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20742. Série komplikací po srdeční transplantaci – kazuistika

Creator:
Honěk, Tomáš, Krejčí, Jan, Němec, Petr, Adam, Zdeněk, Žampachová, Víta, Feitová, Věra, and Špinarová, Lenka
Format:
print, text, and regular print
Type:
model:article, article, Text, kazuistiky, práce podpořená grantem, and TEXT
Subject:
lidé, lidé středního věku, ženské pohlaví, srdeční selhání--etiologie--chirurgie, amyloidóza--diagnóza--komplikace, transplantace srdce, pooperační komplikace, invazivní plicní aspergilóza--diagnóza--farmakoterapie--patologie, biopsie, myokard--patologie, plíce--radiografie, tomografie rentgenová počítačová, vorikonazol--škodlivé účinky--terapeutické užití, antifungální látky--škodlivé účinky--terapeutické užití, amfotericin B--terapeutické užití, spontánní regrese nádoru, imunosuprese--škodlivé účinky, primární amyloidóza, and endomyokardiální biopsie
Language:
Czech and English
Description:
Ortotopická transplantace srdce je zavedenou metodou léčby pacientů v terminálním stadiu srdečního selhání, která zlepšuje přežívání těchto pacientů. Cenou za podávání imunosupresivní léčby je řada potenciálních rizik, jedněmi z nejzávažnějších jsou infekční komplikace. Kazuistika popisuje případ pacientky se srdečním selháním na podkladě primární amyloidózy, která podstoupila srdeční transplantaci. Po transplantaci byla v plánu kurativní hematoonkologická léčba, která však vzhledem ke kompletní remisi základního onemocnění nebyla uskutečněna. V časném potransplantačním období pacientka prodělala řadu komplikací, z nichž nejzávažnější byla invazivní plicní aspergilóza. Tato infekce byla úspěšně zaléčena vorikonazolem a pacientka je nyní 28 měsíců po srdeční transplantaci ve velmi dobrém klinickém stavu bez známek aktivní infekce., Orthotopic heart transplantation is an established method of treatment for patients with end‑stage heart failure, which improves the survival of these patients. The use of immunosuppressive therapy comes at the price of a number of potential risks, the most serious being infectious complications. Our case report describes a patient with heart failure on the basis of primary amyloidosis who underwent cardiac transplantation. Hemato‑oncological curative treatment was planned after transplantation, but has not been applied due to the complete remission of the primary disease. In the early post‑transplant period, the patient experienced a number of complications, the most serious being invasive pulmonary aspergillosis. This infection was successfully controlled using voriconazole, and 28 months after heart transplantation the patient is now in good clinical condition with no signs of active infection., and Honěk T., Krejčí J., Němec P., Adam Z., Žampachová V., Feitová V., Špinarová L.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

20743. Series praepositorum, decanorum, archidiaconorum, aliorumque praelatorum et canonicorum S. Metropolitanae Ecclesiae Pragensis a primordiis usque ad praesentia tempora

Creator:
Antonín Podlaha
Publisher:
Metropolitní kapitula u sv. Víta
Format:
print and 441 s., 24 fot. : fot
Type:
model:monograph and TEXT
Subject:
Arcibiskupství pražské, Metropolitní kapitula u sv. Víta, and Pražský hrad (území)
Language:
Latin and Undetermined
Description:
Chronologicky řazené latinské životopisy členů pražské metropolitní kapituly u sv. Víta, tj. kanovníků, děkanů, proboštů, prelátů a kleriků v letech 989-1911 s citacemi archivních pramenů o nich pojednávajících., Pražská Svatovítská kapitula byla (a dosud je) sbor kněží pomáhajících pražskému biskupovi (po r. 1344 arcibiskupovi) při správě diecéze i při náboženských úkonech. Kniha českého historika a kunsthistorika, světícího biskupa Podlahy přetiskuje všechny zachované prameny o životě 918 členů Svatovítské kapituly od první písemné zmínky o proboštu Wilicovi z r. 989 po dobu vydání knihy (1912). Kniha je provázena reprodukcemi dobových rytin a fotografií některých členů kapituly a doplněna souhrnným rejstříkem a fotografiemi pečetí kanovníků v příloze., Concinnavit Antonius Podlaha Antonín Podlaha, Církve a náboženství v Praze., Pražské biskupství a arcibiskupství., Církevní řády a sbory působící v Praze., Církevní majetek v Praze., and Poděkování panu Michalovi Faustovi za podnět k digitalizaci této knihy.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

20744. SERMO M. NICOLAI TROILI HAGIOCHORANI pro tempore FACULTATIS PHILOSOPHICAE IN ACADEMIA PRAGENSI DECANI DE BOIEMIA PIA CONTRA ROXOLANOS IN SOLENNI PROMOTIONE MAGISTRORVM ET BACCALAUREORUM ... invitatos ...

