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2. Emil Starkenstein in memoriam
- Creator:
- Michal Šimůnek and Antonín Kostlán
- Format:
- print, bez média, and svazek
- Type:
- article, medailony, model:article, and TEXT
- Subject:
- Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Starkenstein, Emil, 1884-1942, farmaceuti, farmakologie, oběti nacismu, pharmacists, pharmacology, victims of Nazism, 12, and 00
- Language:
- Czech
- Description:
- Michal V. Šimůnek, Antonín Kostlán.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3. Glucose release as a response to glucagon in rat hepatocyte culture: involvement of NO signaling
- Creator:
- Hassan Farghali, Hodis, J., Nikolína Kutinová-Canová, Petr Potměšil, Eva Kmoníčková, and Zdeněk Zídek
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, farmakologie, oxid dusnatý, glukagon, jaterní buňky, pharmacology, nitric oxide, glucagon, liver cells, glycogenolysis, 14, and 612
- Language:
- English
- Description:
- Glucagon and α-adrenergic-induced glycog enolysis is realized via the agonist/adenylyl cyclase/cAMP/protein kinase signaling pathway or via the activation of phosphorylase kinase by the mobilized calcium that supports the inhibition of glycogen synthase, respectively. The role of nitric oxide (NO) in this process has not been extensively studied. The present work was directed to the question whether NO is produced during glucagon-induced glycogenolysis in rat hepatocyte in a similar way like α-adrenoceptor stimulation. Glycogen-rich hepatocyte cultures were used. NO production (NO2-) was assessed under the influence of glucagon, dibutyryl cyclic AMP (db-cAMP), forskolin, the nitric oxide synthase (NOS) inhibitors Nω-nitro-L-arginine methyl ester (L-NAME) and aminoguanidine, and the NO donor S-nitroso-N-acetyl penicillamine (SNAP). Inducible NOS (iNOS) mRNA was examined by reverse transcription-polymerase chain reaction. Glycogenolysis was followed up by estimation of medium glucose levels. The amount of glucose and NO2- released by glycogen-rich hepatocytes was increased as a result of glucagon, db-cAMP, forskolin and SNAP treatments. iNOS gene expression was upregulated by glucagon. Glycogenolysis that occurs through glucagon receptor stimulation involves NO production downstream of transduction pathways through an isoform of NO synthase. The present and previous studies document possible involvement of NO signaling in glycogenolytic response to glucagon and adrenergic agonists in hepatocytes., H. Farghali, J. Hodis, N. Kutinová-Canová, P. Potměšil, E. Kmoníčková, Z. Zídek., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4. Hermanni Boerhaave De cognoscendis et curandis morbis aphorismi una cum ejusdem de materia medica et remediorum formulis libello ad singulos aphorismos digesto, ad fidem optimarum editionum recensiti et editi
- Creator:
- Boerhaave, Herman
- Publisher:
- Typis Jo. Thomae nob. de Trattnern, sac. caes. reg. aulae typographi et bibliop.
- Format:
- 1-444, print, and 444, [30] s. ; 21 cm
- Type:
- model:monograph, monograph, Text, vzácné tisky, and TEXT
- Subject:
- lékařství, farmacie, farmakologie, léčivé přípravky, nemoc, farmacie a farmakologie, 615, 633.88, and 61
- Language:
- Latin
- Description:
- Rejstřík, Na předním přídeští je ex libris MUDr Julia Bílka, Vazba je zhotovena z lepenky pokryté ozdobným škrobovým papírem Vazba je v zachovalém stavu, vnitřní blok je mírně opotřebovaný, Digitalizace 2017 AiP Beroun, and Restaurování 2017 Jarmila Franková
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
5. Hermanni Boerhaave De cognoscendis et curandis morbis aphorismi una cum ejusdem de materia medica et remediorum formulis libello ad singulos aphorismos digesto, ad fidem optimarum editionum recensiti et editi
- Creator:
- Boerhaave, Herman
- Publisher:
- Typis Jo. Thomae nob. de Trattnern, sac. caes. reg. aulae typographi et bibliop.
