Meconium aspiration syndrome (MAS) is meconium-induced respiratory failure of newborns associated with activation of inflammatory and oxidative pathways. For severe MAS, exogenous surfactant treatment is used which improves respiratory functions but does not treat the inflammation. Oxidative process can lead to later surfactant inactivation; hence, surfactant combination with antioxidative agent may enhance the therapeutic effect. Young New Zealand rabbits were instilled by meconium suspension and treated by surfactant alone, Nacetylcysteine (NAC) alone or by their combination and oxygenventilated for 5 h. Blood samples were taken before and 30 min after meconium application and 30 min, 1, 3 and 5 h after the treatment for evaluating of oxidative damage, total leukocyte count, leukocyte differential count and respiratory parameters. Leukocyte differential was assessed also in bronchoalveolar lavage fluid. NAC alone had only mild therapeutic effect on MAS. However, the combination of NAC and surfactant facilitated rapid onset of therapeutic effect in respiratory parameters (oxygenation index, PaO2/FiO2) compared to surfactant alone and was the only treatment which prevented neutrophil migration into the lungs, oxidative damage and lung edema. Moreover, NAC suppressed IL-8 and IL-β formation and thus seems to be favorable agent for improving surfactant therapy in MAS., J. Kopincová, D. Mokrá, P. Mikolka, M. Kolomazník, A. Čalkovská., and Obsahuje bibliografii
Geiss, Keller and Oppermann (2013) introduced the notion of n-angulated category, which is a “higher dimensional” analogue of triangulated category, and showed that certain (n-2)-cluster tilting subcategories of triangulated categories give rise to n-angulated categories. We define mutation pairs in n-angulated categories and prove that given such a mutation pair, the corresponding quotient category carries a natural n-angulated structure. This result generalizes a theorem of Iyama-Yoshino (2008) for triangulated categories., Zengqiang Lin., and Obsahuje seznam literatury
This paper is a continuation of investigations of n-irmer product spaces given in [5, 6, 7] and an extension of results given in [3] to arbitrary natural n. It concerns families of projections of a given linear space L onto its n-dimensional subspaces and shows that between these families and n-inner products there exist interesting close relations.
An interaction between N-methyl-D-aspartate (NMDA) and MK-801 was examined in mice using a modified elevated plus-maze paradigm that allows assessment of the adaptive form of spatial memory. NMDA administered (s.c.) immediately after the acquisition session protected the animals against the amnesia induced by MK-801 given shortly before the retention session. Behavioral performance, expressed as the transfer latency, and therefore spatial memory potency of NMDA plus MK-801 treated animals was comparable with that of both NMDA-treated animals and the controls., Z. Hliňák, I. Krejčí., and Obsahuje bibliografii
Kolmogorov N-widths are an approximation theory concept that, for a given problem, yields information about the optimal rate of convergence attainable by any numerical method applied to that problem. We survey sharp bounds recently obtained for the N-widths of certain singularly perturbed convection-diffusion and reaction-diffusion boundary value problems.