Creator:
Troilus, Mikuláš and Sessius, Pavel
Publisher:
Sessius, Pavel
Format:
print and [20] ff ; 4°
Type:
model:monograph and TEXT
Subject:
století 17., historiografie, and 094
Language:
Latin
Description:
BCBT41946
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

20746. Serological diagnosis of cystic echinococcosis in cattle

Creator:
Bulashev, Aitbay K, Suranshiev, Zhanbolat A, Akibekov, Orken S, Akanova, Zhanara Zh, and Abulgazimova, Gulmira A
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
měchožil zhoubný, Echinococcus granulosus, protoscoleces, excretory-secretory antigen, monoclonal antibody, ELISA, 2, and 59
Language:
English
Description:
An IgM murine monoclonal antibody (MAb) was obtained against the excretory-secretory antigen (ES-Ag) of in vitro reared protoscoleces of Echinococcus granulosus (Batsch, 1786). Western blotting revealed that the MAb recognised a 20.6 kDa protein of this ES-Ag. The MAb was used in sandwich enzyme-linked immunosorbent assay (s-ELISA) for selective sensitisation of the solid phase with the protoscolex-specific protein from its ES-Ag and somatic antigen (S-Ag) to examine serum samples of 108 cows from a cystic echinococcosis (CE) endemic area for specific antibodies and to compare the results with those from necropsies and an indirect ELISA (i-ELISA). The sensitivity of s-ELISA/ES-Ag, s-ELISA/S-Ag and i-ELISA/S-Ag was 48%, 52% and 62%, respectively. The low sensitivity of the ELISA was probably caused by the fact that 13 cows (62%) were infected with sterile cysts (acephalocysts and/or calcified foci) only. A relatively high specificity (80%) of s-ELISA/ES-Ag was observed in cows with fertile cysts. It also detected antibodies in the serum of two cows that had recovered from the disease according to the necropsy. The i-ELISA/S-Ag gave false results in testing sera from a healthy animal and from a cow with tubercular foci. Further analysis will be necessary to define more precisely the value of this study, because the duration of antibody elimination from the bloodstream of recovered cattle remains unknown. The solution of this problem will increase the specificity of the proposed test in monitoring herbivorous animals for CE., Aitbay K. Bulashev, Zhanbolat A. Suranshiev, Orken S. Akibekov, Zhanara Zh. Akanova, Gulmira A. Abulgazimova., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

20747. Serological markers of enterocyte damage and apoptosis in patients with celiac disease, autoimmune diabetes mellitus and diabetes mellitus type 2

Creator:
Iva Hoffmanová, Daniel Sánchez, Věra Hábová, Michal Anděl, Ludmila Tučková, and Helena Tlaskalová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, autoimunita, diabetes mellitus, autoimmunity, cytokeratin 18 caspase-cleaved fragment, intestinal fatty acid-binding protein, soluble CD14, intestinal barrier, 14, and 612
Language:
English
Description:
Impairment of mucosal barrier integrity of small intestine might be causative in immune-mediated gastrointestinal diseases. We tested the markers of epithelial apoptosis – cytokeratin 18 caspase-cleaved fragment (cCK-18), and enterocyte damage – intestinal fatty acid-binding protein (I-FABP) and soluble CD14 (sCD14) in sera of patients with untreated celiac disease (CLD), those on gluten-free diet (CLD-GFD), patients with autoimmune diabetes mellitus (T1D), T1D with insulitis (T1D/INS), and diabetes mellitus type 2 (T2D). We found elevated levels of cCK-18 (P<0.001), I-FABP (P<0.01) and sCD14 (P<0.05) in CLD when compared to healthy controls. However, the levels of cCK-18 (P<0.01) and I-FABP (P<0.01) in CLD-GFD were higher when compared with controls. Interestingly, elevated levels of cCK-18 and I-FABP were found in T2D and T1D (P<0.001), and T1D/INS (P<0.01, P<0.001). Twenty-two out of 43 CLD patients were seropositive for cCK-18, 19/43 for I-FABP and 11/43 for sCD14; 9/30 of T2D patients were positive for cCK-18 and 5/20 of T1D/INS for sCD14, while in controls only 3/41 were positive for cCK-18, 3/41 for I-FABP and 1/41 for sCD14. We documented for the first time seropositivity for sCD14 in CLD and potential usefulness of serum cCK-18 and I-FABP as markers of gut damage in CLD, CLD-GFD, and diabetes., I. Hoffmanová, D. Sánchez, V. Hábová, M. Anděl, L. Tučková, H. Tlaskalová-Hogenová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

20748. Seroprevalence and risk factors of infections with Neospora caninum and Toxoplasma gondii in hunting dogs from Campania region, southern Italy