- Format:
- print and 444, [30] s. ; 21 cm
- Type:
- model:monograph, monograph, Text, vzácné tisky, and TEXT
- Subject:
- lékařství, farmacie, farmakologie, léčivé přípravky, nemoc, farmacie a farmakologie, 615, 633.88, and 61
- Language:
- Latin
- Description:
- přerušené číslování, ve zweiter Theil přeházené a zmatečné číslování, Rejstřík, Na předním přídeští je ex libris MUDr Julia Bílka, Vazba je zhotovena z lepenky pokryté ozdobným škrobovým papírem Vazba je v zachovalém stavu, vnitřní blok je mírně opotřebovaný, Digitalizace 2017 AiP Beroun, and Restaurování 2017 Jarmila Franková
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
6. Nifedipine-sensitive vascular reactivity of femoral arteries in WKY: the effects of pertussis toxin pretreatment and endothelium removal
- Creator:
- Silvia Líšková, Jaroslav Kuneš, and Josef Zicha
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, farmakologie, toxiny, endotel, pharmacology, toxins, endothelium, pertussis toxin, inhibitory G proteins, nifedipine, voltage-dependent Ca2+ channels, norepinephrine, isolated femoral artery, 14, and 612
- Language:
- English
- Description:
- Maintenance of norepinephrine (NE)-induced contraction is dependent on Ca2+ influx through L-type voltage-dependent Ca2+ channels (VDCC), which is opposed by nitric oxide. Adrenergic receptors are coupled with different G proteins, including inhibitory G proteins (Gi) that can be inactivated by pertussis toxin (PTX). Our study was aimed to investigate the effects of endothelium removal, PTX pretreatment and acute VDCC blockade by nifedipine on the contractions of femoral arteries stimulated by norepinephrine. We used 12-week-old male WKY, half of the rats being injected with PTX (10 μg/kg i.v., 48 h before the experiment), which considerably reduced their blood pressure (BP). Contractions of isolated arteries were measured using Mulvany-Halpern myograph. NE dose-response curves determined in femoral arteries from PTX-treated WKY rats were shifted to the right compared to those from control WKY. On the contrary, removal of endothelium augmented NE dose-response curves shifting them to the left. Acute VDCC blockade by nifedipine (10-7 M) abolished all differences in NE dose-response curves which were dependent on the presence of either intact endothelium or functional Gi proteins because all NE dose-response curves were identical to the curve seen in vessels with intact endothelium from PTX-treated animals. We can conclude that BP reduction after PTX injection is accompanied by the attenuation of NE-induced contraction of femoral arteries irrespective of endothelium presence. Moreover, our data indicate that both vasodilator action of endothelium and Gi-dependent vasoconstrictor effect of norepinephrine operate via the control of Ca2+ influx through VDCC., S. Líšková, J. Kuneš, J. Zicha., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
7. Nozokomiální infekce ve stáří
- Creator:
- Jedličková, Anna
- Type:
- model:article, article, Text, and TEXT
- Subject:
- infekce získané v nemocnicích--etiologie--komplikace--prevence a kontrola, staří--fyziologie, mikrobiální léková rezistence, rizikové faktory, katetrizace, infekce - kontrola, pneumonie--epidemiologie--etiologie--farmakoterapie, imunosupresiva, farmakologie, and lidé
- Language:
- Czech and English
- Description:
- Nozokomiální nákazy (NN) představují světový problém. Původci NN jsou častěji grampozitivní koky stafylokoky na jednotkách intenzivní péče chirurgických oborů, hlavně kardiochirurgie. Stafylokoky jsou původci katetrových sepsí. Dále se uplatňují jako nozokomiální kmeny bakterie z rodu Enterobacteriaceae. U starších pacientů převládají nozokomiální kmeny Escherichia coU, Klebsiella pneumoniae, Proteus mirabilis. Většina nozokomiálních kmenů je multirezistentní, proto se komplikace způsobené nozokomiálními kmeny léčí obtížně, hlavně u starších lidí pro jejich rizikové faktory, multimorbiditu, trvalou léčbu mnoha léky vč. fyziologických i patologických změn, které ovlivňují farmakoterapii i terapii ATB. Nutné je předcházet nozokomiálním