Direct cell-to-cell communication in the heart is maintained via gap junction channels composed of proteins termed connexins. Connexin channels ensure molecular and electrical signals propagation and hence are crucial in myocardial synchronization and heart function. Disease-induced gap junctions remodeling and/or an impairment or even block of intercellular communication due to acute pathological conditions results in derangements of myocardial conduction and synchronization. This is critical in the development of both ventricular fibrillation, which is a major cause of sudden cardiac death and persistent atrial fibrillation, most common arrhythmia in clinical practice often resulting in stroke. Many studies suggest that alterations in topology (remodeling), expression, phosphorylation and particularly function of connexin channels due to age or disease are implicated in the development of these life-threatening arrhythmias. It seems therefore challenging to examine whether compounds that could prevent or attenuate gap junctions remodeling and connex in channels dysfunction can protect the heart against arrhythmias that cause sudden death in humans. This assumption is supported by very recent findings showing that an increase of gap junctional conductance by specific peptides can prevents atrial conduction slowing or re-entrant ventricular tachycardia in ischemic heart. Suppression of ischemia-induced dephosphorylation of connexin seems to be one of the mechanisms involved. Another approach for identifying novel treatments is based on the hypothesis that even non-antiarrhythmic drugs with antiarrhythmic ability can modulate gap junctional communication and hence attenuate arrhythmogenic substrates., N. Tribulová, V. Knezl, Ľ. Okruhlicová, J. Slezák., and Obsahuje bibliografii a bibliografické odkazy
Myocardial Infarction (MI) also known as heart attack is one of the most dangerous cardiovascular diseases. Accurate early prediction can effectively reduce the mortality rate caused by MI. The early stages of MI may only have subtle indications which can be varied in variable risk factors and making diagnosis difficult even for experienced cardiologists. In this paper the computer aided detection system is proposed to find the risk level of MI using the supervised classifier. The MI prediction system is developed using Feed Forward Neural Network (FFNN), Cascade Correlation Neural Network (CNN), and Support Vector Machine (SVM). Genetic Optimized Neural Network (GAANN), Particle Swarm Optimized Neural Network (PSONN) and also the performance of the Computer Aided Detection system is analyzed using various performance metrics.
Myofibrillar creatine kinase (CK) that buffers ATP during fluctuating muscle energy metabolism has been selected for studies of conformational changes underlying the cellular control of enzyme activity. The force field was computed for three energetic states, namely for the substrate-free CK molecule, for the molecule conjugated with the MgATP complex, and for the molecule conjugated with the pair of reactants MgATP-creatine. Without its substrates, the enzyme molecule assumes an inactive "open" form. Upon binding of the MgATP complex, the CK molecule takes up a reactive "closed" conformation. Subsequent binding of creatine yields a nonreactive "intermediary" conformation. Acid-base catalysis is considered to be the basic principle for the reversible transfer of the phosphoryl group between the substrates. The results indicate that the substrate-induced energy minimizing conformational changes do not represent a sufficient condition for CK activity and that some other essential component of physiological control at the cellular level is involved in the transition from the intermediary to the closed structure of the molecule., J. A. Mejsnar, B. Sopko, M. Gergor., and Obsahuje bibliografii
The article deals with the theoretical discussions of the second half of the 19th century and the early 20th century taking place within the Czech society and among its political leaders on introuduction of the universal suffrage and on the appropriate level of its equality and Článek zahrnuje poznámkový aparát pod čarou
In the presented three newspaper articles from 1920s, Soviet writer Andrei Platonov criticizes the exploitation of the earth and human alienation from nature in the context of the Russian famine of 1921–1922, pointing to solar energy as the basis for socialist development. Introduced by Monika Woźniak and translated by Alena Machoninová.
This paper takes into consideration the role of myth and religion in Kr̥ṣṇā Sobtī’s novel Zindagīnāmā [A book of life, 1979]. The introduction highlights the composition of Śāhjī’s household, where people of different faiths live, and explores the fellowship among Muslims, Hindus and Sikhs, which was a distinguishing feature of Sufism in pre-partition Panjab. The introduction is followed by a section which deals with the core theme of myth and religion. Three main myths are dealt with in the narrative: the Islamic myth of Khvājā Khizr; a Hindu myth based on the concept of avtār; and the Hindu myth of the sun and the moon. When compared with the myth, however, it is religion which plays a more important role in the novel. The paper analyzes the subject of religion through three main characters: spirituality, through Śāhjī’s younger brother, Kāśī Śāh; religion in everyday life, through Śāhjī’s wife, Śāhnī; and human love and divine love, through the young Muslim girl, Rābyā̃, with whom Śāhjī falls in love. Her name recalls the greatest woman Sufi mystic poet, Rābi‘a of Basra (c. 717-801), who introduced the concept of Divine Love. As the theme of divine love is closely linked to Sufism, it is the love-romances of the Panjabi Sufi poets, in particular, that are incorporated into the story.
Zpráva o 49. ročníku muzikologického kolokvia, iuskutečněného na půdě Ústavu hudební vědy Filozofické fakulty Masarykovy university v Brně ve dnech 24. - 26. listopadu 2014., Jarmila Procházková., Rubrika: Konference, and Cizojazyčné resumé není.