Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk; the underlying mechanism remains unexplained. This study aimed to investigate the relationships between body composition and bone and glucose metabolism in postmenopausal women wit h T2DM. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) and body composition. A total of 68 postme nopausal women with T2DM and 71 controls were eligible for the study. In contrast to normal BMD in T2DM, a similar prevalence of low-trauma fractures was observed in both groups. T2DM women had significantly higher Trunk fat% and A/G ratio and significantly lower Legs LM% and Legs FM%. Legs LM% was significantly lower in fractured T2DM group and negatively correlated with glycaem ia and HbA1c (p<0.01). Serum osteocalcin was significantly lower in T2DM and inversely correlated with FM%, Trunk FM% and A/G ratio (p<0.01) and positively correlated with Legs FM% and total LM% (p<0.05). In conclusion, abdominal obesity and decrease in mu scle mass may contribute to low bone formation in T2DM women. Further research is needed to unravel underlying pathophysiological mechanisms and to determine whether maintenance of muscle mass, especially in the lower extremities and/or reduction of centra l fat mass can prevent fractures., I. Raška Jr., M. Rašková, V. Zikán, J. Škrha., and Obsahuje bibliografii
Variants within the FTO gene are important determinants of body mass index (BMI), but their role in determination of BMI changes after combined dietary/physical ac tivity intervention is unclear. We have analyzed 107 unrelated overweight non-diabetic Czech females (BMI over 27.5 kg/m2 , age 49.2±12.3 years). FTO variants rs17817449 (first intron) and rs17818902 (third intron) were genotyped. The life style mo dification program (10 weeks) consisted of an age- matched reduction of energy intake and exercise program (aerobic exercise 4 times a week, 60 min each). The mean BMI before intervention was 32.8±4.2 kg/m2 and the mean achieved weight loss was 4.8±3.5 kg (5.3±3.5 %, max. -15.5 kg, min. +2.0 kg, p<0. 01). No significant association between BMI decrease and FTO variants was found. Also waist-to-hip ratio, body composition (body fat, water, active tissue), lipid parameters (total, LDL and HDL cholesterol, triglycerides) glucose and hsCRP change s were independent on FTO variants. FTO variants rs17817449 and rs17818902 are not associated with BMI changes after combined short time dietary/physical activity intervention in overweight females., D. Dlouhá ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
In the present paper we describe changes of anatomical parameters in inbred Lewis strain rats, namely their body weight, body weight gain per week, absolute and relative heart, thyroid gland and skeletal muscle weights, that are assumed to reflect experimentally altered thyroid status. The hyperthyroid state was induced by DL-thyroxine or Na 3,3',5-triiodo-L-thyronine, while methimazole was employed for inducing hypothyroidism. We have found that when compared to euthyroid rats, hypothyroidism resulted in a significantly lower body weight gain, absolute and relative heart weight and, in contrast, in a significant increase of absolute and relative thyroid gland weight. On the other hand, hyperthyroidism led to a significant increase of absolute and relative heart weight and to a significant reduction of absolute and relative thyroid gland weight. However, the body mass was not significantly altered in hyperthyroidism as compared with euthyroid rats. We conclude that our protocol leads to chronic hyper- or hypothyroidism as demonstrated by body, heart and thyroid gland weight changes. These anatomical data can thus be utilized as supplemental criteria for the assessment of the thyroid state of experimental rats., T. Soukup, G. Zachařová, V. Smerdu, I. Jirmanová., and Obsahuje bibliografii
Studie otevírá téma fungování expertního prostředí psychodisciplín (psychiatrie, psychologie, psychoterapie apod.) v socialistickém Československu, a to nikoli ve smyslu jejich vnitrooborového vývoje, nýbrž proměny jejich společenské a kulturní funkce a vztahu k politické moci. Autorka sleduje oborové společenství psychoterapeutů od šedesátých let, jeho polooficiální institucionální a vzdělávací platformy, prosazování psychoterapie v systému socialistického zdravotnictví, její vztah k ostatním psychodisciplínám a komunikaci s odbornými trendy na Západě. V centru její pozornosti je zejména první vzdělávací psychoterapeutický systém v Československu označovaný jako SUR (jde o akronym utvořený z iniciál příjmení tří zakladatelů - Jaroslava Skály, Edmunda Urbana a Jaromíra Rubeše), který fungoval od roku 1967 a jímž do konce osmdesátých let prošlo na dva tisíce účastníků. Vyznačoval se především sebezkušenostním principem výcviku, kdy na sebe terapeuti aplikovali stejné metody a režim jako na pacienty. Po roce 1989 zažil obor obrovský rozkvět a psychoterapeutické přístupy k mezilidským vztahům i vlastnímu „já“ se staly nejen módní záležitostí a dobrým obchodním artiklem, ale též hlubší součástí každodenního života. Tuto proměnu autorka konfrontuje s literaturou věnovanou takzvané psychoterapeutizaci společnosti v západní Evropě. Uzavírá, že Michelem Foucaultem inspirované analýzy psychodisciplín jako opory expertního vládnutí (Nikolas Rose) jsou sice lákavé i pro výklad období neoliberální dominance v českých zemích, avšak pomíjejí specifický historický kontext subverzivnosti psychoterapie v pozdním socialismu, využívání zdrojů socialistického zdravotnictví i jejich výpadku po roce 1989., a1_The study opens the topic of the functioning of the expert environment of psychic disciplines (psychiatry, psychology, psychotherapy, etc.) in socialist Czechoslovakia; not in the sense of their intradisciplinary evolution, but rather with a view to transformations of their social and cultural function and relationship to political powers-that-be. The authoress monitors the professional community of psychotherapists since the 1960s, its semi-official institutional and educational platforms, promotion of psychotherapy in the socialist system of medical care, relation of psychotherapy to other psychic disciplines, and communication with professional trends in the West. She focuses maily on the first educational psycho- therapeutic system in Czechoslovakia known as SUR (it is an acronym consisting of the initials of its three founders - Jaroslav Skála, Edmund Urban and Jaromír Rubeš), which was in use since 1967 and which some 2,000 participants passed through by the end of the 1980s. It was characterized by a self-experience training principle, with therapists applying the same metods and regimes to themselves as to patients. Since 1989 the discipline has experienced a tremendous boom and psychotherapeutic approaches to interpersonal relations and to the "ego" have become not just an "in" thing and a good business, but also a deeper part of everyday life. The authoress confronts the transformation with literature dedicated to the so-called psychotherapization of society in Western Europe., a2_She concludes that analyses of psychic disciplines as tools of expert rule (Nikola Rose), which were inspired by Michel Foucault, while potentially tempting as an interpretation tool of the period of neo-liberal dominance in the Czech Lands, ignore the specific historical context of the subversive nature of psychotherapy during the period of late socialism, utilization of resources of the socialist medical care system, and their failure after 1989., Adéla Gjuričová., and Obsahuje bibliografii a bibliografické odkazy