nákazám nejen u starších pacientů, kde NN představuje komplikaci klinického stavu, která i při dodržení všech zásad a opatření nemusí končit uzdravením., Nosocomial diseases (ND) represent a worldwide problem. The causal agents of ND very often are gram-positive cocci - staphylococci found at intensive care units of surgical departments, mainly of cardio surgery departments. Staphylococci are causal agents of catheter sepsis. Furthermore, members of the family enterobacteriaceae also act as nosocomial strains. The most frequent forms found in the elderly patients are nosocomial strains Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis. Most of the nosocomial strains are multiresistant, therefore complications caused by nosocomial strains are treated with difficulty. mainly in elderly patients because of many high risk factors, morbidity, permanent drug treatment including physiological and pathological changes that effect pharmacotherapy as well as ATB therapy. It is necessary to avoid nosocomial diseases not only in elderly patients, for whom ND represent complications of their clinical condition from which they do not always recover even if all rules and precautions are taken., Anna Jedličková, and Lit. 11
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
8. Prof. MUDr. Dr.h.c. Helena Rašková, D.Sc. is ninety: (born January 2, 1913)
- Creator:
- Jaroslav Květina
- Format:
- print, bez média, and svazek
- Type:
- article, zprávy, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, Rašková, Helena, 1913-2010, 20.-21. století, vědkyně, farmakologie, women scientists, pharmacology, Česko, Czechia, 14, and 612
- Language:
- English
- Description:
- J. Květina, F. Perlík.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
9. Prof. RNDr. Dr.h.c. Jaroslav Květina, DrSc. Celebrates his 85th birthday
- Creator:
- Ondřej Slanař and František Perlík
- Format:
- print, bez média, and svazek
- Type:
- article, zprávy, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, Květina, Jaroslav, 1930-, farmaceuti, farmakologie, jubilejní oslavy, pharmacists, pharmacology, anniversary celebrations, 14, and 612
- Language:
- English
- Description:
- O. Slanař, F. Perlík.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
10. Structure, function, and pharmacology of NMDA receptor channels
- Creator:
- Vyklicky, V., Korinek, M., Smejkalova, T., Aleš Balík, Krausova, B., Kaniakova, M., Lichnerova, K., Cerny, J., Krusek, J., Ivan Dittert, Martin Horák, and Vyklicky, L.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, iontové kanály, farmakologie, ion channels, pharmacology, glutamate receptor, NMDA receptor, channel blocker, synaptic transmission, 14, and 612
- Language:
- English
- Description:
- NMDA receptors have received much attention over the last few decades, due to their role in many types of neural plasticity on the one hand, and their involvement in excitotoxicity on the other hand. There is great interest in developing clinically relevant NMDA receptor antagonists that would block excitotoxic NMDA receptor activation, without interfering with NMDA receptor function needed for normal synaptic transmission and plasticity. This review summarizes current understanding of the structure of NMDA receptors and the mechanisms of NMDA receptor activation and modulation, with special attention given to data describing the properties of various types of NMDA receptor inhibition. Our recent analyses point to certain neurosteroids as NMDA receptor inhibitors with desirable properties. Specifically, these compounds show use-dependent but voltage-independent block, that is predicted to preferentially target excessive tonic NMDA receptor activation. Importantly, neurosteroids are also characterized by use-independent unblock, compatible with minimal disruption of normal synaptic transmission. Thus, neurosteroids are a promising class of NMDA receptor modulators that may lead to the development of neuroprotective drugs with optimal therapeutic profiles., V. Vyklicky ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public