Hypertrophied hearts are known for increased risk of arrhythmias and are linked with reduced ischemic tolerance. However, still little is known about state characterized only by increased left ventricle (LV) mass fraction. Seventeen isolated rabbit hearts with various LV mass were divided into two groups according to LV weight/heart weight ratio (LVW/HW ratio), namely group H and L (with higher and lower LVW/HW ratio, respectively) and underwent three short cycles of global ischemia and reperfusion. The differences in electrogram (heart rate, QRSmax, mean number, onset and dominant form of ventricular premature beats) and in biochemical markers of myocardial injury (creatine kinase, lactate dehydrogenase - LDH) and lipid peroxidation (4-hydroxy-2-nonenal - 4-HNE) were studied. As compared to group L, hearts in group H exhibited lower tolerance to ischemia expressed as higher incidence and severity of arrhythmias in the first ischemic period as well as increase of LDH and 4-HNE after the first reperfusion. In the third cycle of ischemia-reperfusion, the preconditioning effect was observed in both electrophysiological parameters and LDH release in group H. Our results showed consistent trends when comparing changes in electrograms and biochemical markers. Moreover, 4-HNE seems to be good potential parameter of moderate membrane alteration following ischemia-reperfusion injury., M. Hlaváčová, V. Olejníčková, M. Ronzhina, T. Stračina, O. Janoušek, M. Nováková, P. Babula, J. Kolářová, I. Provazník, H. Paulová., and Obsahuje bibliografii
Mikrosvět elementárních částic, atomů a procesů odehrávajících se mezi nimi je plný podivností. Částice může projít naráz dvěma různými štěrbinami, fotony mohou být navzájem provázané na obrovské vzdálenosti, kočka (alespoň ona pověstná Schrödingerova) může být zároveň živá i mrtvá... Může pozoruhodný kvantový svqt dovolit i stav, kdy by nějaká látka bya sočasně pevná a supratekutá? A mohou kvantové supratekuté systémy pomoci osvětlit jeden z posledních nevyřešených problémů klasické fyziky - turoblenci? Vědci, včetně českých, intenzivné hledají odpovědi. and Jana Olivová.
The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain condition s, depending on dosage (serum concentration), duration of treatment and interactions among individual elements. We review the beneficial and toxic effects of key elements on bone homeostasis., I. Zofkova, M. Davis, J. Blahos., and Obsahuje bibliografii
Cardiovascular diseases are the most common cause of mortality and morbidity in most populations. As the traditional modifiable risk factors (smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS). The Czech part of the study included data from 999 males, and compared them with the post-MONICA study (1,259 males, representing general population). The Lithuanian study included 479 male patients and 456 age-matched controls. The Kazakhstan part included 232 patients and 413 controls. In two countries, the most robust ACS risk factor was smoking (OR 3.85 in the Czech study and 5.76 in the Lithuanian study), followed by diabetes (OR 2.26 and 2.07) and hypertension (moderate risk elevation with OR 1.43 and 1.49). These factors did not influence the ACS risk in Kazakhstan. BMI had no significant effect on ACS and plasma cholesterol was surprisingly significantly lower (P<0.001) in patients than in controls in all countries (4.80 ±1.11 vs. 5.76 ±1.06 mmol /l in Czechs; 5.32 ±1.32 vs. 5.71 ±1.08 mmol /l in Lithuanians; 4.88 ±1.05 vs. 5.38±1.13 mmol /l in Kazakhs/Russians). Results from our study indicate substantial heterogeneity regarding major CVD risk factors in different populations with the exception of plasma total cholesterol which was inversely associated with ACS risk in all involved groups. These data reflect ethnical and geographical differences as well as changing pattern of cardiovascular risk profiles., J. A. Hubacek, V. Stanek, M. Gebauerova, V. Adamkova, V. Lesauskaite, D. Zaliaduonyte-Peksiene, A. Tamosiunas, A. Supiyev, A. Kossumov, A. Zhumadilova, J. Pitha., and Obsahuje bibliografii
Motto Strategie AV21 „Špičkový výzkum ve veřejném zájmu“ mj. předesílá podporu mezioborové a meziinstitucionální synergie více než 50 pracovišť Akademie věd. Právě proto, aby výzkum opravdu sloužil společnosti, otevřela Akademie věd nové Centrum transferu technologií, jehož prostory se hostům slavnostně představily 16. května 2016. and Marina Hužvárová.
