Traditionally, lecithinxholesterol acyltransferase (LCAT) role in the reverse cholesterol transport (RCT) has been considered "antiatherogenic" as the cholesterol esterification is the prerequisite for the formation of mature high density lipoprotein (HDL) particles and may create a gradient necessary for the flow of unesterified cholesterol (UC) from tissues to plasma. However, newer data suggest that a higher esterification rate is not necessarily protective. Here we review the available data on the role of LCAT in RCT and propose that the LCAT-mediated esterification of plasma cholesterol promotes RCT only in the presence of sufficient concentrations of HDL2 while this reaction may be atherogenic in the presence of high concentration of plasma low density lipoprotein (LDL) cholesteroL Thus, the "protective" or potentially "atherogenic" role of LCAT depends on the quality of HDL and concentration of LDL. This hypothesis is consistent with the known high predictive value of LDL/HDL cholesterol ratio.
Studie Michela Dineura se zabývá vzájemnými kontakty, uskutečňovanými prostřednictvím korespondečního kontaktu mezi belgickou hudební skladatelkou Jacqueline Fontyn a českým hudebním skladatelem a muzikologem Jarmilem Burghauserem a jejich osudy od šedesátých do devadesátých let 20. století., Michel Dineur., Rubrika: Studie, and České resumé na s. 390, anglický abstrakt na s. 351.
Mild hyperhomocysteinemia has been established as a new independent risk factor for atherosclerosis and thrombosis. The metabolic syndrome of insulin resistance is associated with a high risk of coronary heart disease. Our objective was to determine if any relationship exists between the metabolic syndrome of insulin resistance in non-diabetic subjects and total serum homocysteine levels. Sixty-six healthy volunteers (33 males and 33 females) were selected from the population of Pilsen. Insulin resistance was measured by the Insulin Suppression Test using Octreotide. Steady-state plasma glucose concentrations at the end of the test period provided a quantitative measure of insulin resistance. Serum homocysteine level was estimated by high-pressure liquid chromatography. Serum folate and vitamin B12 were estimated using commercial kits on an Abbott IMx analyzer. All other laboratory tests were performed by standard methods in a routine biochemical laboratory. Subjects with the highest tertile of steady-state plasma glucose showed a significantly higher body mass index, blood pressure, fasting plasma triglyceride levels, plasminogen activator inhibitor-1 and lower HDL-cholesterol, i.e. an insulin resistance pattern. These subjects had significantly lower serum homocysteine levels compared with non-insulin resistant subjects. The negative association of insulin resistance and serum homocysteine was unexpected. The contribution of plasma folate levels to serum homocysteine levels and serum creatinine was significantly negative and positive, respectively., H. Rosolová, J. Šimon, O. Mayer Jr., J. Racek, T. Dierzé, D. W. Jacobsen., and Obsahuje bibliografii
In Abelmoschus esculentus L. uniconazole brought about a marked decrease in cadmium-induced loss of chlorophyll and Hill reaction activity, but it did not completely prevent cadmium toxicity. and S. Purohit, V. P. Singh.
Terminology for microtriches, the surface features both unique to and ubiquitous among cestodes, is standardised based on discussions that occurred at the International Workshops on Cestode Systematics in Storrs, Connecticut, USA in 2002, in České Budějovice, Czech Republic in 2005 and in Smolenice, Slovakia in 2008. The following terms were endorsed for the components of individual microtriches: The distal, electron-dense portion is the cap, the proximal more electron-lucent region is the base. These two elements are separated from one another by the baseplate. The base is composed of, among other elements, microfilaments. The cap is composed of cap tubules. The electron-lucent central portion of the base is referred to as the core. The core may be surrounded by an electron-dense tunic. The entire microthrix is bounded by a plasma membrane, the external layer of which is referred to as the glycocalyx. Two distinct sizes of microtriches are recognised: those <= 200 nm in basal width, termed filitriches, and those >200 nm in basal width, termed spinitriches. Filitriches are considered to occur in three lengths: papilliform (<= 2 times as long as wide), acicular (2-6 times as long as wide), and capilliform (>6 times as long as wide). In instances in which filitriches appear to be doubled at their base, the modifier duplicated is used. Spinitriches are much more variable in form. At present a total of 25 spinithrix shapes are recognised. These consist of 13 in which the width greatly exceeds the thickness (i.e., bifid, bifurcate, cordate, gladiate, hamulate, lanceolate, lineate, lingulate, palmate, pectinate, spathulate, trifid, and trifurcate), and 12 in which width and thickness are approximately equal (i.e., chelate, clavate, columnar, coniform, costate, cyrillionate, hastate, rostrate, scolopate, stellate, trullate, and uncinate). Spiniform microtriches can bear marginal (serrate) and/or dorsoventral (gongylate) elaborations; they can also bear apical features (aristate). The latter two modifiers should be used only if the features are present. The terminology to describe the overall form of a spinithrix should be used in the following order: tip, margins, shape. Each type of microthrix variation is defined and illustrated with one or more scanning electron micrographs. An indication of the taxa in which each of the microthrix forms is found is also provided.