Creator:
Machačová, Tereza, Eva Bártová, Kamil Sedlák, Slezáková, Radka, Marie Budíková, Piantedosi, Diego, and Veneziano, Vincenzo
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
toxoplazmóza, vlci, toxoplasmosis, wolves, Itálie jižní, Italy, Southern, neosporosis, IFAT, antibody titres, Canis lupus, 2, and 59
Language:
English
Description:
Hunting dogs have probably a higher level of exposure to Neospora caninum Dubey, Carpenter, Speer, Topper et Uggla, 1988 and Toxoplasma gondii Nicolle et Manceaux, 1908 than other canine populations for their different lifestyle. The aim of our survey was to determine the seroprevalence of N. caninum and T. gondii in hunting dogs from southern Italy and assess risk factors related to these protozoan infections. Blood samples were collected from 398 hunting dogs (19 different breeds, aged from 5 month to 14 years). The sera were screened by indirect fluorescence antibody test; a titre ≥ 50 was considered positive. Antibodies to N. caninum and T. gondii were detected in 59 (15%) dogs with titres from 50 to 3 200 and in 94 (24%) dogs with titres from 50 to 1 600, respectively, with co-infection in 25 (6%) dogs. Statistical difference (p ≤ 0.05) was found only for infection with T. gondii between two age groups: ≥ 2-4 years (16%) and ≥ 4-7 years (33%); other observed characteristics were without statistical significance. Our results suggest that the hunting dogs could play an important role in the transmission cycle of N. caninum between wild animals and livestock. This is the first detection of antibodies to T. gondii in hunting dogs in Italy., Tereza Machačová, Eva Bártová, Kamil Sedlák, Radka Slezáková, Marie Budíková, Diego Piantedosi, Vincenzo Veneziano., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

20749. Seroprevalence of Toxoplasma gondii in hunted wild boars (Sus scrofa) from southeastern France

Creator:
Roqueplo, Cédric, Blaga, Radu, Marié, Jean-Lou, Vallée, Isabelle, and Davoust, Bernard
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
toxoplazmóza, epidemiologie, prase divoké, toxoplasmosis, epidemiology, wild boar, Francie, France, agglutination test, wildlife, seroprevalence, 2, and 59
Language:
English
Description:
Toxoplasma gondii (Nicolle et Manceaux, 1908) is an obligate intracellular, parasitic protozoan within the phylum Apicomplexa that causes toxoplasmosis in mammalian hosts (including humans) and birds. Since meat of wild boar, Sus scrofa (Linnaeus), has been demonstrated to be a potential source of human infection, a careful evaluation of the prevalence of infection with T. gondii in hunted animals is needed to protect public health. In the Var area in southeastern France, we performed a spatio-temporal survey in order to investigate the prevalence of IgG antibodies in wild boars shot by hunters in the Canjuers military camp during two subsequent hunting seasons. Of 841 wild boars screened, antibodies (IgG) to T. gondii (modified agglutination test, cut-off 1 : 6) were found in 141 (16.8%) muscle extract samples. A significant association (p < 0.001) was found between positivity and age, but not gender, and hunting districts. The results obtained indicate that consumption of raw or undercooked meat from wild boars carries an important risk of infection with T. gondii. Wild boars may be considered as a bioindicator of parasite circulation in this ecosystem., Cédric Roqueplo, Radu Blaga, Jean-Lou Marié, Isabelle Vallée, Bernard Davoust., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

20750. Seroprevalence of Toxoplasma gondii infection in goats from the south-west region of Poland and the detection of T. gondii DNA in goat milk

Creator:
Sroka, Jacek, Kusyk, Paweł, Bilska-Zając, Ewa, Karamon, Jacek, Dutkiewicz, Jacek, Wójcik-Fatla, Angelina, Zając, Violetta, Stojecki, Krzysztof, Różycki, Mirosław, and Cencek, Tomasz
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
toxoplazmóza, genotyp, sérologie, toxoplasmosis, genotype, serology, DAT, PCR, 2, and 59
Language:
English
Description:
Toxoplasma gondii (Nicolle et Manceaux, 1908) is an obligatory intracellular protozoan parasite prevalent in animals and humans worldwide having medical and veterinary importance on account of causing abortion or congenital disease in intermediate hosts, including man. Since T. gondii has already been identified in the milk of goats, Capra aegagrus hircus (Linnaeus), the possibility of acquiring infection by ingesting unpasteurised goat milk should be taken into consideration. Thus, the aim of the present study was to determine the presence of T. gondii DNA in goat milk. First, 73 goats (females) from 36 farms located in Poland were examined serologically by direct agglutination test (DAT) to estimate the T. gondii serological status. Milk samples from 60 selected lactating females were examined for the presence of T. gondii DNA by Real time PCR and nested PCR (B1 gene). To estimate the clonal type of detected T. gondii, multiplex PCR was performed using 6 markers. In DAT, positive results were found in 70% of 73 goats. Among examined 60 milk samples, 65% were positive in Real time PCR and 43% in nested PCR. It is noteworthy that 11 samples positive in PCR were collected from seronegative goats. The multilocus PCR analysis mostly revealed the occurrence of genotype III, which is relatively rare in Europe. The recorded high prevalence of anti-Toxoplasma antibodies in tested goats (70%), associated with a high prevalence of T. gondii DNA in goat milk samples (65%), indicates a potential risk of the parasite transmission through goat milk ingestion., Jacek Sroka, Paweł Kusyk, Ewa Bilska-Zając, Jacek Karamon, Jacek Dutkiewicz, Angelina Wójcik-Fatla, Violetta Zając, Krzysztof Stojecki, Mirosław Różycki, Tomasz Cencek., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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