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31662. The role of investment incentives in regional FDI reallocation: a regression-discontinuity approach
- Creator:
- Dinga, Marián, Kejak, Michal, Univerzita Karlova. Centrum pro ekonomický výzkum a doktorské studium, and Národohospodářský ústav (Akademie věd ČR)
- Publisher:
- CERGE-EI
- Format:
- electronic and 42 s.
- Type:
- model:monograph and TEXT
- Subject:
- Světová ekonomika a mezinárodní finance, zahraniční přímé investice, investiční pobídky, regionální rozvoj, 339.727.22, 35.078.5:339.727.22, 332.055.2, (048.8), 4, and 339.7/.9
- Language:
- English
- Description:
- Marián Dinga ; editor: Michal Kejak. and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31663. The role of iron in the pathogenesis of atherosclerosis
- Creator:
- Pavel Kraml
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, železo, železivce, oxidační stres, záněty, ateroskleróza, iron, ironstones, oxidative stress, inflammations, atherosclerosis, macrophages, 14, and 612
- Language:
- English
- Description:
- Ferritin and increased iron stores first appea red on the list of cardiovascular risk factors more than 30 years ago and their causal role in the pathogenesis of atherosclerosis has been heavily discussed since the early 1990s. It seems that besides traditional factors such as hyperlipoprotein emia, hyp ertension, diabetes mellitus, obesity, physical inactivity, smoking and family history, high iron stores represent an additional parameter that could modify individual cardiovascular risk. The role of iron in the pathogenesis of atherosclerosis was origina lly primarily associated with its ability to cataly ze the formation of highly reactive free oxygen radicals and the oxidation of atherogenic lipoproteins. Later, it became clear that the mechanism is more complex. Atherosclerosis is a chronic fibroprolife rative inflammatory process and iron, through increased oxidation stress as well as directly, can control both native and adaptive immune responses. Within the arterial wall, iron affects all of the cell types that participate in the atherosclerotic proces s (monocytes/macrophages, endothelial cells, vascular smooth muscle cells and platelets). Most intracellular iron is bound in ferritin, whereas redox-active iron forms labile iron pool. Pro-inflammatory and anti-inflammatory macrophages within arterial plaque differ with regard to the amount of intracellular iron and most probably with regard to their labile iron pool. Yet, the relation between plasma ferritin and intracellular labile iro n pool has not been fully clarified. Data from population studies document that the consumption of meat and lack of physical activity contribute to increased iron stores. Patients with hereditary h emochromatosis, despite extreme iron storage, do not show i ncreased manifestation of atherosclerosis probably due to the low expression of hepcidin in macrophages., P. Kraml., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31664. The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia - the risk factor or an indication of a contact with cat?
- Creator:
- Yuksel, Pelin, Alpay, Nihat, Babur, Cahit, Bayar, Reha, Saribas, Suat, Karakose, Ali Riza, Aksoy, Cana, Aslan, Mustafa, Mehmetali, Seyfi, Kilic, Selcuk, Balcioglu, Ibrahim, Hamanca, Ozlem, Dirican, Ahmet, Kucukbasmaci, Omer, Oner, Ali, Mamal Torun, Muzeyyen, and Kocazeybek, Bekir
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- schizophrenia, Toxoplasma gondii, latent toxoplasmosis, and Turkey
- Language:
- English
- Description:
- We assessed IgG antibody to Toxoplasma gondii in 300 inpatients with schizophrenia (SG), 150 outpatients with anxiety and depressive disorders (PCG), and 150 healthy blood donors (HCG). Seropositivity rates were 60.7% for SG, 36.7% for PCG, and 45.3% for HCG (p<0.001). The seropositivity rate for anti-Toxoplasma IgG antibodies in SG was significantly higher that in PCG (X2=23.11, OR=2.66, p=0.001) and HCG (X2=9.52, OR=1.86, p=0.002). Among SG, 85% of those who reported close cat contact had IgG antibodies to T. gondii. Close cat contacts were reported by 59% of SG, 6% of PCG, and 9% of HCG (p<0.001). There was a nonsignificant positive association between toxoplasmosis and schizophrenia for people with a contact with a cat (OR=2.221, p=0.127, CI95=0.796-6.192), and significant negative association between toxoplasmosis and schizophrenia for people without contact with a cat (OR=0.532, p=0.009, CI95=0.332-0.854). Close cat contact (OR=2.679, p<0.001), 51-65-year age group (OR=1.703, p<0.001) and education [illiterate+primary (OR=6.146, p<0.001) and high school (OR=1.974, p=0.023)] were detected as independent risk factors in multivariate logistic regression. The effect of toxoplasmosis on risk of schizophrenia disappeared in the complex model analyzed with multivariate logistic regression. In conclusion, our data suggest that the toxoplasmosis has no direct effect on the risk of schizophrenia in Turkey but is just an indication of previous contacts with a cat.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31665. The role of leptin in human physiology and pathophysiology
- Creator:
- Janečková, R.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, leptin, obezita, puberta, hormony, těhotenství, obesity, puberty, hormones, pregnancy, body mass index, 14, and 612
