature. Besides that, the article analyses the trend towards the medicalization of society in the Enlightenment period and changes in attitudes to death., Ondřej Hudeček., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29. "Postdokovat po světě": genderové politiky akademické mobility
- Creator:
- Alice Červinková
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- gender, ženy ve vědě, vědkyně, pracovní mobilita, rozvoj kariéry, women in science, women scientists, labor mobility, career development, akademická mobilita, care, academic mobility, 18, and 316.4/.7
- Language:
- Czech
- Description:
- The mobility of scientists that is the subject of this article is part of the broad scale of flows of people, objects, and knowledge in the contemporary world. These flows occur in multiple ways: from relocation and settlement in another country, to everyday pendulating mobility back and forth across boarders. In this article, the author is concerned with academic mobility and particularly mobility tied to long-term post-doctoral fellowships. She sets out to explore the gender dimension of long-term academic mobility and observe how scientists organise their professional and personal lives around movement between academic institutions. She argues that mobility at this stage of the academic trajectory involves the production of new (re)configurations of partnerships, while at the same time the fact of being in a partnership is constitutive for establishing an academic career., Alice Červinková., Téma: Feministická reflexe globalizace, Obsahuje bibliografii, and Anglické resumé
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
30. „Pražská škola kritické teorie“ nastiňuje vize budoucího zkoumání společnosti: Hrubec, M. a kol. Kritická teorie společnosti. Český kontext
- Creator:
- Radka Janebová
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- sociologie, kritická teorie, společnost, 18, and 316
- Language:
- Czech
- Description:
- [autor recenze] Radka Janebová.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public