Stať se zabývá trávením volného času. Nejprve uvádíme význam trávení volného času a odpovídající sociologickými koncepty. V empirické části analyzujeme data z mezinárodního výzkumu ISSP 2007 – Volný čas a sport. Popisujeme frekvenci 13 volnočasových aktivit a spolu s vnímanými funkce volného času je srovnáváme s 18 evropskými zeměmi. V následující části nejprve pomocí klastrové analýzy rozkrýváme strukturu volnočasových aktivit v České republice, identifikovány byly tři hlavní životní styly: (1) kulturní a sportovní aktivity mimo domov typické pro mladou generaci, (2) nakupování, navštěvování příbuzných, sledování TV a čtení příznačnou pro ženy a (3) domácí práce/kutilství charakteristické pro muže. Na závěr pomocí multinominální logistické regrese identifikujeme nositele těchto životních stylů z hlediska sociodemografických charakteristik., The article focuses on leisure activities in the Czech Republic. After the introductory part defining leisure and its functions, data from the international research ISSP 2007 Leisure and Sport are analyzed. Frequencies of 13 leisure acti - vities and perceived functions of leisure are described and the Czech results are briefly compared with the average of 18 European countries. Then attention is paid to the structure of leisure activities in the Czech society. Three main leisure clus - ters, i.e. types of lifestyle, were identified: (1) cultural and sporting activities outside home, (2) “female” culture (shopping, watching TV, reading books and visiting relatives), (3) “home-loving” style of life (doing handicrafts and do-it-yourself). The main sociodemographic characteristics of their followers are delineated using multinominal logistic regression., and Jiří Šafr, Věra Patočková.
Od počátku 90. let 20. století dochází k poměrně velkým změnám v reprodukčním chování obyvatel České republiky, mimo jiné výrazně narůstá podíl dětí narozených mimo manželství. Článek podrobně popisuje vývoj intenzity plodnosti nevdaných žen ve srovnání s ženami vdanými v letech 1989-2014 na základě dat běžné evidence. Pozornost je věnována třem hlavním vlivům působícím na podíl dětí narozených mimo manželství, nejvíce pochopitelně intenzitě mimomanželské a manželské plodnosti (podle věku a pořadí narozených dětí). Analýza ukazuje, že přestože dochází od počátku 21. století ke sbližování intenzity plodnosti vdaných a nevdaných žen, prokreační chování těchto žen se stále výrazně odlišuje (průměrný věk matky při narození (prvního) dítěte, struktura narozených dětí podle pořadí narození)., Since the beginning of the 1990´s there have been relatively large changes in the reproductive behaviour of the population of the Czech Republic, including a significant increase in the proportion of children born out of wedlock. The paper describes the development of fertility rates among unmarried and married women in the years 1989-2014 in detail. Attention is paid to three main influences which are responsible for the proportion of children born out of wedlock, and obviously above all to the rates of nonmarital and marital fertility (by age and by birth order). The analysis shows that although there has been a convergence of the rates of fertility of married and unmarried women since the beginning of the 21st century, the reproductive behaviour of these women is still significantly different (average age of mother at birth of (first) child, distribution of birth order)., Barbora Kuprová., and Obsahuje bibliografii
Cílem tohoto textu je zjistit, jestli se v čase mění podíl matek, které rodí děti mimo partnerský vztah, a jestli se mění také asociace tohoto rodinného uspořádání se sociodemografickými charakteristikami matek. Rodinná uspořádání, do kterých se rodí děti, se v posledních více než dvou dekádách značně proměnila, a proto lze očekávat, že se změnil i podíl a/ nebo charakteristiky žen, které své děti rodí mimo partnerství. Jedním z důvodů, proč toho o porodech mimo partnerství víme tak málo, jsou omezené datové zdroje, ze kterých můžeme informace čerpat. Proto je cílem tohoto textu také zmapovat možnosti měření rodinného uspořádání rodiček a porovnat výsledky, která nám k tématu poskytují., Single motherhood is known to have negative consequences on the wellbeing and life chances of mothers and their children. It appears as a consequence of parental dissolution or birth to an unpartnered woman. There are studies of divorce and union separation in the Czech Republic but less is known about women who bear their children outside unions. The goal of the paper