- Language:
- English
- Description:
- This review focuses on current knowledge of leptin biology and the role of leptin in various physiological and pathophysiological states. Leptin is involved in the regulation of body weight. Serum leptin can probably be considered as one of the best biological markers reflecting total body fat in both animals and humans. Obesity in man is accompanied by increased circulating leptin concentrations. Gender differences clearly exist. Leptin is not only correlated to a series of endocrine parameters such as insulin, glucocorticoids, thyroid hormones, testosterone, but it also seems to be involved in mediating some endocrine mechanisms (onset of puberty, insulin secretion) and diseases (obesity, polycystic ovary syndrome). It has also been suggested that leptin can act as a growth factor in the fetus and the neonate., R. Janečková., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31666. The role of membrane fluidity changes and thiobarbituric acid-reactive substrances production in the inhibition of cerebral cortex Na+/K+-ATPase activity
- Creator:
- Hana Rauchová, Zdeněk Drahota, and Jitka Koudelová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, cerebral cortex membranes, lipid peroxidation, membrane fluidity, 14, and 612
- Language:
- English
- Description:
- Lipid peroxidation of rat cerebral cortex membranes was induced by Fe2+/ADP and ascorbate. The rate of Na+/K+-ATPase inhibition was correlated with the increase of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes (CD) and with membrane fluidity changes. Our data showed that membrane fluidity changes (evaluated by fluorescence steady-state anisotropy measurements) can participate in Na+/K+-ATPase inhibition during the initial period of lipid peroxidation process, whereas during the following period the enzyme inhibition correlates only with TBARS and CD production., H. Rauchová, Z. Drahota, J. Koudelová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31667. The Role of Michael de Causis in the Prosecution of Jan Hus
- Creator:
- Fudge, Thomas A.
- Type:
- article, model:article, and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31668. The role of mite pocket-like structures on Agama caudospinosa (Agamidae) infested by Pterygosoma livingstonei sp. n. (Acari: Prostigmata: Pterygosomatidae)
- Creator:
- Bertrand, Michel and Modrý, David
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Pterygosomatidae, Agamidae, mite pockets, ectoparasites, and host-paraite srelationships
- Language:
- English
- Description:
- Pterygosoma livingstonei sp. n. collected from the Kenyan lizard Agama caudospinosa Meek shows morphological affinities with other South African congener species parasitizing lizards of the genus Agama, especially with P. triangulare Lawrence, 1936, but it differs in having glabrous genua II and III. P. livingstonei shows affinities with the Lawrence's hispida species group in the characters of genital and peripheral setae. This new species was found concentrated in a nuchal ''mite pocket-like structure'', a behaviour previously unreported among species belonging to the genus Pterygosoma. Mite pockets (or acarodomatia, acarinaria) of lizards typically house damaging chigger mites, and are usually interpreted as the evolutionary host's response to limit damage caused by parasites. Because scale mites are permanent ectoparasites and less damaging than seasonally occurring larval trombiculids, the heavy infestation by P. livingstonei in the nuchal skin folds of its host is interpreted as a consequence of the best utilisation of an available protected site by these mites that spend their entire life cycle on their host and whose primitive body shape prevents them from seeking shelter beneath the scales of their lizard host.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31669. The role of mitochondria in aging
- Creator:
- Kalous, M. and Drahota, Z.
- Type:
- article, model:article, and TEXT
- Subject:
- mitochondrial genome, energetic metabolism, free-oxygen radicals, and aging
- Language:
- English
- Description:
- Aging is a process drawing attention of many researchers, and at present many theories exists, which try to explain this chain of inevitable events leading to death of organism. In this article we focused our attention on a theory explaining the degenerative changes occurring during aging by the effect of oxygen free radicals. These highly reactive radicals are produced during oxidative phosphorylation in mitochondria. All cellular components appear to be sensitive to oxygen-radical damage. Lipids, proteins and nucleic acids are probably the most susceptible to this injury. Lipoperoxidation of lipids together with cross-linking of proteins with phospholipids and nucleic acids caused changes in membrane fluidity. Mitochondrial DNA coding several subunits of respiratory chain enzymes can be also damaged by these radicals. All these changes together have negative impact on mitochondrial metabolism resulting progressive decrease of the efficiency of oxidative phosphorylation and thus of the whole organism.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
31670. The role of nitric oxide in the control of cardiovascular system: introductory remarks
- Creator:
- Gérová, M.
- Type:
- article, model:article, and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public