The seventh annual Week of Science and Technology, organized by the Academy of Sciences of the Czech Republic, took place in five cities - Brno, České Budějovice, Olomouc, Ostrava and Prague. The program included speeches by top professionals, presentations of significant experiments, workshops, non-traditional exhibitions, science cafés, and visits to laboratories and academic workplaces. The Week of Science and Technology also featured the European itinerant exhibition focusing on optics and optical technologies, titled The Fascination of Light. The exhibition took place November 1 to 8 in Veletržní palác. and Marina Hužvárová, Luděk Svoboda.
Euro-Biolmaging, an EU project, aims to create a pan-European infrastructure for biological and biomedical imaging. It will consist of closely interlinked leading European imaging facilities offering to European researchers an open access to a wide range of innovative imaging technologies. These technologies are used, for example, in researching new diagnostics and curing serious diseases. The Euro-Biolmaging published a first call for future Euro-Biolmaging nodes in January 2014. In total, 71 imaging facilities from 19 countries submitted their Expression of Interest to become a Euro-Biolmaging node. The Czech Republic submitted two applications. and Pavel Hozák.
Vědecký poradní výbor evropských akademií (European Academies Science Advisory Council - EASAC) sdružuje akademie věd členských zemí EU, Norska a Švýcarska. Záměrem EASAC je připravovat evropským politikům nezávislá vědecká stanoviska a doporučení - každoročně vydává několik souhrnných zpráv nejen pro politiky, ale i laickou veřejnost., Oceans and seas play a crucial role in regulating our climate, nurturing biodiversity, and providing income and food to people around the world. At COP21, governments across the globe agreed that a more aggressive limit for global warming should be set as an essential step toward a more stable relationship between the ocean and climate. In spite of this positive direction, however, marine sustainability faces many challenges, according to a new report issued by the European Academies of Science Advisory Council (EASAC) and the European Commission's Joint Research Centre., and Ondřej Prášil.
Ruminants are often fed a high-concentrate (HC) diet to meet lactating demands, yet long-term concentrate feeding induces subacute ruminal acidosis (SARA) and leads to a decrease in milk fat. Buffering agent could enhance the acid base buffer capacity and has been used to prevent ruminant rumen SARA and improve the content of milk fat. Therefore, we tested whether a buffering agent increases lipid anabolism in the livers of goats and influences of milk fat synthesis. Twelve Saanen-lactating goats were randomly assigned to two groups: one group received a HC diet (Concentrate: Forage=60:40, Control) and the other group received the same diet with a buffering agent added (10 g sodium butyrate, C4H7NaO2; 10 g sodium bicarbonate, NaHCO3; BG) over a 20-week experimental period. Overall, milk fat increase (4.25±0.08 vs. 3.24±0.10; P<0.05), and lipopolysaccharide levels in the jugular (1.82±0.14 vs. 3.76±0.33) and rumen fluid (23,340±134 vs. 42,550±136) decreased in the buffering agent group (P<0.05). Liver consumption and release of nonesterified fatty acid (NEFA) into the bloodstream increased (P<0.05). Phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) and ribosomal protein S6 kinase (p70S6K) up-regulated significantly in the livers of the buffering agent group (P<0.05). It also up-regulated expression of the transcription factor sterol regulatory element binding protein-1c (SREBP-1c) and its downstream targets involved in fatty acid synthetic, including fatty acid synthetase (FAS), stearoyl-CoA desaturase (SCD-1) and acetyl-CoA carboxylase 1 (ACC1) (P<0.05). The BG diet increased insulin levels in blood (19.43±0.18 vs. 13.81±0.10, P<0.05), and insulin receptor was likewise elevated in the liver (P<0.05). Cumulatively, the BG diet increased plasma concentrations of NEFA by INS-PI3K/AKTSREBP- 1c signaling pathway promoting their synthesis in the liver., L. Li, M. L. He, K. Wang, Y. S. Zhang., and Obsahuje bibliografii
Dairy goats are often fed a high-concentrate (HC) diet to meet their lactation demands; however, long-term concentrate feeding is unhealthy and leads to milk yield and lactose content decreases. Therefore, we tested whether a buffering agent is able to increase the output of glucose in the liver and influence lactose synthesis. Eight lactating goats were randomly assigned to two groups: one group received a HC diet (Concentrate : Forage = 6:4, HG) and the other group received the same diet with a buffering agent added (0.2 % NaHCO3, 0.1 % MgO, BG) over a 19-week experimental period. The total volatile fatty acids and lipopolysaccharide (LPS) declined in the rumen, which led the rumen pH to become stabile in the BG goats. The milk yield and lactose content increased. The alanine aminotransferase, aspartate transaminase, alkaline phosphatase, pro-inflammatory cytokines, LPS and lactate contents in the plasma significantly decreased, whereas the prolactin and growth hormone levels increased. The hepatic vein glucose content increased. In addition, pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6- phosphatase (G6PC) expression in the liver was significantly up-regulated. In the mammary glands, the levels of glucose transporter type 1, 8, 12 as well as of sodium-glucose cotransporter 1 increased. Cumulative buffering agent treatment increased the blood concentrations of glucose via gluconeogenesis and promoted its synthesis in the liver. This treatment may contribute to the increase of the milk yield and lactose synthesis of lactating goats., L. Li, M. L. He, Y. Liu, Y. S. Zhang., and Seznam literatury