Metabolic syndrome is a prevalent disease resulting from an interplay of genomic component and the exposome. Parental diet has been shown to affect offspring metabolic health via multiple epigenetic mechanisms. Excess carbohydrate intake is one of the driving forces of the obesity and metabolic syndrome pandemics. This review summarizes the evidence for the effects of maternal carbohydrate (fructose, sucrose, glucose) overnutrition on the modulation of metabolic syndrome components in the offspring. Despite substantial discrepancies in experimental design, common effects of maternal carbohydrate overnutrition include increased body weight and hepatic lipid content of the "programmed" offspring. However, the administration of sucrose to several rat models leads to apparently favorable metabolic outcomes. Moreover, there is evidence for the role of genomic background in modulating the metabolic programming effect in the form of nutri-epigenomic interaction. Comprehensive, robust studies are needed to resolve the temporal, sex-specific, genetic, epigenetic and nutritional aspects of parental overnutrition in the intergenerational and transgenerational pathogenesis of metabolic syndrome.
In order to investigate the ability of infective larvae of the nematode Baylisascaris transfuga (Rudolphi, 1819) Sprent, 1968 to hatch from the egg-shells and then to migrate in tissues, parenteral infections of mice with embryonated eggs were performed. Two groups of outbred albino mice were infected with approximately 3500 B. transfuga infective eggs sub-cutaneously (SC) or intraperitoneally (IP). B. transfuga larvae in the IP group rapidly hatched and migrated to the intestine, liver, lungs, brain and carcass. Subcutaneous inoculation of eggs was followed also by migration of hatched larvae in the examined organs. In the SC mice, extensive encapsulating reactions involving the subcutaneous tissues and carcass, and containing large numbers of hatched eggs and free motile larvae, were found at the sites of inoculation. Some differences in the migratory behaviour were observed between the two groups. It is shown that B. transfuga infective larvae are able to hatch and migrate in tissues of mice, and tend to settle and/or to be trapped in the intestinal wall and muscles, even after parenteral inoculations of embryonated eggs. These results could provide basic data for further investigations on the migratory pathways of B. transfuga larvae or to perform immunological and therapeutical studies.
The article considers the issue of how the Czech legal order deals with homosexual couples and homo-parental families. The authors predominantly focus on the subject of assisted reproduction. Using the example of the legal order of United Kingdom, where the legal regulation provides the possibility to undergoassisted reproduction to nearly anybody, the authors analyse the Czech legal order and the changes introduced by the New Civil Code.
The effects of weather and individual attributes of the broods in the local population of tawny owl Strix aluco on recruitment were studied in the Duna-Ipoly National Park, Hungary (47º35’ N; 19º02’ E) in 1992–2007. In harsh breeding conditions, with many snowy days, the parents’ body condition was low and they were able to raise only few fledglings. Nevertheless, the few fledglings remaining in this reduced broods left them in better condition and had a greater chance to be recruits than offspring which fledged in mild seasons, with many siblings, from broods raised by the parents in good condition. Parents produced most male recruits in adverse breeding seasons, when one offspring fledged from the broods, but raised most female recruits in mild breeding years, when two offspring left the broods. Sex related differences in the recruitment of a local population of tawny owls are discussed with a focus on environmental effects.
To overcome the shortage of cadaveric kidneys available for transplantation, several countries organize systematic kidney exchange programs. The kidney exchange problem can be modelled as a cooperative game between incompatible patient-donor pairs whose solutions are permutations of players representing cyclic donations. We show that the problems to decide whether a given permutation is not (weakly) Pareto optimal are NP-complete.