is to determine if the proportion of mothers who bear children without having a partner changes in time and if there is a change in the socio-demographic characteristics of mothers. As the data on unpartnered childbearing are limited, the paper also aims to map the available data sources and their possibilities and limitations. Two data sources are used to measure births to unpartnered mothers, the birth register (BR) and the Labour Force Survey (LFS). BR data include mothers of liveborn infants in 2007-2014 (n is 886,467) but do not contain a direct measure of family arrangement. Single mothers are defined as those who did not provide information about newborn´s father. The LFS data set is limited to households with a member under one year of age interviewed in 1993-2010 (n is 8,172). Single motherhood is defined as an absence of mother´s partner in the household. Results about single motherhood are reported for all house holds and for those headed by one of the infant´s parents. The main independent variable is time period. Three maternal characteristics are controlled for, namely education, age, and parity. The proportion of children with unidentified fathers declined slightly from about 10% in 2007 to 8% in 2014. Both measures of unpartnered childbearing based on household composition suggest a growing trend in the 1993-2007 period and then stabilisation. The proportion of mothers without partners among all households with an infant rose from 7% (1993-1995) to 12-13% (2005-2010). As for households headed by child’s single parent, the number of single mothers is underestimated because a substantial proportion of tem live in households headed by other persons. There is a growing trend from 3% to 8%. These figures also indicate that the proportion of single mothers who live in their own households increased from 37% (1993-1995) to 60% (2008-2010). Logistic regression was used to test if the trends apply to mothers in all socio-demographic groups. The results suggest that each of the measures of unpartnered motherhood is strongly associated with low (i.e. primary) education, first parity, and low or high age of mothers (up to 25 or above 35 y.o.). Interaction between time period and maternal characteristics shows that the decline in the non-identification of fathers occured in all groups of mothers except those with low (i.e. primary or vocational) education and those of third or higher parity. These groups show a growing tendency not to acknowledge fathers. The absence of fathers in households with infants exhibited a similar trend in all groups of mothers. In sum, different definitions result in different estimates of unpartnered motherhood. Depending on the measure, the ratio of births outside unions was estimated between 8% and 12% at the end of the 2000s (i.e. the time period of 2008-2010 when all of the time series overlap). Measurement based on the absence of father in any type of household provides the highest estimate of the proportion of unpartnered childbearing, while the other two measures lead to lower estimates. The results regarding temporal trends in unpartnered childbearing also depend on measurement. This suggests that the absence of coresident partner and denial of information about child´s father are different events and they are likely to further differentiate in the future., Martina Štípková., and Obsahuje bibliografii
Tuková tkáň je endokrinní orgán produkující početné cytokiny. Změna v jejich regulacích může být příčinou patologických pochodů u obézních jedinců. Význam tukové tkáně ve vztahu k diabetu a ateroskleróze je intenzivně studován., Adipose tissue is an endocrine organ that produces numerous cytokines. Their dysregulations cause morbidity in obese individuals. The importance of this tissue in relation to diabetes and atherosclerosis is the subject of intense research., and Ilja Trebichavský, Petr Šíma.
The article deals with the typology of Baroque frontispieces in printed books published in Bohemian and Moravian printing houses in 1618-1765, which is viewed in terms of the function of the frontispieces in printing. The paper contains a detailed analysis of the main thematic variants of frontispieces. The thematic variants are analysed with respect to the content and genre of the work concerned with the aim to determine the main marketing strategies of Bohemian and Moravian printers, publishers or booksellers in the visual promotion of their products., Hana Beránková., Obsahuje anglický abstrakt a shrnutí., and Obsahuje bibliografii